発表論文

2004年以前の業績

澤 洋文

原著論文(英文)

2004

  1. Takahashi H, Sawa H, Hasegawa H, Nagashima K, Sata T, Kurata T: Topoisomerase I dissociates human immunodeficiency virus type 1 reverse transcriptase from genomic RNAs. Biochem Biophys Res Commun. 313: 1073-1078, 2004
  2. Ueno T, Tokunaga K, Sawa H, Maeda M, Chiba J, Kojima A, Hasegawa H, Shoya Y, Sata T, Kutrata T, Takahashi H: Nucleolin and the packaging signal, y promote the budding of human immunodeficiency virus type-1 (HIV-1). Microbiol Immunol 48: 111-118, 2004
  3. Matsumoto K, Minamitani T, Orba Y, Sato M, Sawa H, Ariga H: Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway. Exp Cell Res 297: 404-414, 2004
  4. Orba Y, Sawa H*, Iwata H, Tanaka S, Nagashima K: Inhibition of virus production in JC virus-infected cells by postinfection RNA interference. J Virol 78: 7270-7273, 2004 (* corresponding author)
  5. Qu Q, Sawa H*, Suzuki T, Semba S, Henmi C, Okada Y, Tsuda M, Tanaka S, Atwood WJ, Nagashima K: Nuclear entry mechanism of the human polyomavirus JC virus like particle: role of importins and the nuclear pore complex. J Biol Chem 279: 27735-27742, 2004 (* corresponding author)
  6. Minamitani T, Ikuta T, Saito Y, Takebe G, Sato M, Sawa H, Nishimura T, Nakamura F, Takahashi K, Ariga H, Matsumoto K: Modulation of collagen fibrillogenesis by tenascin-X and type VI collagen. Exp Cell Res 298: 305-15, 2004
  7. Chikai K, Ohnishi A, kato T, Ikeda J, Sawamura Y, Iwasaki Y, Itoh T, Sawa H, Nagashima K: Clinico-pathological features of piloymyxoid astrocytoma of the optic pathway. Acta Neuropathol 108: 109-114, 2004
  8. Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, Mochizuki N: A novel dynamin-associating molecule, formin-binding Protein 17, induces tubular membrane invaginations and participates in endocytosis. J Biol Chem 279: 40091-40099, 2004
  9. Matsumoto K, Sato T, Oka S, Orba Y, Sawa H, Kabayama K, Inokuchi Ji, Ariga H: Triglyceride accumulation and altered composition of triglyceride-associated fatty acids in the skin of tenascin-X-deficient mice. Genes Cells 9: 737-748, 2004
  10. Jin M, Sawa H*, Suzuki T, Shimizu K, Makino Y, Tanaka S, Nojima T, Fujioka Y, Asamoto M, Suko N, Nagashima K: Investigation of simian virus 40 large T antigen in 18 autopsied malignant mesothelioma patients in Japan. J Med Virol 74: 668-676, 2004 (* corresponding author)
  11. Tsuda M, Makino Y, Iwahara T, Nishihara H, Sawa H, Nagashima K, Hanafusa H, Tanaka S: Crk associates with ERM proteins and promotes cell motility toward hyaluronic acid. J Biol Chem 279: 46843-46850, 2004
  12. Aizawa H, Ohtani F, Furuta Y, Sawa H, Fukuda S: Variable patterns of varicella-zoster virus reactivation in Ramsay Hunt syndrome. J Med Virol 74: 355-360, 2004
  13. Furuta Y, Aizawa H, Ohtani F, Sawa H, Fukuda S: Varicella-zoster virus DNA level and facial paralysis in Ramsay Hunt syndrome. Ann Otol Rhinol Laryngol 113: 700-705, 2004
  14. Nagashima T, Chuma T, Mano Y, Goto Y-i, Hayashi KY, Minami N, Nishino I, Nonaka I, Takahashi T, Sawa H, Aoki M, Nagashima K: Dysferlinopathy associated with rigid spine syndrome. Neuropathology 24: 341-346, 2004

