Publications

2022: 9 publications

Total Publications: 9

Original articles: 9, Review articles/Book: o, Granted patents: 0, Applied patents: 0

 *Corresponding author, ** Equal contribution, Faculty members are underlined. 

Original articles with review

  1. Kim H*, Mori S, Kenri T, Suzuki Y. Molecular characterization of Mycobacterium ulcerans DNA gyrase and identification of mutations reduced susceptibility against quinolones in vitro. Antimicrob Agents Chemother, in press.

  2. Usui M*, Fukuda A, Suzuki Y, Nakajima C, Tamura Y. Broad-host-range IncW plasmid harbouring tet(X) in Escherichia coli isolated from pigs in Japan. J Glob Antimicrob Resist; in press, doi: 10.1016/j.jgar.2021.12.012.

  3. Usui M*, Tase J, Onozaki M, Suzuki Y, Tamura Y, Nakajima C. Campylobacter Express Resistance Array for detecting the presence of fluoroquinolone- and macrolide-resistant Campylobacter jejuni and Campylobacter coli in broiler farms. J Appl Microbiol, in press, doi: 10.1111/jam.15390

  4. Watari K, Konnai S*, Okagawa T, Maekawa N, Sajiki Y, Kato Y, Suzuki Y, Murata S, Ohashi K. Enhancement of IL-2 production by bovine peripheral blood mononuclear cells treated with the combination of anti-PD-L1 and CTLA-4 chimeric monoclonal antibodies. J Vet Med Sci, in press, doi: 10.1292/jvms.21-0552.

  5. Arimura Y, Minato Y, Wada T, Nakayama M, Ryumon A, Hirata N, Nakajima C, Suzuki Y, Ato M, Kobayashi K, Ohara N, Iida S, Ohara N*. Attempt of thyX gene silencing and construction of a thyX deleted clone in a Mycobacterium bovis BCG. Microb Immunol 2021, doi: 10.1111/1348-0421.12944.

  6. Kapalamula TF, Chizimu J, Belotindos L, Akapelwa M, Shrestha D, Nyenje ME, Munyeme M, Hang’ombe BM, Mkakosya RS, Gordon SV, Nakajima C, Suzuki Y*. Molecular epidemiology of Mycobacterium bovis in central parts of Malawi. Transbound Emerg Dis 2021, doi: 10.1111/tbed.14127.

  7. Squarre D, Chizimu J, Nakajima C, Muma JB, Hang’ombe BM, Simulundu E, Mwasinga WW, Katampi J, Fandamu P, Suzuki Y, Sawa H, Munang’andu HM, Shanungu G, Chambaro HM, Munyeme M*. First report of Mycobacterium bovis in wild chacma baboons (Papio ursinus) at the human-wildlife interface area in Zambia. Transbound Emerg Dis 2021, doi: 10.1111/tbed.14124.

  8. Chizimu JY, Solo ES, Bwalya P, Tanomsridachchai W, Chambaro H, Shawa M, Kapalamula TF, Lungu P, Fukushima Y, Mukonka V, Thapa J, Nakajima C*, Suzuki Y*. Whole-genome sequencing reveals recent transmission of multidrug-resistant Mycobacterium tuberculosis CAS1-Kili strains in Lusaka, Zambia. Antibiotics 2022 Jan:11(1):29. doi: 10.3390/antibiotics11010029

  9. Chizimu JY, Solo ES, Bwalya P, Kapalamula TF, Akapelwa LM, Lungu P, Shrestha D, Fukushima Y, Mukonka V, Thapa J, Nakajima C*, Suzuki Y*. Genetic Diversity and Transmission of Multidrug Resistant Mycobacterium tuberculosis strains in Lusaka, Zambia. Int J Infect Dis 2022 Jan:114:142-150. doi: 10.1016/j.ijid.2021.10.044.


2021: 32 publications

Total Publications: 32

Original articles: 30, Review articles/Book: 1, Granted patents: 0, Applied patents: 1

 *Corresponding author, ** Equal contribution, Faculty members are underlined. 

Original articles with review

  1. Park J-H, Yamaguchi T, Ouchi Y, Koide K, Pachanon R, Chizimu JY, Mori S, Kim H, Mukai T, Nakajima C, Suzuki Y*. Interaction of quinolones carrying new R1 group with Mycobacterium leprae DNA gyrase. Microb Drug Resist 2021 Dec, 27(12):1616-1623. doi: 10.1089/mdr.2020.0408.

  2. Chonsin K, Changkwanyeun R, Siriphap A, Intarapuk A, Prapasawat W, Changkaew K, Pulsrikan C, Isoda N, Nakajima C, Suzuki Y*, Suthienkul O*. Prevalence and Multidrug-Resistance Salmonella in Swine Production Chain in a Central Province, Thailand. J Food Protect 2021 Dec, 84(12):2174-2184, doi: 10.4315/JFP-21-003.

  3. Ganbaatar O, Konnai S*, Okagawa T, Nojima Y, Maekawa N, Ichikawa Y, Kobayashi A, Shibahara T, Yanagawa Y, Higuchi H, Kato Y, Suzuki Y, Murata S, Ohashi K. Programmed death-ligand 1 expression in swine chronic infections and enhancement of interleukin-2 production via programmed death-1/programmed death-ligand 1 blockade. Immun Inflamm Dis 2021 Dec, 9(4):1573-1583, doi: 10.1002/iid3.510.

  4. Maharjan B*, Thapa J, Shah DK, Shrestha B, Avsar K, Suzuki Y, Nakajima C. Evaluation of Xpert MTB/RIF with microscopy and culture for the diagnosis of tuberculosis in a referral laboratory in Nepal. Jpn J Infect Die 2021 Nov, 74(6):517-521., doi: 10.7883/yoken.JJID.2020.921.

  5. Ohno M, Sasaki M, Orba Y, Sekiya T, Md. Masum MA, Ichii O, Sawamura T, Kakino A, Suzuki Y, Kida H, Sawa H*, Shingai M*. Abnormal blood coagulation and kidney damage in aged hamsters infected with severe acute respiratory syndrome coronavirus 2. Viruses 2021 Oct:13(11):2137. doi: 10.3390/v13112137.

  6. Pachanon R, Koide K, Kongsoi S, Ajima N, Kapalamula TF, Nakajima C, Suthienkul O*, Suzuki Y*. Effectiveness of fluoroquinolones with difluoropyridine derivatives as R1 groups on the Salmonella DNA gyrase in the presence and absence of plasmid-encoded quinolone resistance protein QnrB19. Microb Drug Resist 2021 Oct;27(10):1412-1419, doi: 10.1089/mdr.2020.0455.

  7. Koide K, Lai Lai San, Pachanon R, Park J-H, Ouchi Y, Kongsoi S, Utrarachkij F, Nakajima C, Suzuki Y*. Amino acid substitution Ser83Ile in GyrA of DNA gyrases confers high-level quinolone resistance to nontyphoidal Salmonella without loss of supercoiling activity. Microb Drug Resist 2021 Oct;27(10):1397-1404. doi: 10.1089/mdr.2020.0437.

  8. Fukushima Y, Sato T*, Tsukamoto N, Nakajima C, Suzuki Y, Takahashi S, Yokota S-I. Clonal/subclonal changes and accumulation of CTX-M-type β-lactamase genes in fluoroquinolone-resistant Escherichia coli ST131 and ST1193 strains isolated during the past 12 years, Japan. J Glob Antimicrob Resist 2021 Sep, 27:150-155. doi: 10.1016/j.jgar.2021.08.015.

  9. Katada S, Fukuda A, Nakajima C, Suzuki Y, Azuma T, Takei A, Takada H, Okamoto E, Kato T, Tamura Y, Usui M*. Aerobic composting and anaerobic digestion decrease the levels of antimicrobial resistance in Japanese dairy farms. Front Microbiol 2021 Sep, 12:737420. doi: 10.3389/fmicb.2021.737420.

  10. Bwalya P, Yamaguchi T, Solo ES, Chizimu JY, Mbulo G, Nakajima C*, Suzuki Y*. Characterization of mutations associated with streptomycin resistance in multidrug resistant Mycobacterium tuberculosis in Zambia. Antibiotics 2021 Sep 26, 10(10): 1169, doi: 10.3390/antibiotics10101169

  11. Paudel S, Brenner EP, Hadi SA, Suzuki Y, Nakajima C, Tsubota T, Gairhed KP, Maharjan B, Sreevatsan S. Genome Sequences of two Mycobacterium tuberculosis Isolates from Asian Elephants of Nepal. Microb Resour Announc 2021 Sep 9;10(36):e0061421. doi: 10.1128/MRA.00614-21.

  12. Guan Q, Garbati M, Mfarrej S, AlMutairi T, Laval T, Singh A, Fagbo S, Smyth A, Browne JA, urRahman MA, Alruwaili A, Hoosen A, Meehan CJ, Nakajima C, Suzuki Y, Demangel C, Bhatt A, Gordon SV, AlAsmari F, Pain A. Insights into the ancestry evolution of the Mycobacterium tuberculosis complex from analysis of Mycobacterium riyadhense. NAR Genom Bioinform 2021 Aug 11, 3(3): lqab070, https://doi.org/10.1093/nargab/lqab070.

  13. Thapa J*, Mikota SK, Gairhe KP, Paudel S, Singh DK, Dhakal IP, Nakajima C, Suzuki Y. Tuberculosis seroprevalence and comparison of hematology and biochemistry parameters between seropositive and seronegative captive Asian elephants of Nepal. J Vet Med Sci 2021 Aug, 83(3): 1278-1283, doi: 10.1292/jvms.21-0113.

  14. Akapelwa ML, Kapalamula TF, Ouchi-Aizu Y, Hang’ombe BM, Nishiuchi Y, Gordon SV, Solo ES, Tamaru A, Nishimura T, Hasegawa N, Morimoto K, Fukushima Y, Suzuki Y*, Nakajima C*. Evaluation of IS1245 LAMP in Mycobacterium avium and the influence of host-related genetic diversity on its application. Diagn Microbiol Infect Dis 2021 Jul, 101(4): 115494, doi: 10.1016/j.diagmicrobio.2021.115494.

  15. Sato T*, Usui M, Harada K, Fukushima Y, Nakajima C, Suzuki Y, Yokota S-I. Complete genome sequence of a mcr-10-possessing Enterobacater roggenkampii isolated from a dog in Japan. Microb Resour Announc 2021 Jul, 10(30):e0042621. doi: 10.1128/MRA.00426-21.

  16. Sato T*, Usui M, Harada K, Fukushima Y, Nakajima C, Suzuki Y, Yokota S-I. Complete genome sequence of a mcr-9 possessing Enterobacater asburiae isolated from a cat in Japan. Microb Resour Announc 2021 Jul, 10(26):e0028121. doi: 10.1128/MRA.00281-21.

  17. Takeuchi H, Konnai S*, Maekawa N, Takagi S, Ohta H, Sasaki N, Kim S, Okagawa T, Suzuki Y, Murata S, Ohashi K.  Canine transforming growth factor-β receptor 2-Ig: a promising candidate biologic for cancer treatment that reverses transforming growth factor-β1 immunosuppression. Front Vet Sci 2021 June 14, 8, 656715, doi: 10.3389/fvets.2021.656715.

  18. Ilinov A, Nishiyama A, Namba H, Fukushima Y, Takihara H, Nakajima C, Savitskaya A, Kaboso SA, Vinnik YS, Gebretsadik G, Hakamata M, Ozeki Y, Tateishi Y, Okuda S, Suzuki Y, Matsumot S*. Extracellular DNAs of slow growers of mycobacteria and its contribution to biofilm formation and drug tolerance. Sci Rep 2021 May 26;11(1):10953, doi: 10.1038/s41598-021-90156-z.

  19. Kodera T, Yamaguchi T, Fukushima Y, Kobayashi K, Takarada Y, Chizimu JY, Nakajima C, Solo E, Lungu P, Kawase M, Suzuki Y*. Rapid and simple detection of isoniazid resistant Mycobacterium tuberculosis utilizing DNA chromatography based technique. Jpn J Infect Dis 2021 May, 74(3), 214-219, doi: 7883/yoken.JJID.2020.754.

  20. Usui M, Tateno S, Onozaki M, Misawa N, Suzuki Y, Tamura Y, Nakajima C*. Rapid and Simultaneous Detection of Fluoroquinolone- and Macrolide-resistant Campylobacter jejuni/coli in Retail Chicken Meat using CAMpylobacter Express Resistance Array (CAMERA). Food Control 2021 May, 123, 107815, doi: 10.1016/j.foodcont.2020.107815.

  21. Tsunoda R, Usui M, Tagaki C, Fukuda A, Boonla C, Anomasiri W, Sukpanyatham N, Akapelwa ML, Nakajima C, Tamura Y, Suzuki Y*. Genetic characterization of coliform bacterial isolates from environmental water in Thailand. J Infect Chemother 2021 May, 27(5):722-728, doi: 10.1016/j.jiac.2020.12.023.

  22. Tateishi Y*, Ozeki Y, Nishiyama A, Miki M, Maekura R, Fukushima Y, Nakajima C, Suzuki Y, Matsumoto S. Comparative genomic analysis of M. intracellulare reveals the new phylogeny and genetic components of genomic diversity among clinical strains from pulmonary MAC disease. BMC Microbiol 2021 Apr 6;21(1):103. doi: 10.1186/s12866-021-02163-9.

  23. Belotindos L, Villanueva M, Miguel J, Bwalya P, Harada T, Kawahara R, Nakajima C, Mingala C, Suzuki Y*. Prevalence and Characterization of Quinolone Resistance Determinants in Escherichia coli Isolated from Food-producing Animals and Food Products in the Philippines. Antibiotics 2021 April, 10, 413. https://doi.org/10.3390/antibiotics10040413.

  24. Sajiki Y, Konnai S*, Nagata R, Kawaji S, Nakamura H, Fujisawa S, Okagawa T, Maekawa N, Kato Y, Suzuki Y, Murata S, Mori Y, Ohashi K. The enhancement of Th1 immune response by anti-PD-L1 antibody in cattle infected with Mycobacterium avium subsp. paratuberculosis. J Vet Med Sci 2021 Feb, 83(2):162-166, doi: 10.1292/jvms.20-0590.

  25. Tanomsridachchai W, Changkwanyeun R, Chankaew K, Prapasawat W, Intarapuk A, Fukushima Y, Yamasamit N, Kapalamula TF, Nakajima C, Suthienkul O*, Suzuki Y*. Antimicrobial resistance and molecular characterization of methicillin-resistant Staphylococcus aureus isolated from slaughtered pigs and pork in central region, Thailand. Antibiotics 2021 Feb, 10: 206, doi:10.3390/antibiotics10020206.

  26. Maekawa N, Konnai S*, Nishimura M, Kagawa Y, Takagi S, Okagawa T, Nishimori A, Ikebuchi R, Izumi Y, Deguchi T, Nakajima C, Yamada S, Kato Y, Yamamoto K, Uemura H, Suzuki Y, Murata S, Ohashi K. PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma. npj Precis Oncol 2021 Feb;5(1):10. doi: 10.1038/s41698-021-00147-6.

  27. Chonsin K, Supha N, Nakajima C, Suzuki Y, Suthienkul O*. Characterization of Vibrio parahaemolyticus strains isolated from clinically asymptomatic seafood workers. FEMS Microbiol Lett 2021 Jan;68;fnaa209. doi: 10.1093/femsle/fnaa209.

  28. Kapalamula TF, Thapa J, Akapelwa ML, Hayashida K, Gordon S, Hang`ombe B, Munyeme M, Solo ES, Bwalya P, Tamaru A, Suzuki YNakajima C*. Development of a loop-mediated isothermal amplification (LAMP) method for specific detection of Mycobacterium bovis. PLOS Neglect Trop Dis 2021 Jan;15(1):e0008996. doi: 10.1371/journal.pntd.0008996.

  29. Solo ES, Suzuki Y**, Kaile T, Bwalya P, Lungu P, Chizimu JY, Shah Y, Nakajima C*. Characterization of Mycobacterium tuberculosis genotypes and their correlation to multidrug resistance in Lusaka, Zambia. Int J Infect Dis 2021 Jan;102:489-496, doi: 10.1016/j.ijid.2020.10.014.

  30. Sajiki Y, Konnai S*, Okagawa T, Maekawa N, Kato Y, Suzuki Y, Murata S, Ohashi K. Immune activation and enhanced efficacy of programmed death-ligand 1 blockade by Toll-like receptor 7 agonist via CD11c+ cells in bovine leukemia virus infection. A TLR7 agonist activates bovine Th1 response and exerts antiviral activity against bovine leukemia virus. Dev Comp Immunol 2021 Jan;114(1):103847, doi:10.1016/j.dci.2020.103847.


Review articles/Book: 1

  1. 後藤正道, 鈴木定彦. ハンセン病研究と日米医学協力計画. 日本ハンセン病学会誌 2021, 印刷中


Applied patents: 1

  1. Suzuki Y, Nakagawa M, Kameda Y, Konnai S, Okagawa T, Maekawa N, Goto S, Sajiki Y, Ohashi K, Murata S, Kitahara Y, Yamamoto K. National University Cooperation Hokkaido University, Fuso Pharmaceutical Industries, Ltd. Novel vector and use thereof. Hong Kong Application No. 62021036390, 2021 August 9.


2020: 30 publications

Total Publications: 37

Original articles: 22, Review articles/Book: 1, Granted patents: 1, Applied patents: 6

 *Corresponding author, ** Equal contribution, Faculty members are underlined. 

Original articles with review

  1. Sato T*, Wada T, Nishijima S, Fukushima Y, Nakajima C, Suzuki Y, Takahashi S, and Yokota S-I. Emergence of the novel aminoglycoside acetyltransferase variant aac(6')-Ib-D179Y and an elevated rate of colistin resistance in carbapenem-resistant Klebsiella pneumoniae due to a disrupting mutation in the DNA repair enzyme MutS. mBio 2020 Dec 22, 11(6):e01954-20, doi: 10.1128/mBio.01954-20. 

