北海道大学 人獣共通感染症国際共同研究所



統括 喜田 宏

Hiroshi KIDA, D.V.M., Ph.D.

Selected Publications

A chicken influenza virus recognizes fucosylated α2,3 sialoglycan receptors on the epithelial cells lining upper respiratory tracts of chickens.
Hiono T, Okamatsu M, Nishihara S, Takase-Yoden S, Sakoda Y and Kida H.
Virology. 1982 Oct 15;122(1):38-47.
Selection of H3 avian influenza viruses with SAα2,6Gal receptor specificity in pigs.
Shichinohe S, Okamatsu M, Sakoda Y and Kida H.
Virology. 2013 Sep;444(1-2):404-8.
Characterization of H5N1 highly pathogenic avian influenza virus strains isolated from migratory waterfowl in Mongolia on the way back from the southern Asia to their northern territory.
Sakoda Y, Sugar S, Batchluun D, Erdene-Ochir TO, Okamatsu M, Isoda N, Soda K, Takakuwa H, Tsuda Y, Yamamoto N, Kishida N, Matsuno K, Nakayama E, Kajihara M, Yokoyama A, Takada A, Sodnomdarjaa R and Kida H.
Virology. 2010 Oct 10;406(1):88-94.
Avirulent Avian influenza virus as a vaccine strain against a potential human pandemic.
Takada A, Kuboki N, Okazaki K, Ninomiya A, Tanaka H, Ozaki H, Itamura S, Nishimura H, Enami M, Tashiro M, Shortridge KF and Kida H.
J Virol. 1999 Oct;73(10):8303-7.
Potential for transmission of avian influenza viruses to pigs.
Kida H, Ito T, Yasuda J, Shimizu Y, Itakura C, Shortridge KF, Kawaoka Y and Webster RG.
J Gen Virol. 1994 Sep;75 ( Pt 9):2183-8.
Molecular evidence for a role of domestic ducks in the introduction of avian H3 influenza viruses to pigs in southern China, where the A/Hong Kong/68 (H3N2) strain emerged.
Yasuda J, Shortridge KF, Shimizu Y and Kida H.
J Gen Virol. 1991 Aug;72 ( Pt 8):2007-10.
Origin of the hemagglutinin gene of H3N2 influenza viruses from pigs in China.
Kida H, Shortridge KF and Webster RG.
Virology. 1988 Jan;162(1):160-6.
Antigenic and genetic conservation of H3 influenza virus in wild ducks.
Kida H, Kawaoka Y, Naeve CW and Webster RG.
Virology. 1987 Jul;159(1):109-19.
Biological activity of monoclonal antibodies to operationally defined antigenic regions on the hemagglutinin molecule of A/Seal/Massachusetts/1/80 (H7N7) influenza virus.
Kida H, Brown LE and Webster RG.
Virology. 1982 Oct 15;122(1):38-47.

准教授 新開 大史

Masashi SHINGAI, D.V.M., Ph.D.