2003

  1. Yamamoto S, Furukawa H, Kitamoto T, Takamaru Y, Morita N, Yasuda M, Okada Y, Sawa H, Nagashima K: An atypical form of sporadic panencephalopathic Cleutzfeldt-Jakob disease in Japan. Neuropathol Appl Neurobiol 29: 77-80, 2003
  2. Higuchi E, Oridate N, Furuta Y, Suzuki S, Hatakeyama H, Sawa H, Sunayashiki-Kusazaki K, Yamazaki-k, Inuyama-Y, Fukuda S: Differentially expressed genes associated with cis-diammeinedichloroplatinum (II) resistance in head and neck cancer using differential display and cDNA microarray. Head Neck 25:187-93, 2003
  3. Ishikawa R, Kikuchi H, Jin M, Fujita M, Itoh T, Sawa H, Nagashima K: Desmoplastic malignant mesothelioma of the pleura: Autopsy reveals asbestos exposure. Pathol Int 53: 401-406, 2003
  4. Orba Y, Nishihara H, Sawa H, Itoo T, Shimizu M, Tanaka S, Nagashima K: Application of laser capture microdissection on cytological specimens for detection of immunoglobulin heavy chain gene rearrangement of malignant lymphoma. Cancer (Cancer Cytopathol) 99: 198-204, 2003
  5. Nagashima T, Mizutani Y, Kawahara H, Maguchi S, Terayama Y, Shinohara T, Orba Y, Chuma T, Mano Y, Itoh T, Sawa H, Sakai K, Motomura M, Nagashima K: Anti-Hu paraneoplastic syndrome presenting with brainstem-cerebellar symptoms and Lambert-Eaton myasthenic syndrome. Neuropathology 23: 230-238, 2003
  6. Endo S, Okada Y, Orba Y, Nishihara H, Tanaka S, Nagashima K, Sawa H*: JC virus (JCV) agnoprotein colocalizes with tubulin. J Neurovirol 9 (Suppl 1): 10-14, 2003 (*corresponding author)
  7. Shoya Y, Tokunaga T, Sawa H, Maeda M, Ueno T, Yoshikawa T, Sata T, Kurata T, Hall WW, Cullen BR, Takahashi H: Human topoisomerase I promotes HIV-1 proviral DNA synthesis: implications for the species specificity and cellular tropism of HIV-1 infection. Proc Natl Acad Sci USA 100: 8442-8447, 2003
  8. Ogita H, Kunimoto S, Kamioka Y, Sawa H, Matsuda M, Mochizuki N: EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. Circ Res 93: 23-31, 2003
  9. Watanabe I, Ross TM, Tamura Si, Ichinohe T, Ito S, Takahashi H, Sawa H, Chiba J, Kurata T, Sata T, Hasegawa H: Protection against influenza virus infection by intranasal administration of C3d-fused hemagglutinin. Vaccine 21: 4532-4538, 2003
  10. Ohnishi A, Sawa H, Tsuda M, Sawamura Y, Marukawa K, Iwasaki Y, Nagashima K: Expression of the oligodendroglial lineage-associated markers Olig1 and Olig2 in different types of human gliomas. J Neuropathol Exp Neurol 62: 1052-1059, 2003
  11. Ricciardiello L, Baglioni M, Giovannini C, Pariali M, Cenacchi G, Ripalti A, Landini MP, Sawa H, Nagashima K, Frisque RJ, Goel A, Boland CR, Tognon M, Roda E, Bazzoli F: Induction of Chromosomal Instability in Colonic Cells by the Human Polyomavirus JC Virus. Cancer Res 63:7256-7262, 2003
  12. Teramoto T, Kaneko H, Futano M, Sawa H, Nagashima K, Hirose Y, Kondo N: Progressive multifocal leukoencephalopathy in a patient with X-linked agammaglobulinemia. Scand J Infect Dis 35: 910-911, 2003

2002

  1. Okamoto T, Tanaka S, Stan AC., Koike T, Kase, Makita Z, Sawa H, Nagashima K: Advanced glycation end products induce angiogenesis in vivo. Microvasc Res 63: 186-195, 2002
  2. Kobayashi Y, Watanabe M, Okada Y, Sawa H, Takai H, Nakanishi M, Kawase Y, Suzuki H, Nagashima K, Ikeda K, Motoyama N: Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase λ-deficient mice: Possible implications for the pathogenesis of immotile cilia syndrome. Mol Cell Biol 22: 2769-2776, 2002
  3. Tsuda, M., Tanaka, S., Sawa, H., Hanafusa, H., Nagashima: Signalling adaptor protein v-Crk activates Rho and regulates cell motility in 3Y1 rat fibroblast cell line. Cell Growth Diff 13: 131-139, 2002
  4. Nishihara H, Tanaka S, Tsuda M., Oikawa S, Maeda M, Shimizu M, Shimoyama H, Tanigami A, Sawa H, Nagashima K: Molecular and immunohistochemical analysis of adaptor protein Crk in human cancers. Cancer Lett 180, 55-61, 2002
  5. Takahashi H, Sawa H, Hasegawa H, Sata T, Hall WW, Nagashima K, Kurata T: Reconstitution of cleavage of human immunodeficiency virus type-1 (HIV-1) RNAs. Biochem Biophys Res Commun 293: 1084-1091, 2002
  6. Matsumoto K, Sawa H, Sato M, Orba Y, Nagashima K, Ariga H: Distribution of extracellular matrix tenascin-X in sciatic nerves. Acta Neuropathol 104: 448-454, 2002
  7. Takahashi H, Sawa H, Hasegawa H, Shoya Y, Sata T, Hall WW, Nagashima K, Kurata T: Topoisomerase I and ATP activate cDNA synthesis of human immunodeficiency virus type-1 (HIV-1). Biochem Biophys Res Commun 294: 509-517, 2002
  8. Okada Y, Sawa H, Endo S, Orba Y, Umemura T, Nishihara H, Stan AC, Tanaka S, Nagashima K: Expression of JC virus (JCV) agnoprotein in progressive multifocal leukoencephalopathy (PML) brain. Acta Neuropathol 104: 130-136, 2002
  9. Makita N, Horie M, Nakamura T, Ai T, Otani H, Sawa H, Kitabatake A: Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation. Circulation 106: 1269-1274, 2002
  10. Hasegawa H, Tatsumi M, Ogawa-Goto K, Takahashi H, Iwasaki T, Kurata T, Sata T, Takeuchi T, Sheehy N, Sawa H, Nagashima K, Hall WW: Processing of the HTLV-II envelope precursor glycoprotein, gp63 by furin is essential for cell fusion activity. AIDS Res Hum Retroviruses 18: 1253-1260, 2002
  11. Nishihara H, Maeda M, Oda A, Tsuda M, Sawa H, Tanaka S, Nagashima K: DOCK2 associates with CrkL and regulates Rac1 in hematopoietic cells. Blood 100: 3968-3974, 2002
  12. Yoshida H, Okada Y, Kinoshita N, Hara H, Sasaki M, Sawa H, Nagashima K, Mak TW, Motoyama N: Differential requirement for Apaf1 and Bcl-XL in the regulation of programmed cell death during development. Cell Death Differ 9: 1273-1276, 2002
  13. Nishihara H, Maeda M, Tsuda M, Makino Y, Sawa H, Nagashima K, Tanaka S: DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription. Biochem Biophys Res Commun 296: 716-720, 2002
  14. Takai H, Naka K, Okada Y, Watanabe M, Harada N, Saito S, Anderson CW, Appella E, Nakanishi M, Suzuki H, Nagashima K, Sawa H, Ikeda K, Motoyama N: Chk2-deficient mice exhibit increased resistance to ionizing radiation and defective p53-mediated transcription. EMBO J 21: 5195-5205, 2002
  15. Komagome R, Sawa H*, Suzuki T, Suzuki Y, Tanaka S, Atwood WJ, Nagashima K: Oligosaccharides as receptors for JC virus. J Virol 76: 12992-13000, 2002 (* corresponding author)
  16. Takahashi H, Sawa H, Hasegawa H, Sata T, Hall WW, Kurata T: Binding and dissociation of human topoisomerase I with hair-pin loop RNAs: implications for the regulation of HIV-1 replication. Biochem Biophys Res Commun 297: 593-599, 2002