  2. Sajiki Y, Konnai S*, Cai Z, Takada K, Okagawa T, Maekawa N, Fujisawa S, Kato Y, Suzuki Y, Murata S, Ohashi K. Enhanced immunotherapeutic efficacy of anti-PD-L1 antibody by combination with EP4 antagonist. ImmunoHorizon, 4(12):837-850, doi: 10.4049/immunohorizons.2000089.

  3. Rudeeaneksin J, Phetsuksiri B, Nakajima C, Bunchoo S , Suthum K, Tipkrua N, Fukushima Y, Suzuki Y*. Drug-resistant Mycobacterium tuberculosis and its genotypes isolated from an outbreak in western Thailand. Trans R Soci Trop Med Hyg, 2020 Dec 15;traa148.doi: 10.1093/trstmh/traa148. 

  4. Hiyamaa Y, Sato T*, Takahashi S, Yamamoto S, Fukushima Y, Nakajima C, Suzuki Y, Yokota S, MasumoriN. Sitafloxacin has a potent activity for eradication of extended spectrum β-lactamase-producing fluoroquinolone-resistant Escherichia coli forming intracellular bacterial communities in uroepithelial cells. J Infect Chemother, 2020 Dec;26(12):1272-1277. doi: 10.1016/j.jiac.2020.07.009 

  5. Shrestha D, Maharjan B, Nan Aye Thida Oo, Isoda N, Nakajima C, Suzuki Y*. Molecular analysis of streptomycin-resistance associating genes in Mycobacterium tuberculosis isolates from Nepal. Tuberculosis, 2020 Dec;125(12):101985. doi: 10.1016/j.tube.2020.101985. 

  6. Pachanon R, Koide K, Kongsoi S, Nakajima C, Kapalamula TF, Suthienkul O, Suzuki Y*. Interaction of the plasmid-encoded quinolone resistance protein QnrB19 with Salmonella Typhimurium DNA gyrase. J Infect Chemother, 2020 Nov;26(11): 26(11):1139-1145. doi: 10.1016/j.jiac.2020.06.002. 

  7. Ganbaatar O, Konnai S, Okagawa T, Nojima Y, Maekawa N, Minato E, Kobayashi A, Ando R, Sasaki N, Miyakosi D, Ichi O, Kato Y, Suzuki Y, Murata S, Ohashi K. PD-L1 expression in equine malignant melanoma and functional effects of PD-L1 blockade. PLOS ONE, 2020 Nov;15(11):e0234218. doi:10.1371/journal.pone.0234218. 

  8. Takarada Y, Kodera T, Kobayashi K, Nakajima C, Kawase M, Suzuki Y*. Rapid detection of rifampicin-resistant Mycobacterium tuberculosis based on isothermal DNA amplification. J Microbiol Methods, 177(2020):106062. DOI: 10.1016/j.mimet.2020.106062. 

  9. Terasawa Y, Sataka C, Nakajima C, Sato T, Yamamoto K, Fukushima Y, Suzuki Y, Katsuyama A, Matsumaru T, Yakushiji F, Yokota S-I, Ichikawa S*. Elucidating Structural Requirement of Uridylpeptide Antibiotics on Antibacterial Activity. J Med Chem, 63(17):9803-9827. doi: 10.1021/acs.jmedchem.0c00973.

  10. Solo ES, Nakajima C, Kaile T, Bwalya P, Grace Mbulo G, Fukushima Y, Chila S, Kapata N, Shah Y, Suzuki Y*. Mutations of rpoBkatGand inhA genes in multidrug-resistant Mycobacterium tuberculosis isolates from Zambia. J Glob Antimicrob Resist 2020 Sep;22(2020):302-307. doi: 10.1016/j.jgar.2020.02.026. 

  11. Phetsuksiri B*, Rudeeaneksin J, Srisungngam S, Bunchoo S, Klayut W, Nakajima C, Hamada S, and Suzuki Y. Comparison of Loop-Mediated Isothermal Amplification, Microscopy, Culture, and PCR for Diagnosis of Pulmonary Tuberculosis. Jpn J Infect Dis 2020 Jul;73(4):272-277. doi: 10.7883/yoken.JJID.2019.335. 

  12. Ohkoshi Y, Sato T, Murabayashi H, Sakai K, Takakuwa Y, Fukushima Y, Nakajima CSuzuki Y, Yokota S-I*. Campylobacter upsaliensisisolated from a giant hepatic cyst. J Infect Chemother, 2020 Jul;26(7):752-755. doi: 10.1016/j.jiac.2020.02.015. 

  13. Phetsuksiri B*, Klayut W, Rudeeaneksin J, Srisungngam S, Bunchoo S, Toonkomdang S, Wongchai T, Nakajima CSuzuki Y. The performance of in-house loop-mediated isothermal amplification for rapid detection of Mycobacterium tuberculosis in sputum samples comparing to Xpert MTB/RIF, microscopy and culture. Rev Inst Med Trop São Paulo 2020 Jun 5;62:e36, doi: 10.1590/S1678-9946202062036. 

  14. Sato T*, Wada T, Shinagawa M, Fukushima Y, Nakajima CSuzuki Y, Takahashi S, Yokota S-I. Emergence of vancomycin and teicoplanin-resistant Enterococcus faeciumvia vanD5-harbouring large genomic island. J Antimicrob Chemother, 2020 Jun 25;57(7):e01992-18, doi:10.1093/jac/dkaa220. 

  15. Oe C, Hayashi H, Hirata K, Kawaji K, Hashima F, Sasano M, Furuichi M, Usui E, Katsumi M, Suzuki YNakajima C, Kaku M, Kodama E*. Pyrimidine Analogues as a New Class of Gram-Positive Antibiotics, Mainly Targeting Thymineless-Death Related Proteins. ACS Infect Dis, 2020 Jun 12;6(6):1490-1500. doi: 10.1021/acsinfecdis.9b00305.

  16. Goto S, Konnai S, Hirano Y, Kohara J, Okagawa T, Maekawa N, Sajiki Y, Watari K, Minato E, Kobayashi A, Gondaira S, Higuchi H, Koiwa M, Tajima M, Taguchi E, Ishida M, Uemura R, Yamada S, Kaneko M, Kato Y, Yamamoto K, Toda M, Suzuki Y, Murata S, Ohashi K. Clinical efficacy of the combined treatment of anti-PD-L1 rat-bovine chimeric antibody with a COX-2 inhibitor in calves infected with Mycoplasma bovis. Jpn J Vet Res, 2020 May;68(2):77-90. 

  17. Suzuki Y, Sato T, Fukushima Y, Nakajima C, Shinagawa M, Suzuki Y, Takahashi S, Yokota S-I*. Contribution of β-Lactamase and Efflux Pump Overproduction to Tazobactam-piperacillin Resistance in Clinical Isolates of Escherichia coli. Int J Antimicrob Agents. 55(4):105919. doi: 10.1016/j.ijantimicag.2020.105919.

  18. Park J-H, Yamaguchi T, Ouchi Y, Mori S, Kim H, Mukai T, Nakajima C, Suzuki Y*. WQ-3810 shows inhibitory activity against quinolone-resistant DNA gyrase of Mycobacterium leprae. J Infect Chemother, 2020 Apr;26(4):335-342, doi:10.1016/j.jiac.2019.10.013. 

  19. Goto S, Konnai S*, Hirano Y, Kohara J, Okagawa T, Maekawa N, Sajiki Y, Watari K, Minato E, Kobayashi A, Gondaira S, Higuchi H, Koiwa M, Tajima M, Taguchi E, Uemura R, Yamada S, Kaneko M, Kato Y, Yamamoto K, Toda M, Suzuki Y, Murata S, Ohashi K. Upregulation of PD-L1 expression by prostaglandin E2 and the enhancement of IFN-γ by anti-PD-L1 antibody combined with a COX-2 inhibitor in Mycoplasma bovis. Front Vet Sci, 2020 Feb 20;7:12, doi: 10.3389/fvets.2020.00012. 

  20. 武田 真理子、 矢萩 洸貴、平田 孝道、黒岩 崇、中島 千絵鈴木 定彦、宗像 文男*. 緩和挙動を用いたポリマー圧電体バイオセンサにおける生体高分子検知特性. 電気学会論文誌, 140(2):43-49.

  21. Honda H, Sato T*, Shinagawa M, Fukushima Y, Nakajima C, Suzuki Y, Kuronuma K, Takahashi S, Takahashi H, Yokota S-I. In vitroDerivation of Fluoroquinolone-resistant Mutants from Multiple Lineages of Haemophilus influenzae and Identification of Mutations Associated with Fluoroquinolone Resistance. Antimicrob Agents Chemother, 2020 Jan 27;64(2). pii: e01500-19. doi: 10.1128/AAC.01500-19. 

  22. Ouchi Y, Mukai T, Koide K, Yamaguchi T, Park J-H, Kim H, Yokoyama K, Tamaru A, Gordon SV, Nakajima C, Suzuki Y*. WQ-3810: a new fluoroquinolone with a high potential against fluoroquinolone-resistant Mycobacterium tuberculosis. Tuberculosis, 2020 Jan;120(2020):101891, doi: 10.1016/j.tube.2019.101891.


Review articles/Book/Text

  1. 今内 覚*、岡川朋弘、前川直也、中島千絵鈴木定彦、山本啓、戸田幹洋、村田史郎、大橋和彦. 動物用抗体医薬品の開発および臨床研究. 日本動物用医薬品協会会報、2020年2月, 67(2):1-10.


 Granted patent

  1. Suzuki Y, Tahara H, Yamamoto K, Kitahara Y, Suzuki Y*, National University Corporation Hokkaido University, Fuso Pharmaceutical Industries, Ltd., Protein substance having triple helix structure and manufacturing method therefor, Hong Kong Patent HK1230218, 2020 May 15.


Applied patents

  1. Suzuki Y, Nakagawa M, Kameda Y, Konnai S, Okagawa T, Maekawa N, Goto S, Sajiki Y, Ohashi K, Murata S, Kitahara Y, Yamamoto K. National University Cooperation Hokkaido University, Fuso Pharmaceutical Industries, Ltd. Novel vector and use thereof. China Application No. 201980033714.3, 2020 November 19.

  2. Suzuki Y, Nakagawa M, Kameda Y, Konnai S, Okagawa T, Maekawa N, Goto S, Sajiki Y, Ohashi K, Murata S, Kitahara Y, Yamamoto K. National University Cooperation Hokkaido University, Fuso Pharmaceutical Industries, Ltd. Novel vector and use thereof. Australia Application No. 2019273200, 2020 November 13.

  3. Suzuki Y, Nakagawa M, Kameda Y, Konnai S, Okagawa T, Maekawa N, Goto S, Sajiki Y, Ohashi K, Murata S, Kitahara Y, Yamamoto K. National University Cooperation Hokkaido University, Fuso Pharmaceutical Industries, Ltd. Novel vector and use thereof. Canada Application No. 05202412 23CA, 2020 November 11.

  4. Suzuki Y, Nakagawa M, Kameda Y, Konnai S, Okagawa T, Maekawa N, Goto S, Sajiki Y, Ohashi K, Murata S, Kitahara Y, Yamamoto K. National University Cooperation Hokkaido University, Fuso Pharmaceutical Industries, Ltd. Novel vector and use thereof. US Application No. 17/054,936, 2020 November 5.

  5. Suzuki Y, Nakagawa M, Kameda Y, Konnai S, Okagawa T, Maekawa N, Goto S, Sajiki Y, Ohashi K, Murata S, Kitahara Y, Yamamoto K. National University Cooperation Hokkaido University, Fuso Pharmaceutical Industries, Ltd. Novel vector and use thereof. Korea Application No. 10-2020-7032057, 2020 November 5.

  6. Suzuki Y, Nakagawa M, Kameda Y, Konnai S, Okagawa T, Maekawa N, Goto S, Sajiki Y, Ohashi K, Murata S, Kitahara Y, Yamamoto K. National University Cooperation Hokkaido University, Fuso Pharmaceutical Industries, Ltd. Novel vector and use thereof. EU Application No. 19806394.3, 2020 November 5.


2019: 24 publications

Original articles: 16, Review articles/Book/Text: 3, Granted patents: 3, Applied patents: 2

 * Corresponding author, ** Equal contribution, Faculty members are underlined.

Original articles with review

  1. Whelan M, Ardill L, Koide K, Nakajima C, Suzuki Y, Simpson J, O'Croinin T*. Acquisition of fluoroquinolone resistance leads to increased biofilm 2 formation and pathogenicity in Campylobacter jejuni. Sci Rep, 2019 Dec 3; 9(1):18216, doi:1038/s41598-019-54620-1

  2. Rao M, RHall H, Lu K, Mason M, Bernabe G, Brennan P, Leitner W, Abnet C, Tsukui K, Yahara K, Yamamoto M, Nakajima C, Totsuka Y. 21st International Conference on Emerging Infectious Diseases in the Pacific Rim. Emerg Infect Dis, 2019 Nov; 25(11): doi: 10.3201/eid2511.191184

  3. Watari K, Konnai S*, Maekawa N, Okagawa T, Suzuki Y, Murata S, Ohashi K. Immune inhibitory function of bovine CTLA-4 and the effects of its blockade in IFN-γ production. BMC Vet Res, 2019 Oct 29;15(1):380. doi: 10.1186/s12917-019-2082-7.

  4. Koide K, Kongsoi S, Nakajima C, Suzuki Y*. WQ-3810 exerts high inhibitory effect on quinolone-resistant DNA gyrase of SalmonellaBiosci Biotech Biochem, 2019 83(12):2249-2256, doi: 10.1080/09168451.2019.1650634.

  5. Sajiki Y, Konnai S*, Okagawa T, Nishimori A, Maekawa N, Goto S, Watari K, Minato E, Kobayashi A, Kohara J, Yamada S, Kaneko M, Kato Y, Takahashi H, Terasaki N, Takeda A, Yamamoto K, Toda T, Suzuki Y, Murata S, Ohashi K. Prostaglandin E2 induced immune exhaustion and enhancement of anti-viral effects by anti-PD-L1 antibody combined with COX-2 inhibitor in bovine leukemia virus infection. J Immunol, 2019 Sep;203(5):1313-1324, doi: 10.4049/jimmunol.1900342.

  6. Kim H, Fukutomi Y, Nakajima C, Kim YU, Mori S, Shibayama K, Nakata N*, Suzuki Y*. DNA gyrase could be a crucial regulatory factor for growth and survival of Mycobacterium leprae. Sci Rep, 2019 July, 9(1):10815, doi: 10.1038/s41598-019-47364-5.

  7. Mendis C, Ratnatunga C, Thevanesam V, Kumara A, Wickramasinghe S, Madagedarae D, Gamage C, Gordon SV, Suzuki Y, Nakajima C*. Insight into genetic diversity of Mycobacterium tuberculosis in Kandy, Sri Lanka reveals predominance of the Euro-American lineage. Int J Infect Dis, 2019 Jul, 87:84-91, doi: 10.1016/j.ijid.2019.07.001.

  8. Thapa J*, Maharjan B, Malla M, Fukushima Y, Poudel A, Pandey BD, Hyashida K, Gordon S, Nakajima C, Suzuki Y*. Direct detection of Mycobacterium tuberculosis in clinical samples by a dry methyl green loop-mediated isothermal amplification (LAMP) method. Tuberculosis. 2019 July;117:1-6. doi: 10.1016/j.tube.2019.05.004.

  9. Usui M*, Kajino A, Kon M, Fukuda A, Sato T, Shirakawa T, Kawanishi M, Harada K, Nakajima C, Suzuki Y, Tamura Y. Prevalence and distribution of 16S-RMTase in gram-negative bacteria derived from companion animals and livestock in Japan. Jpn J Vet Res. 2019 Jun 21,81(6):874-878. doi: 10.1292/jvms.19-0144.

  10. Usui M, Yokoo H, Tamura T, Nakajima C, Suzuki Y, Ghigo JM, and Christophe Beloin*. Zinc acetate potentiates the action of tosufloxacin to efficiently eliminate Escherichia coli persisters in starved biofilm. Antimicrob Agents Chemother. 2019 June 24;63(6). pii: e00069-19. doi: 10.1128/AAC.00069-19.

  11. Paudel S, Nakajima C**, Mikota SK, Gairhe KP, Maharjan B, Subedi S, Poudel A, Sashika M, Shimozuru M, Suzuki Y, Tsubota T*. Mixed Mycobacterium tuberculosis lineage infection in two elephants, Nepal. Emerg Infect Dis. 2019 May;25(5):1031-1032. doi: 10.3201/eid2505.181898.

  12. Hiyama Y*, Takahashi S, Sato T, Shinagawa M, Fukushima Y, Nakajima C, Suzuki Y, Masumori N, Yokota S-I. Evaluation of susceptibilities to carbapenems and faropenem against cephalosporin-resistant Neisseria gonorrhoeae clinical isolates with penA mosaic alleles. Microb Drug Resist. 2019 Apr;25(3):427-433. doi: 10.1089/mdr.2018.0263.

  13. Shah Y*, Poudel A, Maharjan B, Thapa J, Yamaguchi T, Diab HM, Pandey BD, Solo E, Isoda N,Suzuki YNakajima C*. Genetic diversity of Mycobacterium tuberculosis Central Asian Strain isolates from Nepal and comparison with neighboring countries. Trans R Soc Trop Med Hyg. 2019 Apr 1;113(4):203-211. doi: 10.1093/trstmh/try136.

  14. Phetsuksiri B, Rudeeaneksin J, Srisungngam S, Bunchoo S, Klayut W, Sangkitporn S, Nakajima C, Hamada S, Suzuki Y. Loop-mediated isothermal amplification for rapid identification of Mycobacterium tuberculosis in comparison with immunochromatographic SD Bioline MPT64 Rapid® in a high burden setting. Jpn J Infect Dis. 2019 Mar 25;72(2):112-114. doi: 10.7883/yoken.JJID.2018.128.

