Elucidation of regulatory mechanisms of viral ion channel protein, “viroporin”.
Division of Molecular Pathobiology, Prof. Sawa
Points of research
- We previously demonstrated that agnoprotein of JC virus (JCV) functions as “viroporin (PLoS Pathog, 2010).
- We demonstrate that JCV agnoprotein specifically interacts with adaptor protein complex 3 (AP-3) through its δ subunit.
- The inhibition of the interaction between AP-3 and JCV agnoprotein suppresses JCV infection.
Details of reseach.
Paper: Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18668-73.