Selected Publications

Potent priming by inactivated whole influenza virus particle vaccines is linked to viral RNA uptake into antigen presenting cells
Shingai M, Nomura N, Sekiya T, Ohno M, Fujikura D, Handabile C, Omori R, Ohara Y, Nishimura T, Endo M, Kimachi K, Mitsumata R, Ikeda T, Kitayama H, Hatanaka H, Sobue T, Muro F, Suzuki S, Thanh Nguyen C, Ishigaki H, Nakayama M, Mori Y, Itoh Y, Koutsakos M, Chua BY, Kedzierska K, Brown LE, Jackson DC, Ogasawara K, Kino Y, Kida H.
Vaccine. 2021 Jun 2:S0264-410X(21)00660-5.
The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells.
Shingai M, Welbourn S, Brenchley JM, Acharya P, Miyagi E, Plishka RJ, Buckler-White A, Kwong PD, Nishimura Y, Strebel K, Martin MA.
PLoS Pathog. 2015 May 21;11(5):e1004928.
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques.
Shingai M, Donau OK, Plishka RJ, Buckler-White A, Mascola JR, Nabel GJ, Nason MC, Montefiori D, Moldt B, Poignard P, Diskin R, Bjorkman PJ, Eckhaus MA, Klein F, Mouquet H, Cetrulo Lorenzi JC, Gazumyan A, Burton DR, Nussenzweig MC, Martin MA, Nishimura Y.
J Exp Med. 2014 Sep 22;211(10):2061-74.
Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia.
Shingai M, Nishimura Y, Klein F, Mouquet H, Donau OK, Plishka R, Buckler-White A, Seaman M, Piatak M Jr, Lifson JD, Dimitrov DS, Nussenzweig MC, Martin MA.
Nature. 2013 Nov 14;503(7475):277-80.
Most rhesus macaques infected with the CCR5-tropic SHIV(AD8) generate cross-reactive antibodies that neutralize multiple HIV-1 strains.
Shingai M, Donau OK, Schmidt SD, Gautam R, Plishka RJ, Buckler-White A, Sadjadpour R, Lee WR, LaBranche CC, Montefiori DC, Mascola JR, Nishimura Y, Martin MA.
Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19769-74.
Some human immunodeficiency virus type 1 Vpu proteins are able to antagonize macaque BST-2 in vitro and in vivo: Vpu-negative simian-human immunodeficiency viruses are attenuated in vivo.
Shingai M, Yoshida T, Martin MA, Strebel K.
J Virol. 2011 Oct;85(19):9708-15.
Differential type I IFN-inducing abilities of wild-type versus vaccine strains of measles virus.
Shingai M, Ebihara T, Begum NA, Kato A, Honma T, Matsumoto K, Saito H, Ogura H, Matsumoto M, Seya T.
J Immunol. 2007 Nov 1;179(9):6123-33.
Wild-type measles virus infection in human CD46/CD150-transgenic mice: CD11c-positive dendritic cells establish systemic viral infection.
Shingai M, Inoue N, Okuno T, Okabe M, Akazawa T, Miyamoto Y, Ayata M, Honda K, Kurita-Taniguchi M, Matsumoto M, Ogura H, Taniguchi T, Seya T.
J Immunol. 2005 Sep 1;175(5):3252-61.

助教 関屋 俊輝

Toshiki SEKIYA, Ph.D.

Selected Publications

Selecting and Using the Appropriate Influenza Vaccine for Each Individual
Sekiya T, Ohno M, Nomura N, Handabile C, Shingai M, Jackson DC, Brown LE, Kida H.
Viruses. 2021 May 24;13(6):971.
Immune profiling of influenza-specific B- and T-cell responses in macaques using flow cytometry-based assays
Koutsakos M, Sekiya T, Chua BY, Nguyen THO, Wheatley AK, Juno JA, Ohno M, Nomura N, Ohara Y, Nishimura T, Endo M, Suzuki S, Ishigaki H, Nakayama M, Nguyen CT, Itoh Y, Shingai M, Ogasawara K, Kino Y, Kent SJ, Jackson DC, Brown LE, Kida H, Kedzierska K.
Immunol Cell Biol. 2021 Jan;99(1):97-106.
Inactivated whole virus particle vaccine with potent immunogenicity and limited IL-6 induction is ideal for influenza.
Sekiya T, Mifsud EJ, Ohno M, Nomura N, Sasada M, Fujikura D, Daito T, Shingai M, Ohara Y, Nishimura T, Endo M, Mitsumata R, Ikeda T, Hatanaka H, Kitayama H, Motokawa K, Sobue T, Suzuki S, Itoh Y, Brown LE, Ogasawara K, Kino Y, Kida H.
Vaccine. 2019 Apr 3;37(15):2158-2166.
Opinion: Making Inactivated and Subunit-Based Vaccines Work.
Chua BY, Sekiya T, Jackson DC.
Viral Immunol. 2018 Mar;31(2):150-158.
PEGylation of a TLR2-agonist-based vaccine delivery system improves antigen trafficking and the magnitude of ensuing antibody and CD8+ T cell responses.
Sekiya T, Yamagishi J, Gray JHV, Whitney PG, Martinelli A, Zeng W, Wong CY, Sugimoto C, Jackson DC, Chua BY.
Biomaterials. 2017 Aug;137:61-72.
A single dose biodegradable vaccine depot that induces persistently high levels of antibody over a year.
Chua BY, Sekiya T, Al Kobaisi M, Short KR, Mainwaring DE, Jackson DC.
Biomaterials. 2015 Jun;53:50-7.