  15. Fujisawa S, Konnai S, Okagawa T, Maekawa N, Tanaka A, Suzuki Y, Murata S, Ohashi K. Effects of bovine tumor necrosis factor alpha decoy receptors on cell death and inflammatory cytokine kinetics: Potential for bovine inflammation therapy. BMC Vet Res, 2019 Feb 28;15(1):68. doi: 10.1186/s12917-019-1813-0.

  16. Koide K, Kongsoi S, Ouchi Y, Yamaguchi T, Nakajima C, Suzuki Y*. Antibacterial activity of DC-159a against Salmonella Microb Drug Resist. 2019 Jan/Feb;25(1):14-22. doi: 10.1089/mdr.2018.0078.0078.


Review articles/Book/Text: 

  1. 鈴木定彦*.ワンヘルスの理念と人獣共通感染症制圧への取り組み:ザンビアでの活動. LABIO21、2019、75(1):14-18

  2. 竹内 寛人, 前川 直也, 今内 覚*, 高木 哲, 細谷 謙次, 賀川 由美子, 岡川 朋弘, 鈴木 定彦, 山本 啓一, 村田 史郎, 大橋 和彦. 2019. 免疫チェックポイント分子Programmed death‐ligand 1(PD‐L1)を標的とする抗体薬による免疫療法が奏功した肺転移のある口腔内悪性黒色腫の犬の1例. 北海道獣医師会雑誌. 63(8): 343.

  3. 今内 覚*, 岡川 朋弘, 前川 直也, 中島 千絵, 鈴木 定彦, 山本 啓一, 戸田 幹洋, 村田 史郎, 大橋 和彦. 2019. 免疫学的解析を基盤とした動物用創薬研究. 臨床獣医. 37(3): 37-41.


Granted patents: 

  1. Suzuki Y, Tahara H, Yamamoto K, Kitahara Y, Suzuki Y, National University Corporation Hokkaido University, Fuso Pharmaceutical Industries, Ltd., Protein substance having triple helix structure and manufacturing method therefor, Hong Kong Patent ZL2, 2019 Oct 9.

  2. Suzuki Y, Tahara H, Yamamoto K, Kitahara Y, Suzuki Y, National University Corporation Hokkaido University, Fuso Pharmaceutical Industries, Ltd., Protein substance having triple helix structure and manufacturing method therefor, China Patent 2, 2019 July 18.

  3. Tahara H, Suzuki Y, Yamamoto K, Kitahara Y, Suzuki Y. National University Corporation Hokkaido University, Fuso Pharmaceutical Industries, Ltd., Expression vector for producing protein derived from foreign gene in large quantity using animal cells, and use thereof, Canada Patent 2748011, 2019 Mar 26.


Applied patents: 2

  1. 鈴木定彦、中川美樹、亀田弥生、今内覚、岡川朋弘、前川直也、後藤伸也、佐治木大和、大橋和彦、村田史郎、北原譲、山本啓一.  国立大学法人北海道大学、扶桑薬品工業:新規ベクターおよびその利用. PCT/JP2019/18899. 2019 May 13

  2. 大村智、森美穂子、松本厚子、塩見和朗、鈴木定彦中島千絵、山口智之. 学校法人北里研究所、国立大学法人北海道大学:新規K95-5901-1物質およびその製造方法. PCT/JP2019/13132, 2019 Mar 27.


2018: 16 publications

Original articles: 10, Review articles/Book/Text: 3Applied patents: 3

 * Corresponding author, ** Equal contribution, Faculty members are underlined.

Original articles with review 

  1. Cambau E*, Saunderson P, Matsuoka M, Cole ST, Kai M, Suffys P, Rosa PS, Williams D, Gupta UD, Lavania M, Cardona-Castro N, Miyamoto Y, Hagge D, Srikantam A, Hongseng W, Indropo A, Vissa V, Johnson RC, Cauchoix B, Pannikar VK, Cooreman EAWD, Pemmaraju VRR, Gillini L, Kriswamati A, Al-Samie AR, Issoufou A, Tiendrebeogo A, Kingalu A, Randrianantoandro A, Kumar A, Chauffour A, Win AA, Pandey B, Agrawal CM, Widaningrum C, Schmotzer C, Kafando C, Bhandari CM, Sema C, Vidanagama DS, Scollard DM, Beyene D, Morelo EF, Kassa ED, Ramarolahy EB, Claco E, Villalon EE, Sidibe F, Sakho F, Abdoulaye F, Guilengue FF, Gajete F, Babu GR, Moussa G, Thakur GD, Cabanos G, Sock G, Clugston G, Zaidy H, Watanabe H, Kawuma HJ, Mallari IB, Goulart IMB, Ahamed I, Subbanna J, Houzeo JG, Luengu JNM, Bertolli J, Lloyd-Owen J, Matheu J, Brunelli JP, Alzate JCB, Neupane KD, Osuga K, Yamaguchi K, Azam K, Lin KM, Momoudu K, Kyaw K, Bide L, Doanh LH, My LH, Shah M, Kodio M, Sidibe M, Ebenezer M, Grossi MAF, Balagon MF, Canlonon M, Makino M, Htoo MM, Ahmed MJ, Nadine MM, Roferos FO, Krismawati H, Thida M, Htoon MT, Neupane KD, Nguyen Phuc NH, Van NH, Hai NPN, Ishii N, Soe O, Amiel O, Tossou O, Konare O, Joshi PL, Ranganadha Rao PV, Krishnamurthy P, Brennan PJ, Busso P, Bhatia R, Rakoto Andrianarivelo M, Ramdas DR, Chabi R, Gusmao R, DjupuriIzwardy R, Soares RCFR, Jhadav R, Buhrer S, Cho SR, Jianping S, Lzumi S, Barua S, Chaitanya S, Tiendrebeogo SMR, Khang TH, Gillis TP, Mori T, Vijayalakshmi V, Kamara VD, Wei W, Smith WCS, Li W, Lew W, Al-Qubati Y, Suzuki Y, Nanba Y. Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009-15. Clin Microbiol Infect. 2018 Dec;24(12):1305-1310. doi: 10.1016/j.cmi.2018.02.022.

  2. Maharjan B, Nakajima C, Isoda N, Thapa J, Poude A, Shah Y, Yamaguchi T, Shrestha S, Hoffmann H, Avsar K, Shrestha A, Gordon SV, Suzuki Y*. Genetic diversity and distribution dynamics of multidrug-resistant Mycobacterium tuberculosis isolates in Nepal. Sci Rep. 2018 Nov 9;8(1):16634. doi: 10.1038/s41598-018-34306-w.

  3. Lai Lai San, Khin Saw Aye, Nan Aye Thida Oo, Mu Mu Shwe, Fukushima Y, Gordon SV, Suzuki Y, Nakajima C*. Insight into multidrug-resistant Beijing genotype Mycobacterium tuberculosis isolates in Myanmar. Int J Infect Dis. 2018 Nov;76:109-119. doi: 10.1016/j.ijid.2018.06.009.

  4. Honda H, Sato T*, Shinagawa M, Fukushima Y, Nakajima C, Suzuki Y, Shiraishi T, Kuronuma K, Takahashi S, Takahashi H, Yokota S-I (2018) Multiclonal expansion and high prevalence of β-lactamase-negative high-level ampicillin-resistant Haemophilus influenzae in Japan, and susceptibility to quinolones. Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00851-18. doi: 10.1128/AAC.00851-18.

  5. Ohkoshi Y, Sato T*, Wada T, Fukushima Y, Murabayashi H, Takakuwa Y, Nishiyama K, Shiraishi T, Nakajima C, Suzuki Y, Yokota S-I. Whole genome analysis of a multidrug-resistant Streptococcus pneumoniae isolate from a patient with invasive pneumococcal infection developing disseminated intravascular coagulation. J Infect Chemother. 2018 Aug;24(8):674-681. doi: 10.1016/j.jiac.2018.01.012.

  6. Yoshida S, Araki T, Asai T, Tsuyuguchi T, Arikawa K, Iwamoto T, Nakajima C, Suzuki Y, Ohya K, Yanai T, Yamamoto T, Wada T*. Phylogenetic uniqueness of Mycobacterium avium subspecies hominissuis isolated from an abnormal pulmonary bovine case. Infect Genet Evol. 2018 Aug;62:122-129. doi: 10.1016/j.meegid.2018.04.013.

  7. Nan Aye Thida Oo, Lai Lai San, Thapa J, Khin Saw Aye, Wah Wah Aung, Nakajima C, Suzuki Y*. Characterization of mutations conferring streptomycin resistance to multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar. Tuberculosis 2018 Jul;111:8-13. doi: 10.1016/j.tube.2018.05.003.

  8. Okagawa T, Konnai S*, Nishimori A, Maekawa N, Goto S, Ikebuchi R, Kohara J, Suzuki Y, Yamada S, Kato Y, Murata S, Ohashi K. Cooperation of PD-1 and LAG-3 in the exhaustion of CD4+ and CD8+ T cells during bovine leukemia virus infection. Vet Res. 2018 Jun 19;49(1):50. doi: 10.1186/s13567-018-0543-9.

  9. Sajiki Y, Konnai S*, Okagawa T, Nishimori A, Maekawa N, Goto S, Ikebuchi R, Nagata R, Kawaji S, Kagawa Y, Yamada S, Kato Y, Nakajima C, Suzuki Y, Murata S, Mori Y, Ohashi K. Prostaglandin E2 induction suppresses the Th1 immune responses in cattle with Johne’s disease. Infect Immun. 2018 Apr 23;86(5). pii: e00910-17. doi: 10.1128/IAI.00910-17.

  10. Bwalya P, Yamaguchi T, Mulundu G, Nakajima C, Mbulo G, Solo ES, Fukushima Y, Kasakwa K, Suzuki Y*. Genotypic characterization of pyrazinamide resistance in Mycobacterium tuberculosis isolated from Lusaka, Zambia. Tuberculosis (Edinb). 2018 Mar;109:117-122. doi: 10.1016/j.tube.2017.12.007.


Review articles/Book/Text: 

  1. 山口智之、中島千絵鈴木定彦*. (2018) 結核菌の薬剤耐性獲得. 呼吸器ジャーナル. 2018 Nov;64(4):650-656.

  2. 今内覚*、岡川朋弘、前川直也、中 島千 絵鈴木定彦、山本啓一、戸田幹洋、村田史郎、大橋和彦. 動物難治性疾病に対する創薬研究. MPアグロジャーナ. 2018 Oct;35(10):22-5.

  3. Villanueva MA, Mingala CN, Nakajima C, Suzuki Y*. Emerging Infectious Diseases in Water Buffalo – An economic and Public Health Concern. InTech Open Access Publisher, Rijeka, Croatia. 2018 Mar;ISBN 978-953-51-3831-0.


Applied patents: 

  1. 鈴木定彦、中川美樹、亀田弥生、今内覚、岡川朋弘、前川直也、後藤伸也、佐治木大和、大橋和彦、村田史郎、北原譲、山本啓一. 新規ベクターおよびその利用. 国立大学法人北海道大学、扶桑薬品工業:特願2018-99704. (日本) 2018年5月24日

  2. 大村智、森美穂子、松本厚子、塩見和朗、鈴木定彦中島千絵、山口智之. 学校法人北里研究所、国立大学法人北海道大学:新規K95-5901-1物質およびその製造方法. 特願2018-061397. (日本)2018年3月28日

  3. 今内覚、大橋和彦、村田史郎、岡川朋弘、前川直也、西森朝美、後藤伸也、鈴木定彦中島千絵.PD-1/PD-L1を標的とする阻害薬とCOX-2阻害薬との併用.国立大学法人北海道大学、扶桑薬品工業:特願2018-16074. (日本) 2018年2月1日


2017: 27 publications

Original articles: 20, Review articles/Book/Text: 4, Granted patents: 1, Applied patents: 2

 * Corresponding author, ** Equal contribution, Faculty members are underlined.

Original articles with review

  1. Sato T, Ohkoshi Y, Wada T, Fukushima Y, Murabayashi H, Takakuwa Y, Nishiyama K, Shiraishi T, Nakajima C, Suzuki Y, Yokota S-I (2017) Complete Genome Sequence of a Multidrug-Resistant Streptococcus pneumoniae Serotype 19F Isolated from Invasive Infection in Sapporo, Japan. Genome Announc. 5(44):e01239-17; doi:10.1128/genomeA.01239-17. (November)

  2. Rahim Z, Thapa J, Fukushima Y, van der Zanden AGM, Gordon SV, Suzuki Y, Nakajima C* (2017) Tuberculosis caused by Mycobacterium orygis in dairy cattle and captured monkeys in Bangladesh: a new scenario of tuberculosis in South Asia. Transbound Emerg Dis, 64 (6):1965–1969, doi: 10.1111/tbed.12596. (November)

  3. Utrarachkij F, Nakajima C**, Changkwanyeun R, Siripanichgon K, Kongsoi S, Pornruangwong S, Changkaew K, Tsunoda R, Tamura Y, Suthienkul O, Suzuki Y* (2017) Quinolone Resistance Determinants of Clinical Salmonella Enteritidis in Thailand. Microbial Drug Resistance, 23(7):885-894, doi: 10.1089/mdr.2015.0234. (October)

  4. Prapasawat W, Intarapuk A, Choompook P, Nakajima C, Suzuki Y, Suthienkul O (2017) Antimicrobial resistance, integrin, virulence gene, and molecular sequence typing of Escherichia coli isolates from postweaning piglets with and without diarrhea. Southeast Asian J Trop Med Public Health, 48(5):1042-1055. (September)

  5. Yano H, Iwamoto T, Arikawa K, Nishiuchi Y, Nakajima C, Suzuki Y, Starkova D, Mokrousov I, Narvskaya O, Yoshida S, Nakanishi N, Osaki K, Nakagawa I, Maruyama F (2017) Populations structure and local adaptation of MAC lung disease agent Mycobacterium avium subsp. hominissuis. Genome Biology and Evolution, 9(9):2403-2417, doi: 10.1093/gbe/evx183. (September)

  6. Goto S, Konnai S, Okagawa T, Nishimori A, Maekawa N, Gondaira S, Higuchi H, Koiwa M, Tajima M, Kohara J, Ogasawara S, Kato Y, Suzuki Y, Murata S, Ohashi K. (2017) Increase of cells expressing PD-1 and PD-L1 and enhancement of IFN-γ production via PD-1/PD-L1 blockadein bovine mycoplasmosis. Immunity Inflam Dis, 5(3):355-363, doi: 10.1002/iid3.173. (September)

  7. Maekawa N, Konnai S, Takagi S, Kagawa Y, Okagawa T, Nishimori A, Ikebuchi R, Izumi Y, Deguchi T, Nakajima C, Kato Y, Yamamoto K, Uemura H, Suzuki Y, Murata S, Ohashi K (2017) A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma. Sci Rep, 7(1):8951. (August)

  8. Pan XL, Zhang CL, Nakajima C, Fu J, Shao CX, Zhao LN, Cui JY, Jiao N, Fan CL, Suzuki Y, Hattori T, Li D, Ling H. (2017) A quantitative and efficient approach to select MIRU-VNTR loci based on accumulation of the percentage differences of strains for discriminating divergent Mycobacterium tuberculosis sublineages. Emerg Microb Infect, 6(7):e68. doi: 10.1038/emi.2017.58. (July)

  9. Yamaguchi T, Yokoyama K, Nakajima C, Suzuki Y* (2017) Quinolone resistance-associated amino acid substitutions affect enzymatic activity of Mycobacterium leprae DNA gyrase. Biosci Biotech Biochem, 81(7):1343-1347, doi: 10.1080/09168451.2017.1314757. (July)

  10. Shaha Y, Maharjan B, Thapa J, Poudel A, Diab HM, Pandey BD, Solo E, Isoda N, Suzuki Y, Nakajima C (2017) High diversity of multidrug resistant Mycobacterium tuberculosis Central Asian Strain isolates in Nepal. Int J Infect Dis, 63:13-20. doi: 10.1016/j.ijid.2017.06.010. (June)

  11. Habeenzu C, Nakajima C, Solo E, Bwalya P, Kajino K, Miller M, Kurosawa Y, Mudenda V, Kasonka L, Suzuki Y*, Matsuba T (2017) Evaluation of in-house loop-mediated isothermal amplification for the diagnosis of tuberculosis in comparison with GeneXpert MTB/RIF. J Infect Dev Ctries, 11(6):440-444. doi:10.3855/jidc.7730 (June)

  12. Okagawa T, Konnai S, Nishimori A, Maekawa N, Ikebuchi R, Goto S, Nakajima C, Kohara J, Ogasawara S, Kato Y, Suzuki Y, Murata S, Ohashi K (2017) Anti-Bovine PD-1 Bovine–Rat Chimeric Antibody for Immunotherapy of Bovine Leukemia Virus Infection in Cattle. Frontiers in Immunology, 8:650, doi: 10.3389/fimmu.2017.00650 (June)

  13. Kabongo PN, Obi CL, Nakajima C, Suzuki Y, Hattori T, Eloff JN, Wright J, Mbelle N, McGaw LJ (2017) Novel Mycobacterium avium species isolated from Black Wildebeest (Connochaetes gnou) in South Africa. Transbound Emerg Dis, 64(3):929-937, doi: 10.1111/tbed.12460. (June)

  14. Zhao J, Matsuba T, Zhang XY, Leano S, Nakajima C, Chagan-Yasutan H, Telan EF, Suzuki Y, Hattori T (2017) Comparison of antibody responses against Mycobacterium tuberculosis antigen Rv0679c in tuberculosis patients from the endemic and non-endemic regions of the Beijing genotype: a case control study. BMC infect dis, 17(1):344. doi: 10.1186/s12879-017-2442-5. (May)

