Ecology, evolution, and natural hosts of viruses
- Natural hosts of viruses and their perpetuation mechanism
- Global surveillance of avian influenza
To penetrate "VIRUSES"
ー From atomic/molecular elements to global ecology
About us国際疫学部門について
A cutting-edge laboratory exploring "VIRUSES"
In our laboratory, we are investigating a wide range of aspects in virology, from viral protein structures at the atomic and molecular level to virial ecology at the global level.
Specifically, we are investigating viruses and viral infectious diseases from a variety of perspectives, including the development of antiviral drugs, the mechanisms involved in infection at the cellular and individual levels, the elucidation of the natural hosts and transmission routes of zoonotic viruses, and field epidemiological studies.
Through this multifaceted approach, we continue research to protect human and animal health, eventually aiming to control viral zoonoses.
Newsお知らせ
- 08/22/2024 Our rapid diagnostic kit for Ebola virus disease has been approved in the Democratic Republic of the Congo.
- 01/27/2023 Members page is updated.
- 12/20/2021 Members page is updated.
- 08/03/2021 Publications and Research pages are updated.
- 04/05/2018 Members page is updated.
Research研究内容
Interaction between viral and host molecules
- Functional of viral surface glycoproteins and molecular basis of viral pathogenicity and host range
- Antibody-dependent enhancement of viral infection
- Computational analysis of virus/host molecular interactions
Structure and function of viral and host proteins
- In silico structure-function analysis of viral proteins
- Development of computer-aided methods to search for functional sites of viral protein
Prediction, prevention, diagnosis, and treatment of zoonotic diseases
- Antibody function in protective immunity against viral infection
- Drug screening for Ebola and Marburg diseases
- Rapid diagnosis tests of Ebola and Marburg diseases
- Structure-based design of antiviral molecules
Ecology, evolution, and natural hosts of viruses
1. Natural hosts of viruses and their perpetuation mechanism
>
Under Construction
2. Global surveillance of avian influenza
Under Construction
Interaction between viral and host molecules
1. Functional of viral surface glycoproteins and molecular basis of viral pathogenicity and host range
Under Construction
2. Antibody-dependent enhancement of viral infection
Under Construction
3. Computational analysis of virus/host molecular interactions
Under Construction
Structure and function of viral and host proteins
1. In silico structure-function analysis of viral proteins
Under Construction
2. Development of computer-aided methods to search for functional sites of viral protein
Under Construction
Prediction, prevention, diagnosis, and treatment of zoonotic diseases
1. Antibody function in protective immunity against viral infection
Under Construction
2. Drug screening for Ebola and Marburg diseases
Under Construction
3. Rapid diagnosis tests of Ebola and Marburg diseases
Under Construction
4. Structure-based design of antiviral molecules
Under Construction
Publicaitons研究業績
2024
- Munyeku-Bazitama Y, Saito T, Hattori T, Miyamoto H, Lombe BP, Mori-Kajihara A, Kajihara M, Muyembe-Tamfum J-J, Igarashi M, Park E-s, Morikawa S, Makiala-Mandanda S, Takada A (2024) Characterization of human tibrovirus envelope glycoproteins J Virol. 98(7): e0049924
- Fletcher P, Clancy CS, O'Donnell KL, Doratt BM, Malherbe DC, Rhoderick JF, Feldmann F, Hanley PW, Takada A, Messaoudi I, Marzi A (2024) Pathogenic differences of cynomolgus macaques after Tai Forest virus infection depend on the viral stock propagation PLoS Pathog. 20(6): e1012290
- Zhang Z, Takenaga T, Fehling SK, Igarashi M, Hirokawa T, Muramoto Y, Yamauchi K, Onishi C, Nakano M, Urata S, Groseth A, Strecker T, Noda T (2024) Hexestrol, an estrogen receptor agonist, inhibits Lassa virus entry J Virol. 98(7): e0071424
- Munyeku-Bazitama Y, Okitale-Talunda P, Hattori T, Saito T, Lombe BP, Miyamoto H, Mori-Kajihara A, Kajihara M, Nkoy AB, Twabela AT, Masumu J, Ahuka-Mundeke S, Muyembe-Tamfum JJ, Igarashi M, Park ES, Morikawa S, Makiala-Mandanda S, Takada A (2024) Seroprevalence of Bas-Congo virus in Mangala, Democratic Republic of the Congo: a population-based cross-sectional study Lancet Microbe. 5(6): e529-e537
- Tsukamoto Y, Igarashi M, Kato H. (2024) Targeting cap1 RNA methyltransferases as an antiviral strategy Cell Chem Biol. 31(1):86-99
2023
- Igarashi M, Hirokawa T, Takada A. (2023) Structural and Energetic Basis for Differential Binding of Ebola and Marburg Virus Glycoproteins to a Bat-Derived Niemann-Pick C1 Protein. J Infect Dis. 228(Supplement_7):S479-S487
- Mehedi M, Ricklefs S, Takada A, Sturdevant D, Porcella SF, Marzi A, Feldmann H (2023) RNA editing as a general trait of ebolaviruses J. Infect. Dis. 228(Suppl 7): S498-S507
- Fletcher P, Feldmann F, Takada A, Crossland NA, Hume AJ, Albariño C, Kemenesi G, Feldmann H, Mühlberger E, Marzi A (2023) Pathogenicity of Lloviu and Bombali viruses in IFNAR-/- mice J. Infect. Dis. 228(Suppl 7): S548-S553
- Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO (2023) The evolution and determinants of neutralization of potent head-binding antibodies against Ebola virus Cell Rep. 42(11):113366