2001

  1. Nagai M, Tanaka S, Tsuda M, Endo S, Kato H, Sonobe H, Minami A, Hiraga H, Nishihara H, Sawa H, Nagashima K: Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin remodeling factor hBRM/hSNF2alpha. Proc Natl Acad Sci USA 98, 3843-3848, 2001
  2. Ohnishi J, Ohnishi E, Hirano W, Nakane D, Matsui H, Kimura A, Sawa H, Nakayama K, Shibuya H, Nagashima K, Takahashi T: Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development. Mol Endocrinol 15, 747-764, 2001
  3. Hayashi H, Endo S, Suzuki S, Tanaka S, Sawa H, Ozaki Y, Sawamura Y, Nagashima K: JC virus large T protein transforms rodent cells but is not involved in human medulloblastoma. Neuropathology 21: 129-137, 2001
  4. Zaman AK, Fujii S, Sawa H, Goto D, Ishimori N, Watano K, Kaneko T, Furumoto T, Sugawara T, Sakuma I, Kitabatake A, Sobel BE: Angiotensin-converting enzyme inhibition attenuates hypofibrinolysis and reduces cardiac perivascular fibrinolysis in genetically obese diabetic mice.  Circulation 103: 3123-3128, 2001
  5. Suzuki S, Sawa H*, Komagome R, Orba Y, Yamada M, Okada Y, Ishida Y, Nishihara H, Tanaka S, Nagashima K: Broad distribution of the JC virus receptor contrasts with a marked cellular restriction of virus replication. Virology 286: 100-112, 2001 (* corresponding author)
  6. Furuta Y, Ohtani F, Sawa H, Fukuda S, Inuyama Y: Quantitation of varicella-zoster virus DNA in patients with Ramsay Hunt syndrome and Zoster Sine Herpete. J Clin Microbiol 39: 2856-2859, 2001
  7. Kamimura E, UenoY, Tanaka S, Sawa H, Yoshioka M, Ueno K, Ishikawa R, Inoue T, Li X, Koyama T, Nagashima K: New rat model for attention deficit hyperactive disorder (ADHD). Comp Med 51: 245-251, 2001
  8. Okada Y, Endo S, Takahashi H, Sawa H, Umemura T, Nagashima K: Distribution and function of JCV agnoprotein. J Neurovirol 7: 302-306, 2001
  9. Tanaka S, Katano H, Tsukamoto K, Jin M, Oikawa S, Nishihara H, Sawa H, Sawada K, Shimizu M, Sata T, Fujioka Y, Nagashima K: HHV8-negative primary effusion lymphoma of the peritoneal cavity presenting with a distinct immunohistochemical phenotype. Pathol Int 51: 293-300, 2001
  10. Ohwatari R, Iwabuchi K, Iwabuchi C, Morohashi T, Sawa H, Hioki K, Kobayash iK, Fukuda S, Inuyama Y, Onoe K: Developmental and functional analyses of CD8+ NK1.1+ T cells in the class I restricted TCR transgenic mice. Cell Immunol. 213: 24-33, 2001
  11. Shirane M, Sawa H, Kobayashi Y, Nakano T, Shinkai Y, Nagashima K, Negishi I: Deficiency of phospholipase C-g1 impares renal development and hematopoiesis. Development 128: 5173-5180, 2001
  12. Nagashima T, Mori M, Fujimoto M, Nunomura M, Sakurai Y, Okada Y, Itoh T, Sawa H, Stan AC, Nagashima K: Adult T-cell lymphoma involving the leptomeninges associated with a spinal cord schwannoma. Neuropathology 21, 229-235, 2001
  13. Xie Z, Koyama T, Suzuki J, Fujii Y, Togashi H, Sawa H, Nagashima K: Coronary reperfusion following ischemia. Different expression of Bcl-2 and Bax proteins, and cardiomyocyte apoptosis. Jpn Heart J 42: 759-770, 2001
  14. Okamoto T, Tanaka S, Stan AC., Koike T, Kase, Makita Z, Sawa H, Nagashima K: Advanced glycation end products induce angiogenesis in vivo. Microvasc Res 63: 186-195, 2002

2000

  1. Xie Z, Koyama T, Abe K, Fujii Y, Sawa H, Nagashima K: Upregulation of p53 protein in rat heart subjected to a transient occlusion of the coronary artery followed by reperfusion. Jpn J Physiol 50: 159-162, 2000
  2. Okada Y, Sawa H*, Tanaka S, Takada A, Suzuki S, Hasegawa H, Umemura T, Fujisawa J-i, Tanaka Y, Hall WW, Nagashima1 K: Transcriptional activation of JC virus (JCV) by human T-lymphotropic virus type I (HTLV-I) tax protein in human neuronal cell lines. J Biol Chem, 275, 17016-17023, 2000 (* corresponding author)
  3. Yamashita S, Mochizuki N, Ohba Y, Tobiume M, Okada Y, Sawa H, Nagashima K, Matsuda M: CalDAG-GEFIII activation of Ras, R-Ras, and Rap1. J Biol Chem 275:25488-25493, 2000
  4. Hiroi Y, Chen R, Sawa H, Hosoda T, Kudoh S, Kobayashi Y, Aburatani H, Nagashima K, Nagai R, Yazaki Y, Medof ME, Komuro I: Cloning of murine glycosyl phosphatidylinositol anchor attachment protein, GPAA1. Am J Physiol Cell Physiol 279, C205-C212, 2000
  5. Shintaku M, Matsumoto R, Sawa H, Nagashima K: Infection with JC virus and possible dysplastic ganglion-like transformation of the cerebral cortical neurons in a case of progressive multifocal leukoencephalopathy. J Neuropathol Exp Neurol 59, 921-929, 2000
  6. Sato-Matsumura KC, Matsumura T, Nakamura H, Sawa H, Nagashima K, Koizumi H: Membranous expression of annexin I is enhanced by calcium and TPA in cultured human keratinocytes. Arch Dermatol Res 292, 496-499, 2000