  15. Nishimori A, Konnai S, Okagawa T, Maekawa N, Goto S, Sajiki Y, Suzuki Y, Kohara J, Ogasawara S, Kato Y, Murata S, Ohashi K (2017) In vitro and in vivo antivirus activity of an anti-programmed death-ligand 1 (PD-L1) rat-bovine chimeric antibody against bovine leukemia virus infection. PLOS ONE, 12(4):e0174916, doi: 10.1371/journal.pone.0174916. (April)

  16. Hwang I, Mori K, Ohtani K, Matsuda Y, Roy N, Kim Y-U, Suzuki Y, Wakamiya N (2017) Collectin Kidney 1 Plays an Important Role in Innate Immunity against Streptococcus pneumoniae Infection. J. Innate Immun, 9:217-228, doi: 10.1159/000453316. (March)

  17. Thanda Tun, Khin Saw Aye, Wint Wint Nyunt, Crump JA, Nakajima C, Suzuki Y, Kyi Kyi Thinn, Cook GM, Htin Lin Aung (2017) Genotypic Diversity of Mycobacterium tuberculosis strains in Myanmar. Infect Dis, 49(3):237-239, 10.1080/23744235.2016.1231419. (March)

  18. Usui M, Kawakura M, Yoshizawa N, Lai Lai San, Nakajima C, Suzuki Y, Tamura Y (2017) Survival and prevalence of Clostridium difficile in manure compost derived from pigs. Anaerobe, 43(2017):15-20 doi: 10.1016/j.anaerobe.2016.11.004. (February)

  19. Zhao J, Shirator B, Matsumoto M, Nakajima C, Okumura M, Yoshiyama T, Yanai H, Mizuno K, Ono K, Oda T, Ashino Y, Matsuba T, Suzuki Y, Hattori T (2017) Difference in antibody responses to Mycobacterium tuberculosis antigens in Japanese tuberculosis patients infected with the Beijing/non-Beijing genotype. J Immun Res, 2017(2017):4797856. doi.org/10.1155/2017/4797856 (January)

  20. Shiratori B, Zhao J, Okumura M, Chagan-Yasutan H, Yanai H, Mizuno K, Yoshiyama T, Idei T, Ashino Y, Nakajima C, Suzuki Y, Hattori T (2017) Immunological roles of elevated plasma levels of matricellular proteins in Japanese patients with pulmonary tuberculosis. International Journal of Molecular Sciences, 18(1):19. doi.org/10.1016/j.anaerobe.2016.11.004. (January)


Review articles/Book/Text: 4

 (*Corresponding author, ** Equal contribution)

  1. 鈴木定彦*、中島千絵 (2017) 薬剤耐性獲得機構と多剤耐性結核菌:結核 改訂版(光山正雄、鈴木克洋 編、医薬ジャーナル社、大阪)分担執筆 II章-4項, pp70-84 (July)

  2. Kongsoi S, Nakajima C, Suzuki Y* (2017) Quinolone Resistance in Non-typhoidal Salmonella. In “Current Topics in Salmonella and Salmonellosis”, Mares M (eds.), Intech Open Access Publisher, Rijeka, Croatia, Chapter 7: pp115-135 (April)

  3. Thapa J, Nakajima C**, Gairhe KP, Maharjan B, Paudel S, Shah Y, Mikota SK, Kaufman GE, McCauley D, Tsubota T, Gordon SV, Suzuki Y* (2017) Wildlife tuberculosis: An emerging threat for conservation in South Asia. In “Global Exposition of Wildlife Management”. Cardona P-J (eds.), Intech Open Access Publisher, Rijeka, Croatia, Chapter 5: pp73-90 (March)

  4. 鈴木定彦*、中島千絵 (2017) 結核と非結核性抗酸菌症.化学療法の領域 33(3)411-18. (March)


Granted patent: 1

  1. Suzuki Y, Tahara H, Yamamoto K, Kitahara Y, Suzuki Y. Protein substance having triple helix structure and manufacturing method therefor. Canada Patent 2748015. 2017年2月28日 (February)


Applied patents: 2

  1. 今内覚、大橋和彦、村田史郎、岡川朋弘、前川直也、西森朝美、後藤伸也、鈴木定彦中島千絵.PD-1/PD-L1を標的とする阻害薬とCOX-2阻害薬との併用.特願2017-140891(日本)2017年7月20日 (July)

  2. 今内覚、大橋和彦、村田史郎、岡川朋弘、西森朝美、前川直也、高木哲、賀川由美子、鈴木定彦中島千絵. PD‐L1検出用抗PD‐L1抗体. 特願2017-61389 (日本)2017年3月27日 (March)


2016: 36 publications

Original articles: 20, Review articles/Book/Text: 5, Granted patents: 7, Applied patents: 4

 *Corresponding author, ** Equal contribution, Faculty members are underlined. 

Original articles with review

  1. Musinguzi SP, Suganuma K, Asada M, Laohasinnarong D, Sivakumar T, Yokoyama N, Namangala B, Sugimoto C, Suzuki Y, Xuan X, Inoue N. (2016) A PCR-based survey of animal African trypanosomosis and selected piroplasm parasites of cattle and goats in Zambia. J Vet Med Sci, in press, doi: 10.1292/jvms.16-0240. (December)

  2. Villanueva MA, Mingala CN, Balbin MM, Nakajima C, Isoda N, Suzuki Y*, Koizumi N. (2016) Molecular epidemiology of pathogenic Leptospira spp. among large ruminants in the Philippines. J Vet Med Sci, 78(11):1649-55, doi: 10.1292/jvms.16-0289 (November)

  3. Changkwanyeun R, Yamaguchi T, Kongsoi S, Changkaew K, Yokoyama K, Kim H, Suthienkul O, Usui M, Tamura Y, Nakajima C, Suzuki Y* (2016) Impact of mutations in DNA gyrase genes on quinolone resistance in Campylobacter jejuni. Drug Test Anal, 8(10):1071-76, doi: 10.1002/dta.1937. (October)

  4. Kongsoi S, Changkwanyeun R, Yokoyama K, Nakajima C, Changkaew K, Suthienkul O, Suzuki Y* (2016) Amino Acid Substitutions in GyrA Affect Quinolone Susceptibility in Salmonella Typhimurium. Drug Test Anal, 8(10):1065-70, doi: 10.1002/dta.1910. (October)

  5. Chagan-Yasutan H, Chen Y, Lacuesta TL, Leano PSA, Iwasaki H, Hanan F, Taurustiati D, Ohmoto Y, Ashino Y, Saitoh H, Kiyomoto H, Suzuki Y, Telan FOE, Hattori T (2016) Urine Levels of Defensin Alpha1 Reflect Kidney Injury Caused by Neutrophil Involvement in Leptospirosis Patients. Int J Mol Sci, 7(10), 1637, doi:10.3390/ijms17101637. (October)

  6. Yamaguchi T, Yokoyama K, Nakajima C, Suzuki Y* (2016) DC-159a shows inhibitory activity against DNA gyrases of Mycobacterium leprae. PLoS Neglect Tropical Dis, 10 (2016) e0005013, doi: 10.1371/journal.pntd.0005013 (September)

  7. Seyama T, Hirayasu H, Yoshida G, Ohnuma A, Qiu Y, Nakajima C, Kasai K, Suzuki Y. (2016) The effects of administering lactic acid bacteria sealed in a capsule on the intestinal bacterial flora of cattle.  Jpn J Vet Res, 64(3): 197-203, doi: 10.14943/jjvr.64.3.197 (August)

  8. Paudel S, Villanueva MA, Mikota SK, Nakajima C, Gairhe KP, Subedi S, Rayamajhi N, Sashika M, Shimozuru M, Matsuba T, Suzuki Y*, Tsubota T* (2016) Development and evaluation of an interferon-γ release assay (IGRA) in Asian elephants (Elephas maximus). J Vet Med Sci, 78(7):1117-21, doi: 10.1292/jvms.15-0701 (July)

  9. Maekawa N, Konnai S, Okagawa T, Nishimori A, Ikebuchi R, Izumi Y, Takagi S, Kagawa Y, Nakajima C, Suzuki Y, Kato Y, Murata S, Ohashi K (2016) Immunohistochemical Analysis of PD-L1 Expression in Canine Malignant Cancers and PD-1 Expression on Lymphocytes in Canine Oral Melanoma. PLoS ONE, 11(6):e0157176, doi: 10.1371/journal.pone.0157176 (June)

  10. Roy N, Ohtani K, Matsuda Y, Mori K, Hwang I, Suzuki Y, Inoue N, Wakamiya N (2016) Collectin CL-P1 utilizes C-reactive protein for complement activation. Biochim Biophys Acta-Gen Subj, 1860(6):1118-28, doi: 10.1016/j.bbagen.2016.02.012 (June)

  11. Matsuba T, Siddiqi U, Hattori T, Nakajima C, Fujii J, Suzuki Y (2016) Antigenic characterisation of dimorphic surface protein in Mycobacterium tuberculosis. FEMS Microbiol Lett, 363(10):fnw082, doi: 10.1093/femsle/fnw082 (May)

  12. Chishimba K, Hang'ombe BM, Muzandu K, Mshana SE, Matee MIN, Nakajima C, Suzuki Y (2016) Detection of Extended Spectrum Beta-Lactamase Producing Escherichia coli in Market Ready Chickens in Zambia. Int J Microbiol, 2016: 5275724, doi: 10.1155/2016/5275724 (April)

  13. Chonsin K, Matsuda S, Theethakaew C, Kodama T, Junjhon J, Suzuki Y, Suthienkul O, Iida T (2016) Genetic diversity of Vibrio parahaemolyticus strains isolated from farmed Pacific white shrimp and ambient pond water affected by acute hepatopancreatic necrosis disease outbreak in Thailand. FEMS Microbiol Lett, 363(2):fnv222, doi: 10.1093/femsle/fnv222 (April)

  14. Utrarachkij F, Nakajima C**, Siripanichgon K, Changkaew K, Thongpanich Y, Pornraungwong S, Suthienkul O, Suzuki Y* (2016) Genetic Diversity and Antimicrobial Resistance Pattern of Salmonella enterica serovar Enteritidis Clinical Isolates in Thailand. J Infect Chemother, 22(4):209-15, doi: 10.1016/j.jiac.2015.12.011 (April)

  15. Iwasaki H, Chagan-Yasutan H, Leano PS, Koizumi N, Nakajima C, Taurustiati D, HananF, Lacuesta TL, Ashino Y, Suzuki Y, Gloriani NG, Telan EF (2016) Combined antibody and DNA detection for early diagnosis of leptospirosis after a disaster. Diagn Microbiol Infect Dis, 86(4):287-91. doi: 10.1016/j.diagmicrobio.2016.01.001 (April)

  16. Thapa J, Paudel S, Sadaula A, Shah Y, Maharjan B, Kaufman GE, McCauley D, Gairhe KP, Tsubota T, Suzuki Y, Nakajima C* (2016) Tuberculosis caused by Mycobacterium orygis in a free-ranging rhinoceros (Rhinoceros unicornis) in Nepal. Emerg Infect Dis, 22(3): 570–2, doi: 10.3201/eid2203.151929 (March)

  17. Templeton T, Asada M, Jiratanh M, Ishikawa S, Tiawsirisup S, Sivakumar T, Namangala B, Takeda M, Mohkaew K, Ngamjituea S, Inoue N, Sugimoto C, Inagaki Y, Suzuki Y, Yokoyama N, Kaewthamasorn M, Kaneko O (2016) Ungulate malaria parasites. Sci Rep-UK, 6:23230, doi: 10.1038/srep23230 (March)

  18. Khin Saw Aye, Nakajima C**, Yamaguchi T, Min Min Win, Mu Mu Shwe, Aye Aye Win, Thandar Lwin, Wint Wint Nyunt, Ti Ti, Suzuki Y* (2016) Genotypic Characterization of Multi-drug-Resistant Mycobacterium tuberculosis isolates in Myanmar. J Infect Chemother, 22(3):174-9, doi: 10.1016/j.jiac.2015.12.009 (February)

  19. Villanueva MA, Mingala CN, Gloriani NG, Yanagihara Y, Isoda N, Nakajima C, Suzuki Y*, Koizumi N (2016) Serological investigation of Leptospira infection and its circulation in one intensive-type water buffalo farm in the Philippines. Jpn J Vet Res, 64(1):15-24, doi: 10.14943/jjvr.64.1.15 (January)

  20. Diab HM, Nakajima C, Kotb SA, Mokhtar A, Khder NFM, Abdelaal ASA, Hegazy A, Poudel A, Shah Y, Suzuki Y* (2016) First insight into the genetic population structure of Mycobacterium tuberculosis isolated from pulmonary tuberculosis patients in Egypt. Tuberculosis, 96:13-20, doi: 10.1099/jmm.0.000178 (January)


Review articles/Book/Text: 5

  1. 中島千絵*、鈴木定彦(2016)人獣共通感染症としての結核.J. Vet. Epidemiol., 20(2):101-104

  2. 臼井優、舘野翔、田勢準也、田村豊、中島千絵鈴木定彦、小野崎正修、大曽根司郎(2016)マイクロアレイ技術を応用した薬剤耐性カンピロバクターの迅速検出法(CAMERA法). グリーンテクノ情報 12(2):14-7.(September)

  3. Hattori T, Chagan-Yasutan H, Shiratori B, Egawa S, Izumi T, Kubo T, Nakajima CSuzuki Y, Niki T, Telan E (2016) Development of Point-of-Care Testing for Disaster-Related Infectious Diseases. Tohoku J Exp Med, 238(4):287-93, doi: 10.1620/tjem.238.287 (April)

  4. 鈴木定彦*、中島千絵 (2016) 結核 ―人獣共通感染症の観点から 臨床と微生物 43(2):169-73. (March)

  5. 鈴木定彦* (2016)  結核:人獣共通感染症 第3版(木村哲、喜田宏 編、医薬ジャーナル社、大阪)分担執筆 結核 pp356 - 9. (January)


Granted patents: 7

  1. Suzuki Y, Yamamoto K, Suzuki Y, Tahara H. Protein substance having triple helix structure and manufacturing method therefor cell and use thereof. Korea patent 10-1686688. December 8, 2016.

  2. Tahara H, Suzuki Y, Yamamoto K, Kitahara Y, Suzuki Y. Expression vector for producing protein derived from foreign gene in large quantity using animal cells, and use thereof. EU patent 2258843. November 11, 2016.

  3. 鈴木定彦、山本啓一、田原寛、鈴木祐介. 動物細胞を用いて外来遺伝子由来タンパク質を大量に生産するための発現ベクター、およびその利用. 日本国特許第6022518号. October 14, 2016.

  4. Tahara H, Suzuki Y, Yamamoto K, Kitahara Y, Suzuki Y. Expression vector for producing protein derived from foreign gene in large quantity using animal cells, and use thereof. Korea Patent 10-1655492. September 1, 2016.

  5. Suzuki Y, Yamamoto K, Suzuki Y, Tahara H. Expression vector for Mass production of foreign gene-derived protein using animal cell and use thereof. Hong Kong patent HK1155772. June 10, 2016.

  6. Suzuki Y, Yamamoto K, Suzuki Y, Tahara H. Expression vector for Mass production of foreign gene-derived protein using animal cell and use thereof. Korea Patent 10-1604502. March 11, 2016

  7. Tahara H, Suzuki Y, Yamamoto K, Kitahara Y, Suzuki Y. Expression vector for producing protein derived from foreign gene in large quantity using animal cells, and use thereof. Hong Kong Patent HK1161898. February 26, 2016.


Applied patents: 4

  1. 今内 覚、大橋和彦、村田史郎、岡川朋弘、西森朝美、前川直也、鈴木定彦、中島千絵. 抗PD-L1抗体. 特願2016-159088(日本). 2016年8月15日

  2. 今内 覚、大橋和彦、村田史郎、岡川朋弘、西森朝美、前川直也、鈴木定彦、中島千絵. ウシ用抗PD-L1抗体. 特願2016-159089(日本). 2016年8月15日

  3. 今内 覚、大橋和彦、村田史郎、岡川朋弘、西森朝美、前川直也、鈴木定彦、中島千絵. 抗PD-1抗体. 特願2016-159090(日本). 2016年8月15日

  4. 今内 覚、大橋和彦、村田史郎、岡川朋弘、西森朝美、前川直也、鈴木定彦、中島千絵. 抗LAG-3抗体. 特願2016-159091(日本). 2016年8月15日


2015: 22 publications

Original articles: 12, Review articles/Book/Text: 3, Granted patents: 7

 *Corresponding author, ** Equal contribution, Faculty members are underlined. 

Original articles with review

  1. Yoda T,  Suzuki Y,  Aoyama I,  Yamazaki K,  Nakata S,  Takahashi K (2015)  No crucial amino acid changes in the predicted Hisato Blood Group Antigen binding sites of the Norovirus GII.4 capsid between non-secretors and secretors origin might suggest an alternative route of infection or ezistence of coincidental molecules.  J Med Microbiol,  64(12):1544-7

  2. Koizumi N,  Izumiya H,  Mu JJ,  Arent Z,  Okano S, Nakajima C,  Suzuki Y,  Mizutan-Muto M,  Tanikawa T,  Taylor KR,  Komatsu N,  Yoshimatsu K,  Ha HTT,  Ohnishi M (2015)  Multiple-locus variable-number tandem repeat analysis of Leptospira interrogans and Leptospira borgpetersenii isolated from small feral and wild mammals in East Asia.  Infect Genet Evol,  36:434-40

  3. Senoputra M, Shiratori B, Hasibuan F, Koesoemadinata R, Apriani L, Ashino Y, Ono K, Oda T, Matsumoto M, Suzuki Y, Alisjahban B, Hattori T. (2015) Diagnostic value of antibody responses to multiple antigens from Mycobacterium tuberculosis in active and latent tuberculosis. Diag Microbiol Infect Dis 83(3):278-285.

  4. Thapa J, Nakajima C, Maharjan B, Poudel A, Suzuki Y. (2015) Molecular characterization of Mycobacterium orygis isolates from wild animals of Nepal. Jpn J Vet Res 94(3):287-92.

