Hokkaido University Research Center for Zoonosis Control

Hokkaido University Research Center for Zoonosis Control

What's New

Elucidation of regulatory mechanisms of viral ion channel protein, “viroporin”.
Division of Molecular Pathobiology, Prof. Sawa

Points of research
  • We previously demonstrated that agnoprotein of JC virus (JCV) functions as “viroporin (PLoS Pathog, 2010).
  • We demonstrate that JCV agnoprotein specifically interacts with adaptor protein complex 3 (AP-3) through its δ subunit.
  • The inhibition of the interaction between AP-3 and JCV agnoprotein suppresses JCV infection.

[Link]
Details of reseach.
Paper: Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18668-73.

2013.11.29