~1999

  1. Kawaguchi H, Sawa H, Yasuda H: Effect of atrial natriuretic factor on angiotensin converting enzyme. J Mol Cell Cardiol 21: 959-961, 1989
  2. Kawaguchi H, Sawa H, Yasuda H: Endothelin stimulates angiotensin I to angiotensin II conversion in cultured pulmonary artery endothelial cells. J Mol Cell Cardiol 22: 893-842, 1990
  3. Kawaguchi H, Sawa H, Iizuka K, Yasuda H: Platelet-activating factor stimulates angiotensin converting enzyme activity. J Hypertens 8: 173-177, 1990
  4. Kawaguchi H, Sawa H, Yasuda H: Effect of atrial natriuretic factor on angiotensin converting enzyme. J Hypertens 8: 749-753, 1990
  5. Kawaguchi H, Sawa H, Yasuda H: Mechanism of increased angiotensin converting enzyme activity stimulated by platelet-activating factor. Biochim Biophys Acta 1052: 503-508, 1990
  6. Kawaguchi H, Shoki M, Sano H, Kudo T, Sawa H, Okamoto H, Sakata Y, Yasuda H: Phospholipid metabolism in cardiomyopathic hamster heart cells. Circ Res 69: 1015-1021, 1991
  7. Mochizuki N, Sawa H, Yasuda H, Shinohara T, Nagashima K, Yamaji N, Ohnuma N, Hall WW: Distribution of atrial natriuretic peptide in the conduction system and ventricular muscles of the human heart. Virchows Arch A Pathol Anat Histopathol 418: 9-16, 1991
  8. Kawaguchi H, Sawa H, Yasuda H: Effect of endothelin on angiotensin converting enzyme activity in cultured pulmonary artery endothelial cells. J Hypertens 9: 171-174, 1991
  9. Shoki M, Kawaguchi H, Okamoto H, Sano H, Sawa H, Kudo T, Hirao N, Sakata Y, Yasuda H: Phosphatidylinositol and inositolphosphatide metabolism in hypertrophied rat heart. Jpn Circ J 56:142-147, 1992
  10. Sawa H, Tokuchi F, Mochizuki N, Endo Y, Furuta Y, Shinohara T, Takada A, Kawaguchi H, Yasuda H, Nagashima K: Expression of the angiotensinogen gene and localization of its protein in the human heart. Circulation 86: 138-146, 1992
  11. Sawa H, Fujii S, Sobel BE: Augmented arterial wall expression of type-1 plasminogen activator inhibitor induced by thrombosis. Arterioscler Thromb 12: 1507-1515, 1992
  12. Fujii S, Sawa H, Sobel BE: Induction of endothelial cell expression of the plasminogen activator inhibitor type-1 gene by thrombosis in vivo. Circulation 86: 2000-2010, 1992
  13. Furuta Y, Takasu T, Asai T, Shinohara T, Sawa H, Nagashima K, Inuyama Y: Detection of human papillomavirus DNA in carcinomas of the nasal cavities and paranasal sinuses by polymerase chain reaction. Cancer 69: 353-357, 1992
  14. Kawaguchi H, Shoki M, Sano H, Kudo T, Sawa H, Okamoto H, Sakata Y, Yasuda H: The studies of cell damaging and cell growth factors which induce cardiomyopathy. Jpn Circ J 56: 1037-1044, 1992
  15. Kawaguchi H, Shoki M, Sano H, Kudo T, Sawa H, Mochizuki N, Okamoto H, Endo Y, Kitabatake A: Polyphosphoinositide metabolism in hypertrophic rat heart. J Mol Cell Cardiol 24: 1003-1010, 1992
  16. Sawa H, Sobel BE, Fujii S: Potentiation by hypercholesterolemia of the induction of aortic intramural synthesis of plasminogen activator inhibitor type-1 by endothelial injury. Circ Res 73: 671-680, 1993
  17. Fujii S, Sawa H, Sobel BE: Inhibition of endothelial cell expression of plasminogen activator inhibitor type-1 by gemfibrozil. Thromb Haemost 70: 642-647, 1993
  18. Sawa H, Sobel BE, Fujii S: Inhibition of type-1 plasminogen activator inhibitor production by antisense oligonucleotides in human vascular endothelial and smooth muscle cells. J Biol Chem 269: 14149-14152, 1994
  19. Sawa H, Kawaguchi H, Mochizuki N, Endo Y, Kudo T, Tokuchi F, Fujioka Y, Nagashima K, Kitabatake A: Distribution of angiotensinogen in diseased human hearts. Mol Cell Biochem 132: 15-23, 1994
  20. Nakayama K, Nakayama K-i, Negishi I, Kuida K, Sawa H, Loh DY: Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair,polycystic kidney disease, and lymphocytopenia. Proc Natl Acad Sci U S A 91: 3700-3704, 1994
  21. Sawa H, Lundgren C, Sobel BE, Fujii S: Increased intramural expression of plasminogen activator inhibitor type-1 after balloon injury: A potential progenitor of restenosis. J Am Coll Cardiol 24: 1742-1748, 1994
  22. Lundgren CL, Sawa H, Sobel BE, Fujii S: Modulation of expression of monocyte/macropharge plasminogen activator activity and its implications for attenuation of vasculopathy. Circulation 90: 1927-1934, 1994