  5. Kawahara R, Seto K, Taguchi M, Nakajima C, Kumeda Y, Suzuki Y. (2015) Characterization of third-generation cephalosporin-resistant Shiga toxin-producing strains of Escherichia coli O157:H7 in Japan. J Clin Microbiol 53(9):3035-8.

  6. Kongsoi S, Yokoyama K, Suprasert A, Utrarachkij F, Nakajima C, Suthienkul O, Suzuki Y. (2015) Characterization of Salmonella Typhimurium DNA Gyrase as a Target of Quinolones. Drug Test Annal 7(8):714-20.

  7. Zhao J, Zhu Z, Zhang X, Suzuki Y, Chagan-Yasutan H, Chen H, Wan Y, Xu J, Ashino Y, Hattori T. (2015) Evaluation of anti-TBGL antibody in TB patients in China: anti-TBGL antibody titers elevated in pulmonary TB patients presenting with cavitation or bronchiectasis. J Immunol Res 2015:834749.

  8. Changkaew K, Intarapuk A, Utrarachij F, Nakajima C, Suthienkul O, Suzuki Y. (2015) Antimicrobial Resistance, Extended Spectrum beta-lactamase Productivity and Class 1 Integrons in Escherichia coli from Healthy Swine. J Food Protect 78(8):1442-50.

  9. Changkwanyeun R, Usui M, Kongsoi S, Yokoyama K, Kim H, Suthienkul O, Changkaew C, Nakajima C, Tamura Y, Suzuki Y. (2015) Characterization of Campylobacter jejuni DNA gyrase as the target of quinolones. J Infect Chemother 21:406-9.

  10. Usami O, Endo S, Inomata S, Nakajima C, Kanamori H, Hirakata Y, Uchiyama B, Kaku M, Suzuki Y, Hattori T. (2015) A case of Manila type Mycobacterium tuberculosis infection in Japan. Clinical Case Report 3:622-5.

  11. Ogawa H, Koizumi N, Ohnuma A, Mutemwa A, Hang'ombe BM, Mweene AS, Takada A, Sugimoto C, Suzuki Y, Kida H, Sawa H. (2015) Molecular epidemiology of pathogenic Leptospira spp. in the straw-colored fruit bat (Eidolon helvum) migrating to Zambia from the Democratic Republic of Congo. Infect Genet Evol 32:143-7.

  12. Mwikuma  G, Kwenda, Hang’ombe M B, Simulundu  E, Kaile  T, Nzala  S, Siziya  S, Suzuki  Y. (2015) Molecular identification of non-tuberculous mycobacteria isolated from clinical specimens in Zambia. Annals Clin Microb Antimicrob 14:1.


Review articles/Book/Text: 3

(*Corresponding author, ** Equal contribution)

  1. 鈴木定彦、田丸亜貴、松葉隆司、福島由華里、中島千絵 (2015)挿入配列を用いたRFLP型別、非結核性抗酸菌の基礎と臨床pp301-312 齋藤肇 監修 医療ジャーナル社 (in japanese)

  2. 鈴木定彦、中島千絵(2015)結核 -終わらない脅威とその対策ー 生命の科学 66(4):335-338 (in japanese)

  3. Ohatani K,   Suzuki Y,   Wakamiya N (2015)  New aspects of collectin functions.   Glycoscience: Biology and Medicine. Taniguchi, N., Endo,    T.,   Hart,   G.W.,   Seeberger,   P.H.,   Wong,   C.-H.  (Eds.). Springer Japan    pp1029-103.


Granted patents: 7

  1. Suzuki Y, Tahara H, Yamamoto K, Suzuki Y.      Protein substance having triple heliz structure and manufacturing method therefor.    Hong Kong Patent HK1163153

  2. Suzuki Y. Suzuki Y. Tahara H, Yamamoto K. Expression vector for Mass production of foreign gene-derived protein using animal cell and use thereof.China Patent ZL200980114565.X

  3. Suzuki Y, Tahara H, Yamamoto K, Suzuki Y. Protein substance having triple helix structure and manufacturing method therefor. EU Patent 2380979

  4. Tahara H, Suzuki Y, Yamamoto K, Kitahara Y, Suzuki Y. Expression vector for Mass production of foreign gene-derived protein using animal cell and use thereof. US Patent 9,096,878

  5. Tahara H, Suzuki Y, Yamamoto K, Kitahara Y, Suzuki Y. Expression vector for Mass production of foreign gene-derived protein using animal cell and use thereof. EU Patent 2385115

  6. 中島千絵、福島由華里、鈴木定彦.核酸増幅法およびその利用. 日本国特許5688702号 (in Japanse)

  7. 田原寛、鈴木祐介、山本啓一、北原譲、鈴木定彦.動物細胞を用いて外来遺伝子由来タンパク質を大量に生産するための発現ベクター、およびその利用. 日本国特許第5704753号 (in Japanse)


2010-2014: 80 publications

 *Corresponding author, ** Equal contribution, Faculty members are underlined. 

2014

Total: 28; Original articles: 16, Review articles/Book/Text: 2, Granted patents: 9, Applied patents: 1

Original articles with review

  1. Okubo T, Tosaka Y, Sato T, Usui M, Nakajima C, Suzuki Y, Imura S, Tamura Y. (2014) Bacterial Diversity in Sea Ice from the Southern Ocean and the Sea of Okhotsk. J Appl Environ Microbiol 2(6): 266-72.

  2. Mori K, Ohtani K, Jang S-J, Kim Y-U, Hwang I, Roy N, Matsuda Y, Suzuki Y, Wakamiya Y. (2014) Scavenger receptor CL-P1 mainly utilizes a collagen-like domain to uptake microbes and modified LDL. Biochimica et Biophysica Acta General Subjects 1840(12):3345-56.

  3. Jang S-J, Ohtani K, Fukuoh A, Mori, Yoshizaki T, Kitamoto N, Kim Y-U, Suzuki Y, Wakamiya N. (2014) Scavenger receptor CL-P1 mediates endocytosis by associating with AP-2μ2. Biochimica et Biophysica Acta General Subjects 1840:3226–37.

  4. Shiratori B, Leano PSA, Nakajima C, Chagan-Yasutan H, Niki T, Ashino Y, Suzuki Y, Telan EFO, Hattori T. (2014) Elevated OPN, IP-10 and neutrophilia in loop-mediated isothermal amplification confirmed tuberculosis patients. Mediators of Inflammation 2014:513263.

  5. Li D, Dong CB, Cui JY, Nakajima C, Zhang CL, Pan XL, Sun GX, Dai EY, Suzuki Y, Zhuang M, Ling H. (2014) Dominant modern sublineages and a new modern sublineage of Mycobacterium tuberculosis Beijing family clinical isolates in Heilongjiang Province, China. Infect Genet Evolu 27:294-9

  6. Changkaew K, Utrarachkij F, Siripanichgon K, Nakajima C, Suthienkul O, Suzuki Y. (2014) Characterization of Antibiotic Resistance in Escherichia coli Isolated from Shrimps and Their Environment. J Food Protect 77(8):1394-1401

  7. Ikebuchi R, Konnai S, Okagawa T, Yokoyama K, Nakajima C, Suzuki Y, Murata S, Ohashi K. (2014) Influence of PD-L1 cross-linking on cell death in PD-L1-expressing cell lines and bovine lymphocytes. Immunol 142(4):551-61.

  8. Nishimori A, Konnai S, Ikebuchi R, Okagawa T, Nakajima C, Suzuki Y, Mingala CN, Murata S, Ohashi K. Identification and characterization of bovine programmed death-ligand 2. Microbiol Immunol 58(7):388-97.

  9. Zhou M, Suganuma K, Ruttayaporn N, Nguyen T-T, Yamasaki S, Igarashi I, Kawazu S, Suzuki Y, Inoue N. (2014) Identification and characterization of a Trypanosoma congolense 46 kDa protein as a candidate serodiagnostic antigen. J Vet Med Sci 76(6):799-806.

  10. Itoh Y, Yoshida R, Shichinohe S, Higuchi M, Ishigaki H, Nakayama M, Pham VL, Ishida H, Kitano M, Arikata M, Kitagawa N, Mitsuishi Y, Ogasawara K, Tsuchiya H, Hiono T, Okamatsu M, Sakoda Y, Kida H, Ito M, Mai LQ, Kawaoka Y, Miyamoto H, Ishijima M, Igarashi M, Suzuki Y, Takada A. Protective Efficacy of Passive Immunization with Monoclonal Antibodies in Animal Models of H5N1 Highly Pathogenic Avian Influenza Virus Infection. PLoS Pathogen 10(6): e1004192

  11. Maekawa N, Konnai S, Ikebuchi R, Okagawa T, Adachi M, Takagi S, Kagawa Y, Nakajima C, Suzuki Y, Murata S, Ohashi K. Expression of PD-L1 on canine tumor cells and enhancement of IFN-γ production from tumor-infiltrating cells by PD-L1 blockade. PLoS One 9(6):e98415.

  12. Nishiuchi Y, Tamaru A, Suzuki Y, Kitada S, Maekura R, Tateishi Y, Niki M, Ogura H, Matsumoto S. (2014) Direct detection of Mycobacterium avium in environmental water and scale samples by loop-mediated isothermal amplification. J Water Health 12(2):211-219.

  13. Paudel S, Mikota SK, Nakajima C, Gairhe KP, Maharjan B, Thapa J, Poudel A, Shimozuru M, Suzuki Y, Tsubota T. (2014) Molecular characterization of Mycobacterium tuberculosis isolates from elephants of Nepal. Tuberculosis 94 (3): 287-292.

  14. Kim H, Hong Y, Shibayama K, Suzuki Y, Wakamiya N, Kim Y-U. Functional analysis of the receptor binding domain of SARS coronavirus S1 region and its monoclonal antibody. Genes Genom 36(3):387-397.

  15. Nguyen T-T, Zhou M, Ruttayaporn N, Nguyen QD, Nguyen VK, Goto Y, Suzuki Y, Kawazu S, Inoue N. (2014) Diagnostic value of the recombinant tandem repeat antigen TeGM6-4r for surra in water buffaloes. Vet Parasitol 201(1-2):18-23.

  16. Iwamoto T, Arikawa K, Nakajima C, Nakanishi N, Nishiuchi Y, Yoshida S, Tamaru A,Tamura Y, Hoshino Y, Yoo H, Park YK, Saito H, Suzuki Y. (2014) Intra-subspecies sequence variability of the MACPPE12 gene in Mycobacterium avium subsp. Hominissuis. Infect Genet Evolu 21:479-83


Review articles/Book/Text: 2

(*Corresponding author, ** Equal contribution)

  1. 鈴木定彦、中島千絵.(2014) 結核菌の薬剤耐性.化学療法の領域 30(1): 113-121 (in Japanse)

  2. 鈴木定彦、山口智之、金玄、横山和正、中島千絵 (2014) 結核研究からハンセン病研究へ:分子生物学的見地から.日本ハンセン病学会誌 83(3):131-137 (in Japanse)


Granted patents:  9

  1. Suzuki Y, Suzuki Y, Tahara H, Yamamoto K. Expression vector for Mass production of foreign gene-derived protein using animal cell and use thereof. US Patent 8653249

  2. Suzuki Y, Tahara H, Yamamoto K, Suzuki Y. Protein substance having triple helix structure and manufacturing method therefor. Australia Patent 2009331327

  3. Suzuki Y. Suzuki Y. Tahara H, Yamamoto K. Expression vector for Mass production of foreign gene-derived protein using animal cell and use thereof. China Patent 200980157244.8

  4. Suzuki Y. Suzuki Y. Tahara H, Yamamoto K. Expression vector for Mass production of foreign gene-derived protein using animal cell and use thereof. Australia Patent 2009218069

  5. Suzuki Y, Tahara H, Yamamoto K, Suzuki Y. Protein substance having triple helix structure and manufacturing method therefor. EU Patent EP09834882.4-1405

  6. Tahara H, Suzuki Y, Yamamoto K, Kitahara Y, Suzuki Y. Expression vector for Mass production of foreign gene-derived protein using animal cell and use thereof. Hong Kong (China) patent HK1163739

  7. 鈴木定彦, 田原寛, 鈴木祐介, 山本啓一. 動物細胞を用いて外来遺伝子由来タンパク質を大量に生産するための発現ベクター、およびその利用.日本国特許第5648912号 (in Japanse)

  8. 鈴木祐介, 山本啓一, 田原寛, 鈴木定彦. 三重螺旋構造を有するタンパク質、およびその製造方法.日本国特許5645187号 (in Japanse)

  9. Suzuki Y, Tahara H, Yamamoto K, Suzuki Y. Protein substance having triple helix structure and manufacturing method therefor. US Patent 8,470,555


Applied patents: 1

  1. 田村 豊、鈴木 定彦、中島千絵、臼井 優 薬剤感受性識別用マーカーを含むキットおよび方法.平成26年9月18日、特願2014-190530、出願人;関東化学株式会社、国立大学法人北海道大学、学校法人酪農学園 (in Japanse)


2013

Total: 6Original articles: 6

Original articles with review

  1. Mochabo KM, Zhou M, Suganuma K, Kawazu SI, Suzuki Y, Inoue N. (2013) Expression, immunolocalization and serodiagnostic value of Tc38630 protein from Trypanosoma congolense. Parasitol Res 112(9):3357-63.

  2. Ikebuchi R, Konnai S, Okagawa T, Yokoyama K, Nakajima C, Suzuki Y, Murata S, Ohashi K. (2013) Blockade of bovine PD-1 increases T cell function and inhibits bovine leukemia virus expression in B cells in vitro. Veterinary Research 44(1):59.

  3. Namangala B, Oparaocha E, Kajino K, Hayashida K, Moonga L, Inoue N, Suzuki Y, Sugimoto C. (2013) Preliminary investigation of trypanosomosis in exotic dog breeds from Zambia’s Luangwa and Zambezi valleys using LAMP. Am J Trop Med Hygine 89(1):116-118.

  4. Nakajima C, Tamaru A, Rahim Z, Poudel A, Maharjan B, Aye KS, Ling H, Hattori T, Iwamoto T, Fukushima Y, Suzuki H, Suzuki Y, Matsuba T. (2013) A simple multiplex PCR for the identification of Beijing family of Mycobacterium tuberculosis with a lineage-specific mutation in Rv0679c. J Clin Microbiol 51(7):2025-2032.

  5. Phetsuksiri B, Rudeeaneksin J, Srisungngam S, Bunchoo S, Roienthong D, Mukai T, Nakajima C, Hamada S, Suzuki Y. (2013) Applicability of in-house loop-mediated isothermal amplification for rapid identification of Mycobacterium tuberculosis complex grown on solid media. Jpn J Infect Dis 66 (3):249-251.

  6. Poudel A, Maharjan B, Nakajima C, Fukushima Y, Pandey BD, Beneke A, Suzuki Y. (2013) Characterization of extensively drug-resistant Mycobacterium tuberculosis in Nepal. Tuberculosis 93(1):84-88.


2012

Total: 24; Original articles: 21, Review articles/Book/Text: 1, Applied patents: 2

Original articles with review

  1. Hang'ombe BM, Munyeme M, Nakajima C, Fukushima Y, Suzuki H, Matandiko M, Ishii A, Mweene AS, Suzuki Y* (2012) Mycobacterium bovis infection at the interface between domestic and wild animals in Zambia. BMC Vet Res, 14:221

  2. Rahim Z, Nakajima C, Raqib R, Zaman K, Endtz HP, van der Zanden AGM, Suzuki Y* (2012) Molecular Mechanism of Rifampicin and Isoniazid Resistance in tuberculosis from Bangladesh. Tuberculosis, 92:529-34.

  3. Lee PS, Yoshida R, Ekiert DC, Sakai N, Suzuki Y, Takada A, Wilson IA (2012) Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor-binding site enhanced by avidity. Proc Natl Acad Sci USA, 109:17040-5.

  4. Yokoyama K, Kim H, Mukai T, Matsuoka M, Nakajima C, Suzuki Y* (2012) Impact of amino acid substitutions in B subunit of DNA gyrase in Mycobacterium leprae on fluoroquinolone resistance. PLoS Neglect Trop Dis, 6 (10):e1838.

  5. Tamaru A, Nakajima C, Wada T, Kawahara R, Maekura R, OzekiY, Ogura H, Kobayashi K, Suzuki Y, Matsumoto S (2012) Dominant Incidence of Multidrug and Extensively Drug-Resistant SpecificMycobacterium tuberculosis Clones in Osaka Prefecture, Japan. PLoS One, 7(8): e42505.

  6. Rahim Z, Momi SB, Saha SK, Zaman K, Uddin KN, Ashraf Jamil SNA, Nahar N, Azad Khan AK, Cooreman EAWD, Ahmed M, van der Zanden AGM, Nakazima C, Suzuki Y, Endtz HP (2012) Pulmonary tuberculosis in patients with diabetes mellitus in Bangladesh. Int J Tuberc Lung Dis. 16:1132-3.

  7. Rudeeaneksin J, Bunchoo S, Srisungngam S, Sawanpanyalert P, Chamnangrom S, Kamolwat A, Thanasripakdeekul P, Taniguchi T, Nakajima C, Suzuki Y*, Phetsuksiri B (2012) Simple and rapid identification of Mycobacterium tuberculosis in BACTEC MGIT960 cultures by in-house loop medicated isothermal amplification. Jpn J Infect Dis, 65:306-11.

  8. Bi A, Nakajima C, Fukushima Y, Tamaru A, Sugawara I, Kimura A, Kawahara R, Hu Z, Suzuki Y* (2012) A rapid loop-mediated isothermal amplification assay targeting hspX for the detection of Mycobacterium tuberculosis Jpn J Infect Dis, 65:247-51.

  9. Shiratori B, Zhang J, Usami O, Chagan-Yasutan H, Suzuki Y, Nakajima C, Uede T, Hattori T (2012) Quinolone-induced up-regulation of osteopontin gene promoter activity in human lung epithelial cell line A549. Agents Chemother, 56:2868-72.