助教 大野 円実

Marumi OHNO, D.V.M., Ph.D.

Selected Publications

Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2
Ohno M, Sasaki M, Orba Y, Sekiya T, Masum MA, Ichii O, Sawamura T, Kakino A, Suzuki Y, Kida H, Sawa H, Shingai M.
Viruses. 2021 Oct 22;13(11):2137.
Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model
Ohno M, Kakino A, Sekiya T, Nomura N, Shingai M, Sawamura T, Kida H.
Sci Rep. 2021 Aug 3;11(1):15675.
Influenza virus infection affects insulin signaling, fatty acid-metabolizing enzyme expressions, and the tricarboxylic acid cycle in mice
Ohno M, Sekiya T, Nomura N, Daito TJ, Shingai M, Kida H.
Sci Rep. 2020 Jul 2;10(1):10879.
GR Utilizes a Co-Chaperone Cytoplasmic CAR Retention Protein to Form an N/C Interaction.
Ohno M, Negishi M.
Nucl Recept Signal. 2018 Oct 24;15:1550762918801072.
Co-Chaperone-Mediated Suppression of LPS-Induced Cardiac Toxicity Through NFκB Signaling.
Ohno M, Moore R, Myers P, Negishi M.
Shock. 2018 Aug;50(2):248-254.
The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers.
Ohno M, Kanayama T, Moore R, Ray M, Negishi M.
PLoS One. 2014 Dec 26;9(12):e115663.
Sudan III dye strongly induces CYP1A1 mRNA expression in HepG2 cells.
Ohno M, Ikenaka Y, Ishizuka M.
J Biochem Mol Toxicol. 2012 Jan;26(1):16-22.
All-trans retinoic acid inhibits the recruitment of ARNT to DNA, resulting in the decrease of CYP1A1 mRNA expression in HepG2 cells.
Ohno M, Ikenaka Y, Ishizuka M.
Biochem Biophys Res Commun. 2012 Jan 6;417(1):484-9.

特任助教 野村 直樹

Naoki NOMURA , Ph.D.

Selected Publications

Updating the influenza virus library at Hokkaido University -It's potential for the use of pandemic vaccine strain candidates and diagnosis
Nomura N, Matsuno K, Shingai M, Ohno M, Sekiya T, Omori R, Sakoda Y, Webster RG, Kida H.
Virology. 2021 May;557:55-61.
The genetic and antigenic diversity of avian influenza viruses isolated from domestic ducks, muscovy ducks, and chickens in northern and southern Vietnam, 2010-2012.
Okamatsu M, Nishi T, Nomura N, Yamamoto N, Sakoda Y, Sakurai K, Chu HD, Thanh LP, Van Nguyen L, Van Hoang N, Tien TN, Yoshida R, Takada A, Kida H.
Virus Genes. 2013 Oct;47(2):317-29.
An H9N2 influenza virus vaccine prepared from a non-pathogenic isolate from a migratory duck confers protective immunity in mice against challenge with an H9N2 virus isolated from a girl in Hong Kong.
Nomura N, Sakoda Y, Soda K, Okamatsu M, Kida H.
J Vet Med Sci. 2012 Apr;74(4):441-7.
Characterization of avian influenza viruses isolated from domestic ducks in Vietnam in 2009 and 2010.
Nomura N, Sakoda Y, Endo M, Yoshida H, Yamamoto N, Okamatsu M, Sakurai K, Hoang NV, Nguyen LV, Chu HD, Tien TN, Kida H.
Arch Virol. 2012 Feb;157(2):247-57.
A vaccine prepared from a non-pathogenic H5N1 influenza virus strain from the influenza virus library conferred protective immunity to chickens against the challenge with antigenically drifted highly pathogenic avian influenza virus.
Samad RA, Nomura N, Tsuda Y, Manzoor R, Kajihara M, Tomabechi D, Sasaki T, Kokumai N, Ohgitani T, Okamatsu M, Takada A, Sakoda Y, Kida H.
Jpn J Vet Res. 2011 Feb;59(1):23-9.

大学院生 Chimuka HANDABILE

技術補佐員 川原 麻弥子

Mamiko Kawahara

事務補佐員 木村 奈緒美

Naomi Kimura