  23. Nordt TK, Sawa H, Fujii S, Sobel BE: Induction of plasminogen activator inhibitor type-1 (PAI-1) by proinsulin and insulin in vivo. Circulation 91: 764-770, 1995
  24. Motoyama N, Wang F, Roth KA, Sawa H, Nakayama Ki, Nakayama K, Negishi I, Senju S, Zhang Q, Fujii S, Loh DY: Massiva cell death of post-mitotic immature lymphocytes in Bcl-x-deficient mice. Science 267: 1506-1510, 1995
  25. Mochizuki EY, Mochizuki N, Sawa H, Takada A, Okamoto H, Kawaguchi H, Nagashima K, Kitabatake A: Expression of renin and angiotensin converting enzyme in human hearts. Heart Vessels 10: 285-293, 1995
  26. Hasegawa S, Ritter JH, Patterson A, Ockner DM, Sawa H, Mohanakumar T, Cooper JD, Wick MR: Expression of intracellular and vascular cell adhesion molecules and class II major histocompatibility antigens in human lungs: luck of influence by conditions of organ preservation. J Heart Lung Transpl 14:897-905, 1995
  27. Sawa H, Lundgren CH, Brown SL, Fujii S: Dependence of human vascular cell surface proteolysis on expression of the urokinase receptor. J Thromb Thromboly 3: 331-336, 1996
  28. Okada H, Kawaguchi H, Kudo T, Sawa H, Okamoto H, Watanabe S, Urasawa K, Murakami T, Kitabatake A: Alteration of extracellular matrix in dilated cardiomyopathic hamster heart. Mol Cell Biochem 156: 9-15, 1996
  29. Shinohara K, Shinohara T, Mochizuki N, Mochizuki Y, Sawa H, Kohya T, Fujita M, Fujioka Y, Kitabatake A, Nagashima K: Expression of vascular endothelial growth factor associated with human myocardial infarction. Heart Vessels 11: 113-122, 1996
  30. Takahashi HR, Sawa H, Kuroda S, Saito H, Fujita M, Fujioka Y, Fukatsu R, Nagashima K: Pathologic processes leading to cerebral hemorrhage in amyloid angiopathy. Neuropathology 16: 99-105, 1996
  31. Matsumura SCK, Koizumi H, Matsumura T, Ohkawara A, Takasu T, Furuta Y, Sawa H, Nagashima K: Localization of annexin I (lipocortin I, p35) mRNA in normal and diseased human skin by in situ hybridization. Arch Dermatol Res 288:565-569, 1996
  32. Takahashi HR, Sawa H, Takada A, Kitabatake A, Nagashima K: Expression of beta-amyloid precursor protein mRNAs in the vascular smooth muscle cell of human brain. Neuropathology 17: 11-14, 1997
  33. Sasaki H, Kojima H, Yabe I, Tashiro K, Hamada T, Sawa H, Hiraga H, Nagashima K: Neuropathological and molecular studies of spinocerebellar ataxia type 6 (SCA6). Acta Neuropathol 95: 199-204, 1998
  34. Kobayashi Y, Sawa H, Akagi H, Itakura C, Fujioka Y, Nagashima K: Distributional pattern of apoptotic cells in rat cerebellar vermis experimentally induced by methylmercury intoxication. Neuropathology 18: 33-37, 1998
  35. Nordt TK, Sawa H, Fujii S, Bode C, Sobel BE: Augmentation of arterial endothelial cell expression of the plasminogen activator inhibitor type-1 (PAI-1) gene by proinsulin and insulin vivo. J Mol Cell Cardiol 30: 1535-1543, 1998
  36. Hiraga H, Nojima T, Abe S, Sawa H, Yamashiro K, Yamawaki S, Kaneda K, Nagashima K: Diagnosis of synovial sarcoma with the reverse transcriptase-polymerase chain reaction: analyses of 84 soft tissue and bone tumors. Diagn Mol Pathol 7: 102-110, 1998
  37. Kobayashi Y, Sawa H, Watanabe M, Furuoka H, Matsui T, Nagashima K: Calbindin D immunoreactivity and chronic lesions of rat cerebella in methylmercury chrolide intoxication. Neuropathology 18: 402-407, 1998
  38. Suzuki G, Sawa H, Kobayashi Y, Nakata Y, Nakagawa Ki, Uzawa A, Sakiyama H, Kakinuma S, Iwabuchi K, Nagashima K: Pertussis toxin-sensitive signal controls the trafficking of thymocytes across corticomedullary junction in the thymus. J Immunol 162: 5981-5985, 1999
  39. Ohba Y, Suzuki H, Hiraga H, Ito T, Sawa H, Nagai M, Satoh S, Iwaki H, Nagashima K: Melanotic peritoneal sarcomatosis originating from clear cell sarcoma. Pathol Int 49: 653-657, 1999

原著論文(和文)

  1. 澤 洋文:アンジオテンシノーゲンのヒト臓器における遺伝子の発現とその局在に関する研究。 北海道医学雑誌 65: 189-199, 1990
  2. 岡田 斉、安田 寿一、澤 洋文、藤田 美悧、藤岡  保範、 長嶋 和郎:繰り返す胸痛歴の後に発症した致死性不整脈。 北海道医学雑誌 66: 86-93, 1991
  3. 上村 明、馬場 顕介、原 豊道、四戸 力也、笹山 辰之、大平 浩司、須甲 憲明、吉田 和博、井上 幹朗、鈴木 章彦、伊藤 哲夫、牧野 吉倫、澤 洋文、長嶋 和郎:結節性紅斑を合併した膵内分泌腫瘍の1例。岩見沢市立総合病院医誌、29: 21-26, 2003
  4. 今村 栄次、山下 拓史、福原 敏行、澤 洋文、長嶋 和郎、桑原 正雄、時信 弘:高活性レトロウイルス療法により免疫再構築症候群をきたしたAIDSにともなう進行性多巣性白質脳症の1剖検例。臨床神経学47: 650-656, 2007