  10. Koizumi N, Nakajima C, Harunari T, Tanikawa T, Tokiwa T, Uchimura E, Furuya T, Mingala C, Villanueva M, Ohnishi M, Suzuki Y (2012) A new loop-mediated isothermal amplification method for rapid, simple, and sensitive detection of Leptospira spp. in urine. J Clin Microbiol, 50:2072-4.

  11. Poudel A, Nakajima C, Fukushima Y, Suzuki H, Pandey BD, Maharjan B, Suzuki Y* (2012) Molecular Characterization of Multidrug-Resistant Mycobacterium tuberculosis Isolated in Nepal. Antimicrob Agents Chemother, 56:2831-2836.

  12. Iwamoto T, Nakajima C, Nishiuchi Y, Kato T, Yoshida S, Nakanishi N, Tamaru A, Tamura Y, Suzuki Y, Nasu M (2012) Genetic diversity of Mycobacterium avium subsp. hominissuis strains isolated from humans, pigs, and human living environment. Infect Genet Evolu, 12:846-52.

  13. Suzuki Y*, Nakajima C, Tamaru A, Kim H, Matsuba T, Saito H (2012) Sensitivities of ciprofloxacin-resistant Mycobacterium tuberculosis clinical isolates to fluoroquinolones: Role of mutant DNA gyrase subunits in drug resistance. Int J Antimicrob Agents, 39:435-9.

  14. Ohtani K, Suzuki Y and Wakamiya N (2012) Biological functions of the novel collectins CL-L1, CL-K1, and CL-P1. J Biomed Biotechnol, 2012:493945.

  15. Marzi A, Yoshida R, Miyamoto H, Ishijima M, Suzuki Y, Higuchi M, Matsuyama Y, Igarashi M, Nakayama E, Kuroda M, Saijo M, Feldmann F, Brining D, Feldmann H, Takada A (2012) Protective efficacy of neutralizing monoclonal antibodies in a nonhuman primate model of ebola hemorrhagic fever. PLoS ONE, 7:e36192.

  16. Siddiqi UR, Shiratori B, Chagan-Yasutan H, Ashino Y, Usuzawa M, Nakajima C, Suzuki Y, Saitoh H, Hattori T (2012) Distinct Clinical Features in Nontuberculous Mycobacterial Disease With or Without Latent Tuberculosis Infection. Tohoku J Exp Med, 226:313-9.

  17. Siddiqi UR, Leano PSA, Chagan HY, Shiratori B, Naitoh H, Ashino Y, Suzuki Y, Hattori T, Telan E (2012) Frequent detection of anti-tubercular-glycolipid IgG and IgA antibodies in the healthcare workers with latent tuberculosis infection in the Philippines. Clin Dev Immunol, 2012: 610707.

  18. Utrarachkij F, Pornraungwong S, Siripanichgon K, Nakajima C, Suzuki Y*, Suthienkul O (2012) Possible horizontal transmission of Salmonella via reusable egg trays in Thailand. Int J Food Microbiol, 157:73-8.

  19. Yokoyama K, Kim H, Mukai T, Matsuoka M, Nakajima C, Suzuki Y* (2012) Amino acid substitutions at position 95 in GyrA can add fluoroquinolone resistance to Mycobacterium leprae. Antimicrob Agents Chemother, 56:697-702.

  20. Kim H, Nakajima C, Kim Y-U, Yokoyama K, Suzuki Y* (2012) Influence of lineage specific amino acid dimorphism in GyrA on the fluoroquinolone resistance of Mycobacterium tuberculosis. Jpn J Infect Dis, 65:72-4.

  21. Yoshizaki T, Ohtani K, Motomura W, Jang S-J, Mori K, Kitamoto N, Yoshida I, Suzuki Y, Wakamiya N (2012) Comparison of human blood concentrations of Collectin Kidney 1 (CL-K1) and Mannan-binding lectin (MBL). J Biochem, 151:57-64.


Review articles/Book/Text: 1

  1. Shiratori B, Saitho H, Umme-Ruman S, Zhao J, Chagan-Yasutan H, Usuzawa M, NakajimaC, Suzuki Y, Hattori T. (2012) Immunological diagnosis of active and latent TB. Cardona P-J (eds.), Mycobacteriun tuberculosis/Book 1, Intech Open Access Publisher, Rijeka, Croatia, p353-78


Applied patents: 2

  1. 鈴木定彦、中島千絵、鈴木晴香、奥村英正、川瀬三雄、廣田寿一、丹羽孝介.標的ポリヌクレオチドの検出方法及びアレイ.PCT/JP2012/066167 (in Japanse)

  2. 中島 千絵、鈴木 定彦、福島 由華里.等温遺伝子増幅法とその応用. PCT/JP2012/56381 北海道大学 (in Japanse)


2011

Total: 12Original articles: 6, Review articles/Book/Text: 4, Applied patents: 2

Original articles with review

  1. Fukuda M, Ohtani K, Jang S-J, Yoshizaki T, Mori K, Motomura W, Yoshida I, Suzuki Y, Kohgo Y, Wakamiya N (2011) Molecular cloning and functional analysis of scavenger receptor zebrafish CL-P1. Biochim Biophys Acta-Gen Subj, 1810:1150-9.

  2. Koyama S, Ohtani K, Fukuzawa J, Yao N, Fukuda M, Jang SJ, Hasebe N, Kikuchi K, Itabe H, Yoshida I, Suzuki Y, Wakamiya N (2011) The induction of human CL-P1 expression in hypoxia/reoxygenation culture condition and rat CL-P1 after ischemic/reperfusion treatment. Biochim Biophys Acta-Gen Subj, 1810:836-42.

  3. Kim H, Nakajima C, Yokoyama K, Rahim Z, Kim Y-U, Oguri H, Suzuki Y* (2011) Impact of the E540V amino acid substitution in GyrB of Mycobacterium tuberculosis on Quinolone Resistance. Antimicrob Agents Chemother, 55:3661-7.

  4. Kim Y-U, Ohtani K, Mori K, Suzuki Y, Wakamiya N (2011) Gene Regulation Function of the Three Specificity Protein-1 (Sp1) within the Human Collectin Placenta-1 Proximal Promoter. Genes Genom, 33:273-81.

  5. Hang’ombe M B, Nakajima C, Ishii A, Fukushima Y, Munyeme M, Matandiko W, Mweene A S, Suzuki Y (2011) Rapid detection of Mycobacterium tuberculosis complex in Cattle and Lechwe (Kobus leche kafuensis) at the slaughter house. Vet Sci Dev, 1:e5.

  6. Wang J, Zhang C-L, Zhang L-Z, Ji B-Y, Liu Y, Shao Y-Z, Jiang S-L, Suzuki Y, Nakajima C, Fan C-L, Ma Y-P, Tian G-W, Hattori T, Ling H (2011) Genotypes and characteristics of clustering and drug-susceptibility of Mycobacterium tuberculosis isolates in Heilongjiang Province, China. J Clin Microbiol 49:1354-62.


Review articles/Book/Text

  1. 鈴木定彦、中島千絵、松葉隆司 (2011) 結核 最新医学 66:2689-96.

  2. 松葉隆司、甲斐政親、飯塚昌、鈴木定彦 (2011) 鳥取大学におけるバイオハザード対策用クラスIIキャビネットの維持管理とその発展途上国への応用.空気清浄 49:53-8

  3. 金玄、鈴木晴香、松岡正典、松葉隆司、横山和正、中島千絵、鈴木定彦 (2011) らい菌および結核菌のニューキノロン耐性獲得機構と耐性菌迅速鑑別法.日本ハンセン病学会誌.80:17-27.

  4. Suzuki Y, Nakajima C, Matsuba T (2011) Leprosy, M Makino, M Matsuoka, M. Goto and K hatano (ed.), Tokai University Press, Kanagawa, Japan. pp56-71


Applied patents: 

  1. 鈴木定彦、中島千絵、鈴木晴香、奥村英正、川瀬三雄、廣田寿一、丹羽孝介.標的ポリヌクレオチドの検出方法及びアレイ.平成23年6月28日、特願2011-143441、出願人;国立大学法人北海道大学、日本碍子株式会社 (in Japanese)

  2. 中島 千絵、鈴木 定彦、福島 由華里.核酸増幅方法およびその利用.平成23年3月14日、特願2011-55327、出願人;国立大学法人北海道大学 (in Japanese)


2010

Total: 10Original articles: 7, Review articles/Book/Text: 3

Original articles with review

  1. Rudeeaneksin J, Bunchoo S, Tanchai H, Sawanpanyalert P, Chamnangrom S, Kamolwat A, Thansripakdeekul P, Rienthong D, Phetsuksiri B, Suzuki Y. (2010) Rapid detection of Mycobacterium tuberculosis complex in sputum and in culture growth by LAMP test. J Health Sci 19(2): 300-10.

  2. Matsuoka M, Suzuki Y, Garcia I E, Fafutis-Morris M, Vargas-González A, Carreño-Martinez C, Fukushima Y, Nakajima C. (2010) Possible mode of emerging drug resistant leprosy cases revealed in Mexican samples’ analysis. Jpn J Infect Dis 63:412

  3. Fukasawa T, Oda N, Wada Y, Tamaru A, Fukushima Y, Nakajima C, Suzuki Y. (2010) A novel method for the purification of DNA by capturing nucleic acid and magnesium complexes on non-woven fabric filters under alkaline conditions for the gene diagnosis of tuberculosis by loop-mediated isothermal amplification (LAMP). Jpn J Infect Dis 63: 246-50.

  4. Ishihara K, Shimokubo N, Sakagami S, Ueno H, Muramatsu Y, Kadosawa T, Yanagisawa C, Hanaki H, Nakajima C, Suzuki Y, Tamura Y. (2010) Occurrence and molecular characteristics of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus pseudintermedius in an academic veterinary hospital. Appl Env Microbiol 76: 5165-74.

  5. Nakajima C, Rahim Z, Fukushima Y, Sugawara I, van der Zanden AGM, Tamaru A, Suzuki Y. (2010) Identification of Mycobacterium tuberculosis Clinical Isolates in Bangladesh by a Species Distinguishable Multiplex PCR. BMC Infect Dis 10:118.

  6. Okada K, Chantaroj S, Taniguchi T, Suzuki Y, Roobthaisong A, Puiprom O, Honda T, Sawanpanyalert P. (2010) A rapid, simple and sensitive detection of the toxigenic Vibrio cholerae in clinical samples by using Loop-mediated isothermal amplification method. Diagn Microb Infec Dis 66: 135-9.

  7. Uchiyama S, Suzuki Y, Ohtake K, Yokoyama M, Ota M, Aikawa S, Komatsu M, Sawada T, Kagami Y, Morishima Y, Fukui K. (2010) Development of Novel Humanized Anti-CD20 Antibodies Based on Affinity Constant and Epitope. Cancer Sci 101: 201-9.


Review articles/Book/Text

  1. 鈴木定彦、飯塚昌、大栗博毅、杉本千尋.(2010) 地球規模課題対応国際科学技術協力事業:結核及びトリパノソーマ症の診断法と治療薬開発.環境科学会誌.23:522-9.

  2. 松岡正典、鈴木定彦、牧野正直. (2010) DNAマイクロアレイを用いた薬剤耐性らい菌の簡易検出法の創出と、その開発途上国における有用性. 日本ハンセン病学会誌.79:257-62.

  3. 松葉隆司、中島千絵、鈴木定彦. (2010) 結核菌のエンベロープ構造と成分. 細菌学雑誌.65:355-368.


2005-2009: 48 publications

 * Corresponding author, ** Equal contribution, Faculty members are underlined.

2009

Total: 13Original articles: 6, Review articles/Book/Text: 3, Applied patents: 4

Original articles with review

  1. Yoda T, Suzuki Y, Yamazaki K, Sakon N, Kanki M, Kase T, Takahashi K, Inoue K. (2009) Applicability of a modified loop-mediated isothermal amplification kit for detecting Norovirus genogroups I and II. J. Med. Virol. 81: 2072-2078

  2. Poudel A, Pandey BD, Lekhak B, Rijal B, Sapkota BR, Suzuki Y. (2009) Clinical profiling and use of loop-mediated isothermal amplification assay for rapid detection of Mycobacterium tuberculosis from sputum. Kathmandu Univ. Med. J. 7:109-114.

  3. Adhikari BR, Pandy BD, Ghimire P, Shrestha B, Khadka M, Yoda T, Suzuki Y. (2009) Loop-Mediated Isothermal Amplification (LAMP) for the direct detection of human pulmonary infections with environmental (nontuberclosis) mycobacteria. Jpn. J. Infect. Dis. 62: 212-214

  4. Jang SJ, Ohtani K, Fukuoh A, Yoshizaki T, Fukuda M, Motomura W, Mori K, Fukuzawa J, Kitamoto N, Yoshida I, Suzuki Y, Wakamiya N. (2009) Scavenger receptor CL-P1 predominantly mediates zymosan phagocytosis by human vascular endothelial cells. J. Biol. Chem. 284:3956-3965

  5. Imamura, S., da Silva Vaz, I. Jr., Konnai, S., Yamada, S., Nakajima, C., Onuma, M. and Ohashi, K. (2009) Effect of vaccination with a recombinant metalloprotease from Haemaphysalis longicornis. Exp. Appl. Acarol. 48(4):345-358.

  6. Konnai, S., Nakajima, C., Imamura, S., Yamada, S., Nishikado, H., Kodama, M., Onuma, M. and Ohashi K. (2009) Suppression of cell proliferation and cytokine expression by HL-p36, a tick salivary gland-derived protein of Haemaphysalis longicornis. Immunology 126(2):209-219


Review articles/Book/Text:

  1. 大谷克城, 鈴木定彦, 若宮伸隆. (2009) 新規コレクチンの発見.旭川医科大学研究フォーラム 10: 2-12

  2. 鈴木定彦、中島千絵、福島由華里、田丸亜貴、松葉隆司.(2009) 超多剤耐性結核菌における耐性のメカニズムと耐性化防止対策 化学療法の領域 25: 612-620

  3. 鈴木定彦, 中島千絵,足立伸一. (2009) 内分泌撹乱物質とその生体影響.pp128-135 最新獣医公衆衛生学 (田村豊 編、緑書房).


Applied patents: 

  1. 樋口恵、鈴木定彦、高田礼人、喜田宏、吉田玲子、五十嵐学、宮本洋子. H5亜型インフルエンザウイルスに対する抗体およびその利用. 平成21年12月3日、特願2009-275367、科学技術振興機構、国立大学法人北海道大学

  2. Yasuhiko Suzuki, Keiichi Yamamoto, Yusuke Suzuki, Hiroshi Tahara. Expression vector for mass production of foreign gene-derived protein using animal cell and use thereof. 平成21年2月27日、PCT/JP2009/053682、国立大学法人北海道大学、扶桑薬品工業

  3. Yusuke Suzuki, Hiroshi Tahara, Keiichi Yamamoto, Yuzuru Kitahara,Yasuhiko Suzuki. Protein comprising triple-helix structure and manufacturing method thereof. 平成21年12月22日、PCT/JP2009/071327、国立大学法人北海道大学、扶桑薬品工

  4. Hiroshi Tahara, Yusuke Suzuki, Keiichi Yamamoto, Yuzuru Kitahara, Yasuhiko Suzuki. Expression vector for mass production of foreign gene-derived protein using animal cell and use thereof. 平成21年12月22日、PCT/JP2009/071326、国立大学法人北海道大学、扶桑薬品工業


2008

Total: 12; Original articles: 6, Review articles/Book/Text: 3, Applied patents: 3

Original articles with review

  1. Edagawa A, Kimura A, Doi H, Tanaka H, Tomioka K, Sakabe K, Nakajima C, Suzuki Y. (2008) Detection of culturable and nonculturable Legionella species from hot water systems of public buildings in Japan. J. Appl. Microbiol. 105:2104-2114

  2. Matsuoka M, Aye KS, Kyaw K, Tan EV, Balagon MV, Saunderson P, Makino M, Nakajima C, Suzuki Y. (2008) A novel method to simply detect mutations conferring drug resistance in Mycobacterium leprae based on a DNA microarray, and its applicability in developing countries. J. Med. Microbiol. 57: 1213-1219

  3. Pandey BD, Poudel A, Yoda T, Tamaru A, Oda N, Fukushima Y, Lekhak B, Risal B, Acharya B, Sapkota B, Nakajima C, Taniguchi T, Phetsuksiri B, Suzuki Y. (2008) Development of an in-house loop-mediated isothermal amplification (LAMP) assay for detection of Mycobacterium tuberculosis and evaluation in sputum samples of Nepalese patients. J. Med. Microbiol. 57: 439-43.

  4. Motomura W, Yoshizaki T, Ohtani K, Okumura T, Fukuda M, Fukuzawa J, Ogasawara M, Jang S-J, Nomura N, Yoshida Y, Suzuki Y, Kohgo Y, Wakamiya N. (2008) Immunolocalization of novel collectin CL-K1 in murine tissues. J. Histochem. Cytochem. 56: 243-52.

  5. Higuchi M, Matsuo A, Shingai M, Shida K, Ishii A, Funami K, Suzuki Y, Oshiumi H, Matsumoto M, Seya T. (2008) Combinational recognition of bacterial lipoproteins and peptidoglycan by chicken Toll-like receptor 2 subfamily. Dev. Comp. Immunol. 32:147-55.

  6. Imamura, S., Konnai, S., Vaz Ida, S., Yamada, S., Nakajima, C., Ito, Y., Tajima, T., Yasuda, J., Simuunza, M., Onuma, M. and Ohashi K. (2008) Effects of anti-tick cocktail vaccine against Rhipicephalus appendiculatus. Jpn. J. Vet. Res. 56(2):85-98.


Review articles/Book/Text:

  1. 鈴木定彦、中島千絵、福島由華里、田丸亜貴、松葉隆司.(2008) 結核の化学予防 臨床と微生物 25:669-675

  2. 鈴木定彦, 大谷克城, 張成宰, 本村旦, 若宮伸隆. (2008) 新規コレクチン CL-L1, CL-P1, CL-K1 の構造と機能. 臨床検査 52: 861-869.

  3. 鈴木定彦, 中島千絵. (2008) 結核菌群リファンピシン耐性遺伝子同定検査.臨床検査項辞典 (櫻林郁之介他編、医歯薬出版) 分担執筆 p644-645.


Applied patents: 

  1. 田原寛, 山本啓一, 鈴木祐介, 鈴木定彦. 動物細胞を用いて外来遺伝子由来タンパク質を大量に生産するための発現ベクター、およびその利用.平成20年12月22日、特願 2008-325690、国立大学法人北海道大学、扶桑薬品工業

  2. 鈴木祐介, 山本啓一, 田原寛, 鈴木定彦. 三重螺旋構造を有するタンパク質、およびその製造方法.平成20年12月22日、特願 2008-325691、国立大学法人北海道大学、扶桑薬品工業

  3. 鈴木定彦, 田原寛, 鈴木祐介, 山本啓一. 動物細胞を用いて外来遺伝子タンパク質を大量に生産するための発現ベクター、およびその利用. 平成20年2月27日、特願 2008-046782、国立大学法人北海道大学、扶桑薬品工業


2007

Total: 12; Original articles: 7, Review articles/Book/Text: 3, Applied patents: 2

Original articles with review

  1. Tambe Y, Yoshioka-Yamashita A, Mukaisho K, Haraguchi S, Chano T, Isono T, Kawai T, Suzuki Y, Kushima R, Hattori T, Goto M, Yamada S, Kiso M, Saga Y, Inoue H. (2007) Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs. Carcinogenesis. 28:777-84.

  2. Yoda T, Suzuki Y, Yamazaki K, Sakon N, Kanki M, Aoyama I, Tsukamoto T. (2007) Evaluation and Application of Detecting Norovirus using Reverse Transcription Loop-Mediated Isothermal Amplification. J. Med. Virol. 79:326-334.

  3. Kawai T, Kase T, Suzuki Y, Eda S, Sakamoto T, Ohtani K, Wakamiya N. (2007) Anti-influenza A virus activities of mannan-binding lectins and bovine conglutinin. J. Veter. Med. Sci. 69: 221-224. (Equal contribution) (2007 Feb)

  4. Matsuba T, Suzuki Y, Tanaka Y. (2007) Association of the Rv0679c protein with lipids and carbohydrates in Mycobacterium tuberculosis/Mycobacterium bovis BCG. Arch. Microbiol. 187:297-311.

  5. Okamoto S, Tamaru A, Nakajima C, Nishimura K, Tanaka N, Tokuyama S, Suzuki Y, Ochi K. (2007) Loss of a conserved 7-methylguanosine modification in 16S rRNA confers streptomycin resistance in bacteria. Molec. Microbiol. 63:1096-1106.

  6. Nintasen R, Utrarachkij F, Siripanichgon K, Bhumiratana A, Suzuki Y, Suthienkul O. (2007) Enhancement of Legionella pneumophila Culture Isolation from Microenvironments by Macrophage Infectivity Potentiator (mip) Gene-Specific Nested Polymerase Chain Reaction. Microbiol. Immunol. 51:777-785.

  7. Shiratori I, Suzuki Y, Oshiumi H, Begum NA, Ebihara T, Matsumoto M, Hazeki K, Kodama K, Kashiwazaki Y, Seya T. (2007) Recombinant interleukin-12 and interleukin-18 antitumor therapy in a guinea-pig hepatoma cell implant model. Cancer Sci. 98:1936-42.


Review articles/Book/Text: 

  1. Suzuki Y, Ohtani K, Wakamiya N. (2007) The novel collectins, CL-L1, CL-P1 and CL-K1. COLLAGEN-RELATED LECTINS IN INNATE IMMUNITY Kilpatrick D. edd. Research Spotlight, KereLa, India. p85-101

  2. 大谷克城, 鈴木定彦, 若宮伸隆. (2007) ヒト胎盤コレクチン1. 臨床検査 51:1714-1718.

  3. 鈴木定彦 (2007) らい菌抗原とハンセン病の分子生物学. 総説現代ハンセン病医学 (牧野正直他編, 東海大学出版会) 分担執筆 p20-40


Applied patents: 

  1. 内山進, 福井希一, 鈴木定彦, 横山雅美, 臼田定和. 細胞膜表面抗原エピトープに対する抗体の作製法およびアッセイ法 WO 2006/109533. 特開 2007-44035.

  2. 内山進, 福井希一, 鈴木定彦. 細胞膜表面物質の結合部位解析方法. 特開 2007-309746.


2006

Total: 7Original articles: 4, Review articles/Book/Text: 3

Original articles with review

  1. Nakajima, C., Imamura, S., Konnai, S., Yamada, S., Nishikado, H., Ohashi, K. and Onuma, M. (2006) A novel thrombin inhibitor identified from Haemaphysalis longicornis salivary gland. J. Vet. Med. Sci. 68:447-452.

  2. Konnai, S., Imamura, S., Nakajima, C., Witola, W.H., Yamada, S., Simuunza, M., Nambota, A., Yasuda, J., Ohashi, K. and Onuma, M. (2006) Acquisition and transmission of Theileria parva by vector tick, Rhipicephalus appendiculatus. Acta. Trop. 99:34-41.

  3. Sugiura W, Yoda T, Matsuba T, Tanaka Y, Suzuki Y. (2006) Expression and characterization of the genes encoding azoreductases from Bacillus subtilis and Geobacillus stearothermophilus. Biosci. Biotech. Biochem. 70: 1655-65.

  4. Keshi H, Sakamoto T, Kawai T, Ohtani K, Katoh T, Jang SJ, Motomura W, Yoshizaki T, Fukuda M, Koyama S, Fukuzawa J, Fukuoh A, Yoshida I, Suzuki Y, Wakamiya N. (2006) Identification and characterization of a novel human collectin CL-K1. Microbiol. Immunol. 50:1001-1013.


Review articles/Book/Text: 

  1. 大谷克城, 鈴木定彦, 若宮伸隆. (2006) コレクチンとその免疫応答における役割. 臨床免疫 45: 266-274.

  2. 鈴木定彦, 松岡正典. (2006) DNAマイクロアレイを用いた Mycobacterium leprae の迅速薬剤感受性試験法. 日本ハンセン病学会誌 75: 271-277.

  3. 鈴木定彦, 田丸亜貴, 中島千絵, 西原みづき, 福島由華里, 松葉隆司. (2006) 多剤耐性結核菌検出法の進歩. 化学療法の領域 22: 1705-1713.


2005

Total: 4; Original articles: 4

Original articles with review

  1. Matsumoto H*, Adachi S, Suzuki Y. (2005) Bisphenol A in ambient air particulates responsible for the proliferation of MCF-7 human breast cancer cells and Its concentration changes over 6 months. Arch. Environ. Contam. Toxicol. 48: 459-66.

  2. 松本比佐志*, 足立伸一, 鈴木定彦. (2005) 紫外線吸収剤及びその関連化合物によるエストロゲン様作用. 薬学雑誌 125: 643-652.

  3. 足立伸一*, 山本康次, 織田肇, 小野芳朗, 鈴木定彦. (2005) 新しいアッセイ用哺乳類細胞(CHOOSER)を用いた簡便,高感度で再現性の良いエストロゲン様活性測定方法の開発. 水環境学会誌 125: 451-456.

  4. Kumai Y, Suzuki Y, Tanaka Y, Shima K, Bharda RK, Yamasaki S, Kuroda K, Endo G*. (2005) Characterization of multidrug-resistance phenotypes and genotypes of Escherichia coli strains isolated from swine from an abattoir in Osaka, Japan. Epidemiol Infect. 133: 59-70.


1983-2004: 115 publications

 * Corresponding author, ** Equal contribution, Faculty members are underlined.

Total: 115Original articles: 75, Review articles/Book/Text: 32, Granted patents: 1, Applied patents: 7

  1. Kimura A, Suzuki Y, Matsui T. (2004) Identification of the Cryptosporidium isolate from chickens in Japan by sequence analyses. J Vet Med Sci. 66: 879-81.

  2. Ohmori H, Makita Y, Funamizu M, Chiba S, Ohtani K, Suzuki Y, Wakamiya N, Hata A. (2003) Haplotype analysis of the human collectin placenta 1 (hCL-P1) gene. J. Hum. Genet. 48: 82-5.

  3. Yoda T, Suzuki Y, Terano Y, Yamazaki K, Sakon N, Kuzuguchi T, Oda H, Tsukamoto T. (2003) Precise characterization of norovirus (Norwalk-like virus)-specific monoclonal antibodies with broad reactivity. J. Clin. Microbiol. 41: 2367-71.

  4. Suzuki K, Suzuki Y, Kitamura S. (2003) Cloning and expression of a UDP-glucuronic acid decarboxylase gene in rice. J Exp Bot. 54: 1997-9.

  5. Agdamag DMD, Kageyama S, Solante R, Espantaleon AS, Sangco JCE, Suzuki Y. (2003) Characterization of clinical isolates of Mycobacterium tuberculosis resistant to drugs and detection of rpoB mutation in multidrug-resistant tuberculosis in the Philippines. Int J Tuberc Lung Dis. 7: 1104-8.

  6. 吉川陽子, 市原竜生, 鈴木定彦. (2003) DNAマイクロアレイを用いた臨床分離結核菌の薬剤耐性判定. 臨床微生物迅速診断研究会誌 14: 45-50.

  7. Suzuki Y, Suzuki A, Tamaru A, Katsukawa C, Oda H. (2002) Rapid detection of pyrazinamide resistant Mycobacterium tuberculosis by PCR based in vitro system. J. Clin. Microbiol. 40: 501-7.

  8. Zhao H, Wakamiya N, Suzuki Y, Hamonko MT, Stahl GL. (2002) Identification of human mannose binding lectin (MBL) recognition sites for novel inhibitory antibodies. Hybrid Hybridomics. 21: 25-36.

  9. Kawai T, Suzuki Y, Yamashita A, Inoue H. (2002) Isolation of a novel mouse variant of the drs tumor suppressor gene. Cancer Lett. 183: 79-86.

  10. Kawai T, Suzuki Y, Eda S, Kase T, Ohtani K, Sakai Y, Keshi H, Fukuoh A, Sakamoto T, Nozaki M, Copeland NG, Jenkins NA, Wakamiya N. (2002) Molecular cloning of mouse Collectin Liver 1. Biosci. Biotechnol. Biochem. 66: 2134-45.

  11. Shimada T, Inoue K, Suzuki Y, Kawai T, Azuma E, Nakajima T, Shindo M, Kurose K, Sugie A, Yamagishi Y, Fujii-Kuriyama Y, Hashimoto M. (2002) Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice. Carcinogenesis. 23: 1199-1207.

  12. Hakozaki Y, Yoshiba M, Sekiyama K, Seike E, Iwamoto J, Mitani K, Mine M, Morizane T, Ohtani K, Suzuki Y, Wakamiya N. (2002) Mannose-binding lectin and the prognosis of fulminant hepatic failure caused by HBV infection. Liver 22: 29-34.

  13. Ruhul A, Suzuki Y, Takatorige T, Tatara K, Shirakura R. (2001) Usefulness of self ligation mediated polymerase chain reaction: a rapid method for fingerprinting in molecular epidemiology of tuberculosis. Kekkaku 76: 9-18.

  14. Suzuki Y, Yoda T, Ruhul A, Sugiura W. (2001) Molecular cloning and characterization of the gene coding for azoreductase from Bacillus sp. OY1-2 isolated from soil. J. Biol. Chem. 276: 9059-65.

  15. Tsuji S, Uehori J, Matsumoto M, Suzuki Y, Matsuhisa A, Toyoshima K, Seya T. (2001) Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell-wall. J. Biol. Chem. 276: 23456-63.

  16. Vorup-Jensen T, Sorensen ES, Jensen UB, Schwaeble W, Kawasaki T, Ma Y, Uemura K, Wakamiya N, Suzuki Y, Jensen TG, Takahashi K, Ezekowitz RA, Thiel S, Jensenius JC. (2001) Recombinant expression of human mannan-binding lectin. Int Immunopharmacol 1: 677-87.

  17. Tsutsumi A, Sasaki K, Wakamiya N, Ichikawa K, Atsumi T, Ohtani K, Suzuki Y, Koike T, Sumida T. (2001) Mannose-binding lectin gene: polymorphisms in Japanese patients with systemic lupus erythematosus, rheumatoid arthritis and Sjogren's syndrome. Genes Immun. 2: 99-104.

  18. Yoda T, Terano Y, Suzuki Y, Yamazaki K, Oishi I, Kuzuguchi T, Kawamoto H, Utagawa E, Takino K, Oda H, Shibata T. (2001) Characterization of Norwalk virus GI specific monoclonal antibodies generated against Escherichia coli

  19. expressed capsid protein and reactivity of two broadly reactive monoclonal antibodies generated against GII capsid to wards GI recombinant fragments. BMC Microbiol. 1: 24.

  20. Ohtani K, Suzuki Y, Eda S, Kawai T, Kase T, Keshi H, Sakai Y, Fukuoh A, Sakamoto T, Itabe H, Suzutani T, Ogasawara M, Yoshida I, Wakamiya N. (2001) The membrane type collectin CL-P1 is a scavenger receptor on vascular endothelial cells. J Biol. Chem. 276: 44222-8.

  21. Yoda T, Terano Y, Shimada A, Suzuki Y, Yamazaki K, Sakon N, Oishi I, Utagawa E, Okuno Y, Shibata T. (2000) Expression of recombinant Norwalk-like virus capsid proteins using a bacterial system and the development of its immunologic detection. J. Med. Virol. 60: 475-481.

  22. Kikkawa S, Shida K, Okamura H, Begum NA, Matsumoto M, Tsuji S, Nomura M, Suzuki Y, Toyoshima K, Seya T. (2000) A comparative analysis of the antigenic, structural, and functional properties of three different preparations of recombinant human interleukin-18. J. Interferon Cytokine Res. 20: 179-85.

  23. Sasaki K, Tsutsumi A, Wakamiya N, Ohtani K, Suzuki Y, Watanabe Y, Nakayama N, Koike T. (2000) Mannose-binding lectin polymorphisms in patients with hepatitis C virus infection. Scand J Gastroenterol 35: 960-5.

  24. Yoda T, Terano Y, Suzuki Y, Yamazaki K, Utagawa E, Shimada A, Matsuura S, Nakajima M, Shibata T. (2000) Characterization of monoclonal antibodies generated against Norwalk virus GII capsid protein expressed in Escherichia coli. Microbiol. Immunol. 44: 905-914.

  25. 芥子宏行, 大谷克城, 坂本隆志, 岸雄一郎, 荒木宏昌, 鈴木定彦, 若宮伸隆. (2000) 日本人におけるMBL(mannan-binding lectin)遺伝子変異と血中濃度. 医学のあゆみ 194: 957-958.

  26. Ohtani K, Suzuki Y, Eda S, Kawai T, Kase T, Keshi H, Sakai Y, Yamamoto S, Sakamoto T, Wakamiya N. (1999) High-level and effective production of human mannan-binding lectin (MBL) in Chinese hamster ovary (CHO) cells. J. Immunol Methods. 222: 135-144.

  27. Ohtani K, Suzuki Y, Eda S, Kawai T, Kase T, Yamazaki H, Shimada T, Keshi H, Sakai Y, Fukuoh A, Sakamoto T, Wakamiya N. (1999) Molecular cloning of a novel human collectin from liver (CL-L1) J. Biol. Chem. 274: 13681-13689.

  28. Kase T, Suzuki Y, Kawai T, Sakamoto T, Ohtani K, Eda S, Maeda A, Okuno Y, Kurimura T, Wakamiya N. (1999) Human mannan-binding lectin inhibits the infection of influenza A virus without complement. Immunology 97: 385-392.

  29. Kurita M, Matsumoto M, Tsuji S, Kawakami M, Suzuki Y, Hayashi H, Toyoshima K, Seya T. (1999) Antibody-independent classical complement pathway activation and homologous C3 deposition in xeroderma pigmentosum cell lines. Clin. Exp. Immunol. 116: 547-53.

  30. Shida K, Nomura M, Matsumoto M, Suzuki Y, Toyoshima K, Seya T. (1999) The 3'-UT of the ubiquitous mRNA of human CD46 confers selective suppression of protein production in murine cells. Eur J Immunol. 29: 3603-8.

  31. Yin Y, Suzuki Y, Makino M, Wu Q. (1999) Gene cloning and expression of Mycobacterium leprae alpha 2 antigen. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 21:62-68. (in Chinese)

  32. Yin Y, Suzuki Y, Makino M, Wu Q, Hou W. (1999) Preparation of recombinant alpha2 antigen of M. leprae in E. coli and the application for sero-diagnosis of leprosy. Chin. Med. Sci. J. 14:106.

  33. 田丸亜貴, 鈴木定彦. (1999) RFLP分析による結核小規模感染事例の疫学的研究. 結核 74: 555-561.

  34. Sakogawa, T., Kataoka, S., Okayama, A., Nakajima, C. and Hayama, T. (1999) A scientific note on in vitro experimental infection of American foulbrood in honeybee Apis mellifera L. Apidologie 30:75-76.

  35. Kawai T, Suzuki Y, Eda S, Ohtani K, Kase T, Sakamoto T, Uemura H, Wakamiya N. (1998) Molecular and biological characterization of rabbit mannan-binding protein. Glycobiology 8: 237-244.

  36. Suzuki Y, Katsukawa C, Tamaru A, Abe C, Makino M, Mizuguchi Y, Taniguchi H. (1998) Detection of kanamycin-resistant Mycobacterium tuberculosis by identifying mutations in the 16S rRNA gene. J Clin Microbiol. 36: 1220-1225.