総説(英文)

  1. Nordt TK, Sawa H, Fujii S, Sobel BE, Kubler W: Regulation des plasminogenaktivvator-inhibitors typ-1 (PAI-1) durch proinsulin, proinsulin-spaltprodukte, und insulin in vitro und in vivo. In: Heinle H, Sculte H, Kaffarnik H (eds.) Arteriosklerose zerebraler gefaB9 9. Jahrestagung der Deutschen Gesellschaft fur Arterioskleroseforschung 1995, S. 151-158
  2. Nordt TK, Sawa H, Fujii S, Sobel BE, Kubler W: Hyperinsulinamie steigert die genetische expression von plasminogenaktivvator-inhibitors typ-1 (PAI-1) im arteriellen endothel in vivo. In: Heinle H, Sculte H, Kaffarnik H (eds.) Endokrine und zellbiologische aspekte der arteriosklerose 10. Jahrestagung der Deutschen Gesellschaft fur Arterioskleroseforschung 1996, S.76-82
  3. Nagashima K, Sawa H: Neurotoxicity at the cellular levels. In Takizawa Y, Osame M (eds) Understanding of Minamata disease. Methylmercury poisoning in Minamata and Niigata, Japan. Japan Public Health Association, 2001, 75-79.
  4. Sawa H, Komagome R: The JC virus-like particle overlay assay. In Lieberman PM (ed) Methods in Molecular Biology. DNA viruses, Methods and Protocols. Humana Press, Totowa, NJ 2005;292: 175-186
  5. Kasamatsu H, Nakanishi A, Liddington RC, Sawa H: Structural and Functional Studies of Polyomavirus Late Gene Products In Yoshida K (ed) Molecular Biology of Tumor Virus Gene Products. Research Signpost, Kerala, India (in press)

総説(和文)

  1. 澤 洋文、 望月 直樹、 川口 秀明、 安田 寿一、 長嶋 和郎: ヒト心室系におけるANPの局在。 心筋の構造と代謝 11: 717-731, 1988
  2. 澤 洋文、望月 直樹、 川口 秀明、 安田 寿一: アンジオテンシン変換酵素阻害薬は心肥大を退縮させるか? Therapeutic Reseach 10: 43-49, 1989
  3. 遠藤 由香、澤 洋文、 望月 直樹、得地 史郎、古田 康、篠原 敏也、川口 秀明、 安田 寿一、北畠 顕、 長嶋 和郎:アンジオテンシノーゲンのヒト心臓での発現 。 心筋の構造と代謝14: 429-434, 1991
  4. 川口 秀明、遠藤 由香、工藤 敏行、渡邊 正司、澤 洋文、岡田 斉、 望月 直樹、北畠 顕:レニン-アンジオテンシン系の変化と心不全の病態に及ぼす影響。 メビオ 12: 37-45, 1995
  5. 北畠 顕、澤 洋文:動脈硬化病変におけるplasminogen activator inhibitor type-1(PAI-1)の遺伝子発現機序について。 臨床成人病 25: 1332-1333, 1995
  6. 斎藤 泰史、澤 洋文、高橋 礼典、北畠 顕、長嶋 和郎:ヒト血管におけるamyloid precursor proteinの発現 -in situ hybridizationによるmRNAの検出-。 心筋の構造と代謝16: 141-145, 1996
  7. 澤 洋文:第3回 国際神経ウイルス学会に参加して。ウイルス 51: 113-118, 2001
  8. 大場 靖子、澤 洋文、長嶋 和郎:JC virusの分子神経病理学。脳と神経 54: 101-109, 2002
  9. 仙葉 慎吾、澤 洋文、長嶋 和郎:JCウイルスからみたグリアの生物科学。神経研究の進歩 46: 557-565, 2002
  10. 鈴木 忠樹、澤 洋文、長嶋 和郎:ヒトポリオーマウィルス・JC ウィルスとヒト腫瘍の発生。 医学のあゆみ 203: 245-247, 2002
  11. 澤 洋文:教室紹介。ウイルス 55: 331-333, 2005
  12. 澤 洋文、鈴木 忠樹、大場 靖子、寸田 祐嗣、長嶋 和郎:JCウイルスの最近の基礎的知見。BRAIN and NERVE 59: 101-108, 2007
  13. 鈴木 忠樹、長嶋 和郎、澤 洋文:進行性多巣性白質脳症 (PML):原因ウイルスと発病機構。 日本臨床 65: 1495-1500, 2007

木村 享史

原著論文(英文)