  37. Hara T, Suzuki Y, Nakazawa T, Nishimura H, Nagasawa S, Nishiguchi M, Matsumoto M, Hatanaka M, Kitamura M, Seya T. (1998) Post-translational modification and intracellular localization of a splice product of CD46 cloned from human testis: role of the intracellular domains in O-glycosylation. Immunology 93: 546-555.

  38. Yamazaki H, Inoue K, Chiba K, Ozawa N, Kawai T, Suzuki Y, Goldstein JA, Guengerich FP, Shimada T. (1998) Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes. Biochem Pharmacol. 56: 243-251.

  39. Naito A, Suzuki Y, Azuma T. (1998) Regulation of promoter and intron enhancer activity in immunoglobulin heavy-chain genes during B-cell differentiation. Microbiol Immunol. 42: 399-405.

  40. Eda S, Suzuki Y, Kawai T, Ohtani K, Kase T, Sakamoto T, Wakamiya N. (1998) Characterization of truncated human mannan-binding protein (MBP) expressed in Escherichia coli. Biosci Biotechnol Biochem. 62: 1326-1331. Sakogawa, T., Kataoka, S., Kataoka, A., Nakajima, C. and Hayama, T. (1998) In vitro experimental infection of Paenibacillus larvae. Honeybee Science 19:145-148.

  41. Nakajima, C., Sakogawa, T., Okayama, A., Nakamura, A. and Hayama, T. (1998) Disposition of mirosamicin in honeybee hives. J. Vet. Pharmacol. Therapeut. Med. Sci. 21:269-273.

  42. Kawai T, Suzuki Y, Eda S, Ohtani K, Kase T, Fujinaga Y, Sakamoto T, Kurimura T, Wakamiya N. (1997) Cloning and characterization of a cDNA encoding bovine mannan-binding protein. Gene 186: 161-165.

  43. Katsukawa C, Tamaru A, Miyata Y, Abe C, Makino M, Suzuki Y. (1997) Characterization of the rpsL and rrs genes of streptomycin-resistant clinical isolates of Mycobacterium tuberculosis in Japan. J Appl Microbiol. 83: 634-640.

  44. Eda S, Suzuki Y, Kawai T, Ohtani K, Kase T, Fujinaga Y, Sakamoto T, Kurimura T, Wakamiya N. (1997) Structure of a truncated human surfactant protein D is less effective in agglutinating bacteria than the native structure and fails to inhibit haemagglutination by influenza A virus. Biochem J. 323: 393-399.

  45. Hashimoto C, Masuda H, Ayaki M, Suzuki Y, Uenaka A, Seya T, Miyoshi J, Takahashi K, Inui Y. (1997) Molecular cloning and sequence analysis of the cDNA for the mouse counterpart to adult hamster liver purified growth inhibitory factor. Biochem. Biophys. Acta. 1355: 205-208.

  46. Wakasugi T, Nagai T, Kapoor M, Sugita M, Ito M, Ito S, Tsudzuki J, Nakashima K, Tsudzuki T, Suzuki Y, Hamada A, Ohta T, Inamura A, Yoshinaga K, Sugiura M. (1997) Complete nucleotide sequence of the chloroplast genome from the green alga Chlorella vulgaris: The existence of genes possibly involved in chloroplast division. Proc. Natl. Acad. Sci. USA 94: 5967-5972.

  47. Suzuki Y, Eda S, Kawai T, Ohtani K, Kase T, Sakamoto T, Wakamiya N. (1997) Characterization of recombinant bovine conglutinin expressed in a mammalian cell. Biochem Biophys. Res. Commun. 238: 856-860.

  48. Nakajima, C., Okayama, A., Sakogawa, T., Nakamura, A. and Hayama, T. (1997) Disposition of ampicillin in honeybees and hives. J. Vet. Med. Sci. 59:765-767.

  49. Okayama, A., Sakogawa, T., Nakajima, C. and Hayama, T. (1997) Sporicidal activities of disinfectants on Paenibacillus larvae. J. Vet. Med. Sci. 59:953-954.

  50. Eda S, Suzuki Y, Kase T, Kawai T, Ohtani K, Sakamoto T, Kurimura T, Wakamiya N. (1996) Recombinant bovine conglutinin, lacking the N-terminal and collagenous domains, has less conglutination activity but is able to inhibit haemagglutination by influenza A virus. Biochem. J. 316: 43-48.

  51. Okayama, A., Sakogawa, T., Nakajima, C. and Hayama, T. (1996) Biological properties and antibiotic susceptibility of Bacillus larvae originated from American foulbrood of honeybee in Japan. J. Vet. Med. Sci. 58:439-441.

  52. Nakamura, A., Sugimoto, A., Okayama, A., Sakogawa, T. and Nakajima, C. (1996) Keeping honeybee in a flight room built in a semibarriered animal quarter. Honeybee Sci. 17: 61-66.

  53. Ohguchi, K., Takahara, H., Matsumoto, M., Nakajima, C. and Kido, Y. (1996) Residue analysis of spectinomycin in chicken and swine tissues by HPLC. 食衛誌 37:319-324.

  54. Suzuki Y, Katsukawa C, Inoue K, Yin Y, Tasaka H, Ueba N, Makino M. (1995) Mutations in rpoB gene of rifampicin resistant clinical isolates of Mycobacterium tuberculosis in Japan. Kansenshogaku Zasshi. 69: 413-419.

  55. Hara T, Suzuki Y, Semba T, Hatanaka M, Matsumoto M, Seya T. (1995) High expression of membrane cofactor protein of complement(CD46) in human leukaemia cell lines. Scand. J. Immunol. 42: 581-590.

  56. Motoyama N, Miwa T, Suzuki Y, Okada H, Azuma T. (1994) Comparison of somatic mutation frequency among immunoglobulin genes. J Exp Med. 179: 395-403.

  57. Inoue K, Inazawa J, Suzuki Y, Shimada T, Yamazaki H, Guengerich FP, Abe T. (1994) Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1. Jpn J Hum Genet. 39: 337-343.

  58. Itoh, S., Sone, M., Suzuki, K., Izumiya, K., Mochizuki, H., Tsutsui, T., Nakajima, C., Ogasa, A. and Nakahara, T. (1994) Induction of parturition in swine with prostaglandin F2α.analogue (Fenprostalene). Anim. Sci. Technol. 65:834-841.

  59. Suzuki Y, Yin Y, Makino M, Kurimura T, Wakamiya N. (1993) Cloning and sequencing of a cDNA coding for bovine conglutinin. Biochem Biophys Res Commun. 191: 335-342.

  60. Seki J, Wang X, Ota A, Suzuki Y, Sakato N, Fujio H. (1992) Inducibility of protein-reactive antibodies by peptide immunization: comparison of three epitope peptides of hen egg-white lysozyme. J Biochem. 111: 259-264.

  61. Nagata A, Suzuki Y, Igarashi M, Eguchi N, Toh H, Urade Y, Hayaishi O. (1991) Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins. Proc Natl Acad Sci USA 88: 4020-4024.

  62. Suzuki Y, Nagata A, Yamada T. (1991) Analysis of the promoter region in the rRNA operon from Mycobacterium bovis BCG. Antonie van Leeuwenhoek 60: 7-11.

  63. Sakato N, Rugdech P, Yoda T, Ota A, Zhao Y, Semma M, Suzuki Y, Fujio H. (1990) Activation of idiotype-specific CD4+ T-cell line: Cellular processing of exogenous self-immunoglobulin. Immunology. 71: 153-157.

  64. Urade Y, Nagata A, Suzuki Y, Fujii Y, Hayaishi O. (1989) Primary Structure of Rat Brain Prostaglandin D Synthetase Deduced from cDNA Sequence. J. Biol. Chem. 264: 1041-1045.

  65. Urade Y, Nagata A, Suzuki Y, Fujii Y, Hayaishi O (1989) Primary Structure of Rat Brain Prostaglandin D Synthetase Deduced from the cDNA Sequence. Annals of the New York Acad Sci, 559:491-493. doi:10.1111/j.1749-6632.1989.tb22652.

  66. Yoshinaga K, Ohta T, Suzuki Y, Sugiura M. (1988) Chlorella chloroplast DNA sequence containing a gene for the large subunit of ribulose-l,5-bisphosphate carboxylase/oxygenase and a part of a possible gene for the beta' subunit of RNA polymerase. Plant Mol. Biol. 10: 245-250.

  67. Suzuki Y, Yamada T. (1988) The nucleotide sequence of 16S rRNA gene from Streptomyces lividans TK21. Nucleic Acids Res. 16: 370.

  68. Suzuki Y, Yamada T. (1988) Study on rRNA Genes in Mycobacterium smegmatis. Microbiol. Immunol. 32: 1259-1262.

  69. Suzuki Y, Ono Y, Nagata A, Yamada T. (1988) Molecular Cloning and Characterization of an rRNA Operon in Streptomyces lividans TK21. J. Bacteriol. 170: 1631-1636.

  70. Suzuki Y, Nagata A, Ono Y, Yamada T. (1988) Complete nucleotide sequence of the 16S rRNA gene of Mycobacterium bovis BCG. J Bacteriol. 170: 2886-2889.

  71. 鈴木定彦, 山田毅. (1988) Mycobacterium phlei のリボソームRNA遺伝子の解析. 結核 63: 1-3.

  72. Suzuki Y, Mori T, Miyata Y, Yamada T. (1987) The number of ribosomal RNA genes in Mycobacterium lepraemurium. FEMS Microbiology Letters 44: 73-76.

  73. Suzuki Y, Yoshinaga K, Ono Y, Nagata A, Yamada T. (1987) Organization of rRNA Genes in Mycobacterium bovis BCG. J. Bacteriol. 169: 839-843.

  74. Yamada T, Nagata A, Ono Y, Suzuki Y, Yamanouchi T. (1985) Alteration of Ribosomes and RNA Polymerase in Drug-Resistant Clinical Isolates of Mycobacterium tuberculosis. Antimicrob. Agents and Chem other. 27: 921-924.

  75. Yoshinaga K, Suzuki Y. (1983) Rapid Preparation of Plasmid by Gel Permeation Chromatography on HW75S. Agric Biol Chem. 47: 919-920.


Review articles/Book/Text: 32

(*Corresponding author, ** Equal contribution)

  1. 鈴木定彦、中島千絵、福島由華里、田丸亜貴、松葉隆司.(2008) 結核の化学予防 臨床と微生物 25:669-675

  2. 鈴木定彦, 大谷克城, 張成宰, 本村旦, 若宮伸隆. (2008) 新規コレクチン CL-L1, CL-P1, CL-K1 の構造と機能. 臨床検査 52: 861-869.

  3. 鈴木定彦, 中島千絵. (2008) 結核菌群リファンピシン耐性遺伝子同定検査.臨床検査項辞典 (櫻林郁之介他編、医歯薬出版) 分担執筆 p644-645.

  4. Suzuki Y, Ohtani K, Wakamiya N. (2007) The novel collectins, CL-L1, CL-P1 and CL-K1. COLLAGEN-RELATED LECTINS IN INNATE IMMUNITY Kilpatrick D. edd. Research Spotlight, KereLa, India. p85-101

  5. 大谷克城, 鈴木定彦, 若宮伸隆. (2007) ヒト胎盤コレクチン1. 臨床検査 51:1714-1718.

  6. 鈴木定彦 (2007) らい菌抗原とハンセン病の分子生物学. 総説現代ハンセン病医学 (牧野正直他編, 東海大学出版会) 分担執筆 p20-40

  7. 大谷克城, 鈴木定彦, 若宮伸隆. (2006) コレクチンとその免疫応答における役割. 臨床免疫 45: 266-274.

  8. 鈴木定彦, 松岡正典. (2006) DNAマイクロアレイを用いた Mycobacterium leprae の迅速薬剤感受性試験法. 日本ハンセン病学会誌 75: 271-277.

  9. 鈴木定彦, 田丸亜貴, 中島千絵, 西原みづき, 福島由華里, 松葉隆司. (2006) 多剤耐性結核菌検出法の進歩. 化学療法の領域 22: 1705-1713.

  10. 鈴木定彦, 吉川陽子, 田丸亜貴, 田中吉紀. (2005) 薬剤耐性結核菌のDNAマイクロアレイ検出. 化学療法の領域 21: 334-342. (First author, Corresponding author)

  11. 鈴木定彦, 市原竜生, 田丸亜貴, Amin Ruhul, 勝川千尋, 牧野正直, 阿部千代治. (2005) DNAチップの開発 (松永是, ゲノム工学研究会監修, シーエムシー出版) 分担執筆.

  12. 若宮伸隆, 鈴木定彦. (2002) MBLその機能と生理学的意義. 臨床病理中四会誌 17: 2-12.

  13. 鈴木定彦, 田丸亜貴, 鈴木文, 勝川千尋. (2001) 結核菌の化学療法剤と薬剤耐性. 臨床と微生物 28: 35-41.

  14. 鈴木定彦, 田丸亜貴, 鈴木文, 勝川千尋. (2001) 結核菌の薬剤耐性. 感染症 31: 75-83.

  15. 若宮伸隆, 鈴木定彦. (2001) 膜型コレクチンは血管内皮に存在しスカベンジャーレセプター様の機能を持つ. 生化学 73: 205-208.

  16. 鈴木定彦, 若宮伸隆. (2001) 感染防御とコレクチンファミリー. Annual Review 免疫 2002: 217-225.

  17. 若宮伸隆, 鈴木定彦. (2000) 生体防御レクチンとしてのコレクチンファミリー. 蛋白質・核酸・酵素 45: 655-663.

  18. 鈴木定彦, 勝川千尋. (2000) 結核と非定型抗酸菌症. まこと 110 号.

  19. 鈴木定彦, 田丸亜貴, Amin Ruhul, 勝川千尋. (2000) 結核菌の薬剤耐性獲得機序の解析と迅速診断への展開. 防菌防黴 28: 561-573.

  20. 鈴木定彦, 市原竜生, 田丸亜貴, Amin Ruhul, 勝川千尋, 牧野正直, 阿部千代治. (2000) DNAチップによる結核菌の耐性診断. Bioindustry 17: 36-44

  21. 鈴木定彦, 田丸亜貴, 鈴木文, 勝川千尋. (2000) 結核菌の薬剤耐性と関与遺伝子. ファルマメディカ 18: 47-53.

  22. 長谷川好規, 阿部千代治, 飯沼由嗣, 鈴木定彦, 高橋光良, 水口康雄. (2000) 結核-分子遺伝学からのアプローチ. 結核 75: 725-728.

  23. 鈴木定彦, 市原竜生, 田丸亜貴, Amin Ruhul, 勝川千尋, 牧野正直, 阿部千代治. (2000) DNAチップ応用技術 (松永是, ゲノム工学研究会監修, シーエムシー出版) 分担執筆.

  24. 鈴木定彦, 田丸亜貴, Amin Ruhul, 勝川千尋. (1998) 結核菌の薬剤耐性検査;薬剤耐性に関与する遺伝子と迅速診断への応用の可能性. 臨床と微生物 25: 795-801

  25. 若宮伸隆, 鈴木定彦. (1997) レクチンによるウイルス感染制御. 臨床免疫 29: 508-513.

  26. 鈴木定彦. (1997) ハンセン病医学 分担執筆, 分子生物学の項目 (斎藤肇 他 編, 東海大学出版会) p19-37.

  27. 牧野正直, 鈴木定彦. (1996) 新内科学 (南江堂) 分担執筆, ハンセン病の項目.

  28. 鈴木定彦 免疫学辞典 初版 (1993) 分担執筆, 8 項目担当 (奥田研爾 他 編, 東京化学同人).

  29. 牧野正直, 鈴木定彦. (1992) 癩菌の細菌学. Jpn. J. Leprosy. 61: 73-87

  30. 鈴木定彦, 依田知子, 坂戸信夫. (1990) イデオタイプ特異性T細胞の活性化とその意義. 臨床免疫 22: 1087-1097

  31. 扇間昌規, 鈴木定彦, 藤尾啓, 坂戸信夫. (1989) 抗イデオタイプ抗体の抗腫瘍作用と癌免疫療法への応用. Biotherapy. 3: 1415-1429.

  32. 鈴木定彦, 山田毅. (1986) 抗酸菌における蛋白合成阻害剤への耐性獲得機構とその作用機序及びリボゾームの研究. 放線菌学会誌 49: 10-14.


Patents-granted: 1

  1. 鈴木定彦, 中村徹雄. 哺乳動物細胞用発現ベクター. 1998 特許第3582965号


Patents-applied: 7

  1. 鈴木定彦, 市原竜生, 佐藤記子. 結核菌のキノロン耐性の判定方法. 特開 2003-70478.

  2. 杉浦渉, 鈴木定彦, 淵上正晴, 横山正. アゾ染料還元分解酵素、アゾ染料還元分解酵素をコードする遺伝子、組換えベクター、形質転換体、アゾ染料還元分解酵素の製造方法、アゾ染料含有排水の処理方法、及び捺染方法. 特開 2002-65262.

  3. 柴田忠良, 鈴木定彦, 依田知子, 寺野由剛, 松浦司郎. ノルウォークウイルス(NV)を認識するモノクローナル抗体. 特開 2002-20399.

  4. 柴田忠良, 鈴木定彦, 依田知子, 松浦司郎, 寺野由剛. ノルウオークウイルスの免疫学的分析方法、感染症のスクリーニング方法及びスクリーニング用キット. 特開 2002-17397.

  5. 鈴木定彦, 西田道夫, 竹西壮一郎. 結核菌診断キット. 特開 2001-103981.

  6. 三宅伸一, 鈴木定彦, 坂戸信夫. アンチセンスRNAを発現するベクター. 1995 特開平 7-274967.

  7. 鈴木定彦, 松田久雄, 牧野正直, 栗田孝. PGL-1類似物質又は該物質に対する抗体の免疫学的測定方法. 1994 特開平 6-242116.