  1. Shirato, K., Kimura, T., Mizutani, T., Kariwa, H. and Takashima, I. Different chemokine expression in lethal and non-lethal murine West Nile virus infection. J. Med. Virol. 74:507-513, 2004.
  2. Watanabe, K., Kadosawa, T., Ishiguro, T., Takagi, S., Ochiai, K., Kimura, T., Okumura, M. and Fujinaga, T. Odontogenic cysts in three dogs: one odontogenic keratocyst and two dentigerous cysts. J. Vet. Med. Sci. 66:1167-1170, 2004.
  3. Tomioka, Y., Ochiai, K., Ohashi, K., Ono, E., Toyoda, T., Kimura, T. and Umemura, T. Genome sequence analysis of the avian retrovirus causing so-called fowl glioma and the promoter activity of the long termnal repeat. J. Gen. Virol. 85:647-652, 2004.
  4. Nakamura, K., Ochiai, K., Kadosawa, T., Kimura, T. and Umemura, T. Canine ganglioneuroblastoma in the oral mucosa. J. Comp. Pathol. 130:205-208, 2004.
  5. Kimura, T., Hasebe, R., Mukaiya, R., Ochiai, K., Wada, R. and Umemura, T. Decreased expression of equine herpesvirus-1 early and late genes in the placenta of naturally aborted equine fetuses. J. Comp. Pathol. 130:41-47, 2004.
  6. Toyoda, T., Ochiai, K., Komatsu, M., Kimura, T. and Umemura, T. Nutritional secondary hyperparathyroidism and osteodystrophia fibrosa in a Hodgson’s hawk-eagle (Spizaetus nipalensis). Avian Pathol. 33:9-12, 2004.
  7. Matsuda, K., Park, C. H., Sunden, Y., Kimura, T., Ochiai, K., Kida, H. and Umemura T. The vagus nerve is one route of transneural invasion for intranasally inoculated influenza A virus in mice. Vet. Pathol. 41:101-107, 2004.
  8. Tomioka, Y., Ochiai, K., Ohashi, K., Kimura, T. and Umemura, T. In ovo infection with an avian leukosis virus causing fowl glioma: viral distribution and pathogenesis. Avian Pathol. 32:617-24, 2003.
  9. Sunden, Y., Park, C. H., Matsuda, K., Anagawa, A., Kimura, T., Ochiai, K., Kida, H. and Umemura, T. The effect of antipyretics on influenza virus encephalitis in mice and chicks. J. Vet. Med. Sci. 65:1185-1188, 2003.
  10. Park, C.H., Matsuda, K., Sunden, Y., Ninomiya, A., Takada, A., Ito, H., Kimura, T., Ochiai, K., Kida, H. and Umemura, T. Persistence of viral RNA segments in the central nervous system of mice after recovery from acute influenza A virus infection. Vet. Microbiol. 97:259-268, 2003.
  11. Kim, H-O, Matsuda, K., Kimura, T., Ochiai, K., Yazawa, H., Itakura, C. and Umemura, T. Impaired myelinogenesis and early maturation of oligodendrocytes in black tremor hamster with central nervous system myelin deficiency. J. Toxicol. Pathol. 16:209-213, 2003.
  12. Kim, H-O, Kimura, T., Ochiai, K., Yazawa, H., Itakura, C. and Umemura, T. Sustained hypomyelination and high serum thyroid hormone in aged black tremor hamster. Jpn. J. Vet. Res. 51:113-120, 2003.
  13. Mizutani, T., Kobayashi, M., Eshita, Y., Shirato, K., Kimura, T., Ako, Y., Miyoshi, H., Takasaki, T., Kurane, I., Kariwa, H., Umemura, T. and Takashima, I. Involvement of the JNK-like protein of the Aedes albopictus mosquito cell line, C6/36, in phagocytosis, endocytosis and infection of West Nile virus. Insect Mol. Biol. 12:491-499, 2003.
  14. Kimura, T. and Griffin, D. E. Extensive immune-mediated hippocampal damage in mice surviving infection with neuroadapted Sindbis virus. Virology 311:28-39, 2003.
  15. Hasebe, R., Kimura, T., Nakamura, K., Okazaki, K., Ochiai, K., Wada, R. and Umemura, T. Passage of equine herpesvirus-1 in suckling mouse brain enhances extraneural virus growth and subsequent hematogenous neuroinvasion. J. Vet. Med. Sci. 64:907-912, 2002.
  16. Kobayashi, A., Katagiri, S., Kimura, T., Ochiai, K. and Umemura, T. Steroid hormones do not reactivate Neospora caninum in ovariectomized mice. J. Vet. Med. Sci. 64:773-777, 2002.
  17. Hasebe, R., Kimura, T., Sato, E., Okazaki, K., Ochiai, K., Wada, R. and Umemura, T. Equine herpesvirus-1-induced encephalomyelitis in mice: a comparative study of neuroadapted virus and its parent strain. J. Comp. Pathol. 127:118-125, 2002.
  18. Park, C. H., Ishinaka, M., Takada, A., Kida, H., Kimura, T., Ochiai, K. and Umemura, T. The invasion routes of neurovirulent A/Hong Kong/483/97 (H5N1) influenza virus into the central nervous system after respiratory infection in mice. Arch. Virol. 147:1425-1436, 2002.
  19. Kimura, T., Mitsui, I., Okada, Y., Furuya, T., Ochiai, K., Umemura, T. and Itakura, C. Distribution of rabbit haemorrhagic disease virus RNA in experimentally infected rabbits. J. Comp. Pathol. 124:134-141, 2001.
  20. Thach, D. C., Kimura, T. and Griffin, D. E. Differences between C57BL/6 and BALB/cBy mice in mortality and virus replication after intranasal infection with neuroadapted Sindbis virus. J. Virol. 74:6156-6161, 2000.
  21. Kimura, T. and Griffin, D. E. The role of CD8+ T cells and major histocompatibility complex class I expression in the central nervous system of mice infected with neurovirulent Sindbis virus. J. Virol. 74:6117-6125, 2000.
  22. Mukaiya, R., Kimura, T., Ochiai, K., Umemura, T. Demonstration of equine herpesvirus-1 gene expression in the placental trophoblasts of naturally aborted equine fetuses. J. Comp. Pathol. 123:119-125, 2000.
  23. Watanabe, T., Shinohara, N., Sazawa, A., Kobayashi, Y., Ogiso, Y., Kimura, T., Takiguchi, M., Yasuda, J., Hashimoto, A., Koyanagi, T. and Kuzumaki, N. Suppressive effects of dominant negative ras mutant N116Y on transformed phenotypes of human bladder cancer cells. Cancer Lett. 149:195-202, 2000.
  24. Nishino, Y., Funaba, M., Fukushima, R., Mizutani, T., Kimura, T., Iizuka, R., Hirami, H. and Hara, M. Borna disease virus infection in domestic cats: evaluation by RNA and antibody detection. J. Vet. Med. Sci. 61:1167-70, 1999.
  25. Asano, K., Murakami, M., Endo, D., Kimura, T. and Fujinaga, T. Complementary DNA cloning, tissue distribution, and synthesis of canine brain natriuretic peptide. Am. J. Vet. Res. 60:860-864, 1999.
  26. Handharyani, E., Ochiai, K., Kadosawa, T., Kimura, T. and Umemura, T. Canine hemangiopericyloma : an evaluation of metastatic potential. J. Vet. Diagn. Invest. 11:474-478, 1999.
  27. Ochiai, K., Kimura, T., Uematsu, K., Umemura, T., and Itakura, C. Lead poisoning in wild waterfowl in Japan. J. Wildl. Dis. 35:766-769, 1999.
  28. Mikami, O., Park, J. H., Kimura, T., Ochiai, K. and Itakura, C. Hepatic lesions in young rabbits experimentally infected with rabbit haemorrhagic disease virus. Res. Vet. Sci. 66:237-242, 1999.
  29. Mizutani, T., Ogino, M., Nishino, Y., Kimura, T., Inagaki, H., Hayasaka, D., Kariwa, H. and Takashima, I. Single-step reverse transcriptase-polymerase chain reaction for detection of Borna disease virus RNA in vitro and in vivo. Jpn. J. Vet. Res. 46:165-9, 1999.
  30. Ochiai, K., Ohashi, K., Mukai, T., Kimura, T., Umemura, T. and Itakura, C. Evidence of neoplastic nature and viral aetiology of so-called fowl glioma. Vet. Rec. 145:79-81, 1999.
  31. Hayashida, E., Ochiai, K., Kadosawa, T., Kimura, T. and Umemura, T. Arteriovenous malformation of the cervical spinal cord in a dog. J. Comp. Pathol. 121:71-76, 1999.
  32. Hirai, T., Mizutani, M., Kimura, T., Ochiai, K., Umemura, T. and Itakura, C. Neurotoxic effects of 2,5-Hexanedione on normal and neurofilament-deficient quail. Toxicol. Pathol. 27:348-353, 1999.
  33. Cho, K-O., Kimura, T., Ochiai, K. and Itakura, C. Gizzard adenocarcinoma in an aged Humboldt penguin (Spheniscus humboldti). Avian Pathol. 27:100-102, 1998.
  34. Okada, Y., Ochiai, K., Osaki, K., Kimura, T. and Itakura, C. Bronchiolar-alveolar carcinoma in a cow. J. Comp. Pathol. 118:69-74, 1998.
  35. Mizutani, T., Ogino, M, Nishino, Y., Kimura, T., Kariwa, H., Tsujimura, K., Inagaki, H. and Takashima, I. A single-tube RT-PCR method for the detection of Borna disease viral genomic RNA. Jpn. J. Vet. Res. 46:73-81, 1998.
  36. Cho K-O., Endoh, D., Kimura, T., Ochiai, K. and Itakura, C. Significance of Marek’s disease virus serotype 1-specific phosphorylated protein in Marek’s disease skin lesions. Avian Pathol. 26:707-720, 1997.
  37. Hirai, T., Mubarak, M., Kimura, T., Ochiai, K. and Itakura, C. Apocrine gland tumor of the eyelid in a dog. Vet. Pathol. 34:232-234, 1997.
  38. Cho, K-O. , Mubarak. M, Kimura, T., Ochiai, K. and Itakura, C. Sequential skin lesions in chickens experimentally infected with Marek’s disease virus. Avian Pathol. 25:325-343, 1996.
  39. Tanaka, S., Braga III, I. S., Kimura, T., Ochiai, K., Itakura, C. and Mizutani, M. Inherited Muscular Disorder in Mutant Japanese Quail (Coturnix coturnix japonica): an Immunohistochemical Study. J. Comp. Path. 115:139-150, 1996.
  40. Tanaka, S., Braga III, I. S., Kimura, T., Ochiai, K., Itakura, C., Mizutani, M. Inherited muscular disorder in mutant Japanese quail (Coturnix coturnix japonica): an ultrastructural study. J. Comp. Pathol. 114:325-337, 1996.
  41. Braga III, I. S., Tanaka, S., Kimura, T., Itakura, C., Mizutani, M. Inherited muscular disorder in mutant Japanese quail (Coturnix Coturnix japonica): Relationship between the development of muscle lesions and age. J. Comp. Pathol. 113:131-143, 1995.
  42. Kimura, T., Kimura-Kuroda, J., Nagashima, K., Yasui, K. Analysis of virus-cell binding characteristics on the determination of Japanese encephalitis virus susceptibility. Arch. Virol. 139:239-251, 1994.

原著論文(和文)

  1. 伊藤謙一、川嶋和晴、大庭芳和、播谷亮、木村享史、板倉智敏.静岡県における兎出血病の発生.日本獣医師会雑誌 50:523-526, 1997.
  2. 斎藤巨志、中川勇三、石原高文、木村享史、長嶋和郎.キスカル酸レセプター刺激によるイノシトールリン脂質代謝応答の加齢ラット海馬での増大.神経化学 29:472-473, 1990.
  3. 木村享史.日本脳炎ウイルス高感受性細胞および低感受性細胞におけるウイルス吸着、侵入の解析.北海道医誌 69:857-866, 1994.

総説(英文)

  1. Griffin, D. E., Ubol, S., Despres, P., Kimura, T., Byrnes, A. 2001. Role of antibodies in controlling alphavirus infection of neurons. Curr. Top. Microbiol. Immunol. 260:191-200.

総説(和文)

  1. 木村享史.In situ polymerase chain reaction (in situ PCR) 法.日本獣医病理学会会報特集号 2-5, 1997.